СОВРЕМЕННЫЕ ДОКАЗАТЕЛЬНЫЕ ДАННЫЕ ЭФФЕКТИВНОСТИ ПРИМЕНЕНИЯ LACTOBACILLUS RHAMNOSUS GG И BIFIDOBACTERIUM LACTIS ВB-12 В ПЕДИАТРИЧЕСКОЙ ПРАКТИКЕ
Аннотация
В настоящее время достаточно широко распространено профилактическое и терапевтическое применение пробиотиков при самых различных патологических состояниях, однако доказанной эффективностью они обладают лишь при некоторых заболеваниях. В данном обзоре представлены сведения об эффективности использования двух пробиотических микроорганизмов (L. rhamnosus GG и B. lactis Вb-12) в педиатрической практике. Суммированы имеющиеся на сегодняшний день доказательные данные относительно эффективности использования пробиотиков для лечения острой диареи, профилактики антибиотик-ассоциированной диареи и нозокомиальных инфекций, определено место L. rhamnosus GG и B. lactis Вb-12 в профилактике инфекций дыхательных путей и ЖКТ у детей, рассмотрено лечебное и профилактическое использование пробиотиков при аллергических заболеваниях и других нозологических формах. Отдельное внимание уделено вопросам безопасности пробиотиков.
Об авторе
И. В. Андреева
НИИ антимикробной химиотерапии Смоленской государственной медицинской академии
Россия
Россия
Контактная информация: Андреева Ирина Вениаминовна, старший научный сотрудник, доцент, кандидат медицинских наук Адрес: 214019, Смоленск, ул. Крупской, д. 28, а/я 5, тел.: (4812) 61-13-01, e-mail: Irina.Andreeva@antibiotic.ru
Список литературы
1. Reid G. Regulatory and clinical aspects of dairy probiotics. FAO/WHO Expert Consultation on Evaluation of Health and Nutritional Properties of Powder Milk with Live Lactic Acid Bacteria. — Cordoba, Argentina, 2001. — С. 1–34.
2. World Gastroenterology Organization practice guideline: Probiotics and prebiotics // Arab. J. Gastroenterology. — 2009; 10 (1): 33–42.
3. Holzapfel W. H., Haberer P., Geisen R. et al. Taxonomy and important features of probiotic microorganisms in food and nutrition // Am. J. Clin. Nutr. — 2001; 73 (2): 365–73.
4. Salminen S., Benno Y., de Vos W. Intestinal colonisation, microbiota and future probiotics? // Asia Pac. J. Clin. Nutr. — 2006; 15 (4): 558–62.
5. Van der Waaij D. Colonization resistance of the digestive tract — mechanism and clinical consequences // Nahrung. — 1987; 31 (5–6): 507–17.
6. Silva M., Jacobus N. V., Deneke C. et al. Antimicrobial substance from a human Lactobacillus strain // Antimicrob. Agents. Chemother. — 1987; 31 (8): 1231–3.
7. Gorbach S. L., Goldin B. R. Lactobacillus strains and methods of selection // US Patent. N 4839281.
8. Conway P. L., Gorbach S. L., Goldin B. R. Survival of lactic acid bacteria in the human stomach and adhesion to intestinal cells // J. Dairy. Sci. — 1987; 70 (1): 1–12.
9. Reid G., Jass J., Sebulski M. T. et al. Potential uses of probiotics in clinical practice // Clin. Microbiol. Rev. — 2003; 16 (4): 658–72.
10. Guandalini S., Pensabene L., Zikri M. A. et al. Lactobacillus GG administered in oral rehydration solution to children with acute diarrhea: a multicenter European trial // J. Pediatr. Gastroenterol. Nutr. — 2000; 30: 54–60.
11. Shornikova A. V., Isolauri E., Burkanova L. et al. A trial in the Karelian Republic of oral rehydration and Lactobacillus GG for treatment of acute diarrhea // Acta. Paediatr. — 1997; 86 (5): 460–5.
12. Raza S., Graham S. M., Allen S. J. et al. Lactobacillus GG promotes recovery from acute nonbloody diarrhea in Pakistan // Pediatr. Infect. Dis. J. — 1995; 14 (2): 107–11.
13. Huang J., Bousvaros A., Lee J. et al. Efficacy of probiotic use in acute diarrhea in children, a meta-analysis // Dig. Dis. Sci. — 2002; 47 (11): 2625–34.
14. Van Niel C. W., Feudtner C., Garrison M. M. et al. Lactobacillus therapy for acute infectious diarrhea in children: a metaanalysis // Pediatrics. — 2002; 109 (4): 678–84.
15. Saavedra J. M., Abi-Hanna A., Moore N. et al. Long-term consumption of infant formulas containing live probiotic bacteria: tolerance and safety // Am. J. Clin. Nutr. — 2004; 79 (2): 261–7.
