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EFFICACY OF INFLIXIMAB IN PATIENT WITH UNFAVORABLE CLINICAL COURSE OF JUVENILE RHEUMATOID ARTHRITIS

Abstract

The article presents a case report of aggressive rapidly progressive severe polyarticular juvenile rheumatoid arthritis (JRA) resistant to standard immunosuppressive treatment. Patient with extra-early (up to 6 months) arthritis was successfully treated with genetically engineered biological agent infliximab. Pain decreased significantly after first injection of a drug, the second injection resulted in decrease of laboratory activity, third one completely stopped exudative lesion of joints, morning stiffness, and restored functional activity of a child. Thus, after 6 months the disease was transferred to inactive phase, motions of joints restored, there was no need in nonsteroid anti-inflammatory drugs. Cardiovascular symptoms stopped as well. The case report showed high efficacy of tumor necrotizing factor _ blocker infliximab in patients with aggressive clinical course and markers of unfavorable prognosis at very early stages of JRA before irreversible lesions of joints happen.
Key words: children, early juvenile rheumatoid arthritis, infliximab, treatment.
(Voprosy sovremennoi pediatrii — Current Pediatrics. 2011; 10 (3): 157–165)

About the Authors

L.A. Balykova
N.P. Ogaryov Mordovia State University, Saransk


N.V. Ivyanskaya
Mordovia Children’s Republic Clinical Hospital № 2, Saransk


T.I. Kornilova
Mordovia Children’s Republic Clinical Hospital № 2, Saransk


A.V. Balykova
N.P. Ogaryov Mordovia State University, Saransk


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Review

For citations:


Balykova L., Ivyanskaya N., Kornilova T., Balykova A. EFFICACY OF INFLIXIMAB IN PATIENT WITH UNFAVORABLE CLINICAL COURSE OF JUVENILE RHEUMATOID ARTHRITIS. Current Pediatrics. 2011;10(3):157–165.

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