16. Szajewska H., Kotowska M., Mrukowicz J. Z. et al. Efficacy of Lactobacillus GG in prevention of nosocomial diarrhea in infants // J. Pediatr. — 2001; 138 (3): 361–5.
17. Hojsak I., Abdovic S., Szajewska H. et al. Lactobacillus GG in the prevention of nosocomial gastrointestinal and respiratory tract infections // Pediatrics. — 2010; 125 (5): е1171–7.
18. McFarland L. V. Diarrhea acquired in the hospital // Gastroenterol. Clin. North. Am. 1993; 22: 563–77.
19. Plummer S., Weawer M., Dee P. et al. Clostridium difficile pilot study: effects of probiotic supplementation on the incidence of C. difficile diarrhea // Int. Мicrobiоl. — 2004; 7 (1): 59–62.
20. D'Souza A. L., Rajkumar C., Cooke J. et al. Probiotics in prevention of antibiotic associated diarrhoea: meta-analysis // BMJ. — 2002; 324 (7350): 1361.
21. Arvola T., Laiho K., Torkkeli S. et al. Prophylactic Lactobacillus GG reduces antibiotic-associated diarrhea in children with respiratory infections: a randomized study // Pediatrics. — 1999; 104 (5): e64.
22. Vanderhoof J. A., Whitney D. B., Antonson D. L. et al. Lactobacillus GG in the prevention of antibiotic-associated diarrhea in children // J. Pediatr. — 1999; 135 (5): 564–8.
23. Johnston B. C., Supina A. L., Vohra S. Probiotics for pediatric antibiotic-associated diarrhea: a meta-analysis of randomized placebo-controlled trials // CMAJ. — 2006; 175 (4): 377–83.
24. Szajewska H., Ruszczynski M., Radzikowski A. Probiotics in the prevention of antibiotic-associated diarrhea in children: a metaanalysis of randomized controlled trials // J. Pediatr. — 2006; 149 (3): 367–72.
25. Johnston B. C., Supina A. L., Ospina M. et al. Probiotics for the prevention of pediatric antibiotic-associated diarrhea // Cochrane Database Syst. Rev. — 2007; (2): CD004827.
26. Isolauri E. Dietary modification of atopic disease: Use of probiotics in the prevention of atopic dermatitis // Curr. Allergy. Asthma. Rep. — 2004; 4 (4): 270–5.
27. Schmidt W. P. Model of the epidemic of childhood atopy // Med. Sci. Monit. — 2004; 10 (2): HY5.
28. Kalliomaki M., Isolauri E. Role of intestinal flora in the development of allergy // Curr. Opin. Allergy. Clin. Immunol. — 2003; 3 (1): 15–20.
29. Rosenfeldt V., Benfeldt E., Valerius N. H. et al. Effect of probiotics on gastrointestinal symptoms and small intestinal permeability in children with atopic dermatitis // J. Pediatr. — 2004; 145 (5): 612–6.
30. Majamaa H., Isolauri E. Probiotics: a novel approach in the management of food allergy // J. Allergy. Clin. Immunol. — 1997; 99 (2): 179–85.
31. Research suggests potential role for probiotics in treating allergy // Infect. Dis. Childr. — 2003; 3: 72.
32. Kalliomaki M., Salminen S., Poussa T. et al. Probiotics and prevention of atopic disease: 4-year follow-up of a randomised placebo-controlled trial // Lancet. — 2003; 361 (9372): 1869–71.
33. Rautava S., Kalliomaki M., Isolauri E. Probiotics during pregnancy and breast-feeding might confer immnomodulatory protection against atopic disease in the infant // J. Allergy. Clin. Immunol. — 2002; 109 (1): 119–21.
34. Hanifin J. M., Cooper K. D., Ho V. C. et al. Guidelines of care for atopic dermatitis, developed in accordance with the American Academy of Dermatology (AAD) / American Academy of Dermatology Association «Administrative Regulations for Evidence-Based Clinical Practice Guidelines» // J. Am. Acad. Dermatol. — 2004; 50 (3): 391–404.
35. Isolauri E., Arvola T., Sutas Y. et al. Probiotics in the management of atopic eczema // Clin. Exp. Allergy. — 2000; 30 (11): 1604–10.
36. Viljanen M., Savilahti E., Haahtela T. et al. Probiotics in the treatment of atopic eczema/dermatitis syndrome in infants: a double-blind placebo-controlled trial // Allergy. — 2005; 60 (4): 494–500.
37. Collet J. P., Burtin P., Gillet J. еt аl. Risk of infectious diseases in children attending different types of day-care setting // Respiration 1994; 61 (Suppl. 1): 16–9.
38. Nafstad P., Hagen J. A., Oie L. et al. Day care centers and respiratory health // Pediatrics. — 1999; 103: 753–8.
39. Hatakka K., Savilahti E., Ponka A. et al. Effect of long term consumption of probiotic milk on infections in children attending day care centres: double blind, randomised trial // BMJ. — 2001; 322 (7298): 1327.
40. Hojsak I., Snovak N., Abdovic S. et al. Lactobacillus GG in the prevention of gastrointestinal and respiratory tract infections in children who attend day care centers: a randomized, double-blind, placebo-controlled trial // Clin. Nutr. — 2010; 29 (3): 312–6.
41. Rautava S., Arvilommi H., Isolauri E. Specific probiotics in enhancing maturation of IgA responses in formula-fed infants // Pediatr. Res. — 2006; 60 (2): 221–4.
42. Rautava S., Salminen S., Isolauri E. Specific probiotics in reducing the risk of acute infections in infancy — a randomised, double-blind, placebo-controlled study // Br. J. Nutr. — 2009; 101 (11): 1722–6.
43. Taipale T., Pienihakkinen K., Isolauri E. et al. Bifidobacterium animalis subsp. lactis Bb-12 in reducing the risk of infections in infancy // Br. J. Nutr. — 2010; 24: 1–7.
44. Loesche W. J. Microbiology of dental decay and periodontal disease. In: Baron’s Medical Microbiology (4th Ed). — University of Texas Medical Branch, 1996.
45. Nase L., Hatakka K., Savilahti E. et al. Effect of long-term consumption of a probiotic bacterium, Lactobacillus rhamnosus GG, in milk on dental caries and caries risk in children // Caries. Res. — 2001; 35 (6): 412–20.
46. Guidelines for the Evaluation of Probiotics in Food. Joint FAO/WHO (Food and Agriculture Organization/World Health Organisation)/Working Group. London, Ontario, Canada, 2002.
47. Mackay A. D., Taylor M. B., Kibbler C. C. et al. Lactobacillus endocarditis caused by a probiotic organism // Clin. Microbiol. Infect. — 1999; 5: 290–2.
48. Rautio M., Jousimies-Somer H., Kauma H. et al. Liver abscess due to a Lactobacillus rhamnosus strain indistinguishable from L. rhamnosus strain GG // Clin. Infect. Dis. — 1999; 28: 1159–60.
49. Salminen M. K., Rautelin H., Tynkkynen S. et al. Lactobacillus bacteremia, clinical significance, and patient outcome, with special focus on probiotic L. rhamnosus GG // Clin. Infect. Dis. — 2004; 38 (1): 62–9.
50. Land M. H., Rouster-Stevens K., Woods C. R. et al. Lactobacillus sepsis associated with probiotic therapy // Pediatrics. — 2005; 115 (1): 178–81.
51. De Groote M. A., Frank D. N., Dowell E. et al. Lactobacillus rhamnosus GG bacteremia associated with probiotic use in a child with short gut syndrome // Pediatr. Infect. Dis. J. — 2005; 24 (3): 278–80.
52. Robin F., Paillard C., Marchandin H. et al. Lactobacillus rhamnosus meningitis following recurrent episodes of bacteremia in a child undergoing allogeneic hematopoietic stem cell transplantation // J. Clin. Microbiol. — 2010; 48 (11): 4317–9.
53. Luong M. L., Sareyyupoglu B., Nguyen M. H. et al. Lactobacillus probiotic use in cardiothoracic transplant recipients: a link to invasive Lactobacillus infection? // Transpl. Infect. Dis. — 2010; 12 (6): 561–4.
54. Salminen M. K., Tynkkynen S., Rautelin H. et al. Lactobacillus bacteremia during a rapid increase in probiotic use of Lactobacillus rhamnosus GG in Finland // Clin. Infect. Dis. — 2002; 35 (10): 1155–60.
Рецензия
Для цитирования:
Андреева И.В. СОВРЕМЕННЫЕ ДОКАЗАТЕЛЬНЫЕ ДАННЫЕ ЭФФЕКТИВНОСТИ ПРИМЕНЕНИЯ LACTOBACILLUS RHAMNOSUS GG И BIFIDOBACTERIUM LACTIS ВB-12 В ПЕДИАТРИЧЕСКОЙ ПРАКТИКЕ. Вопросы современной педиатрии. 2011;10(1):50-57.
For citation:
Andreyeva I.V. EVIDENCE-BASED DATA ON EFFECTIVENESS OF LACTOBACILLUS RHAMNOSUS GG AND BIFIDOBACTERIUM LACTIS ВB-12 IN PEDIATRIC PRACTICE. Current Pediatrics. 2011;10(1):50-57. (In Russ.)
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