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CELIAC DISEASE IN CHILDREN: SOLVED AND UNSOLVED QUESTIONS OF AETIOPATHOGENESIS

Abstract

In the recent decade, thanks to rapid development of new immunologic, morphologic and biologic methods we have achieved dramatic progress in understanding of celiac disease aetiopathogenesis. The whole image of the disease has been changed and enlarged — now it’s defined as an immunemediated multisystemic disease, that is caused by gluten and corresponding prolamines among genetically vulnerable individuals, that is characterized by a variety of gluten-dependant clinical features, specific antibodies, HLA DQ2 and DQ8 haplotypes and enteropathy. According to this novel approach, we regard possibilities of celiac disease diagnostic algorithm improvement, especially among patients from risk groups.
Key words: celiac disease, autoimmune disease, enteropathy, gluten, gliadine peptides, tissue transglutaminase, haplotypes HLA DQ2, DQ8.
(Voprosy sovremennoi pediatrii — Current Pediatrics. 2011; 10 (4): 30–35)

About the Authors

I.N. Zakharova
Russian medical academy of postgraduate education, Moscow


Т.E. Borovik
Scientific Center of Children’s Health, Russian Academy of Medical Sciences, Moscow


Е.А. Roslavtseva
Scientific Center of Children’s Health, Russian Academy of Medical Sciences, Moscow


Е.N. Andrukhina
Russian medical academy of postgraduate education, Moscow


Yu.А. Dmitrieva
Russian medical academy of postgraduate education, Moscow


F.S. Dzebisova
Russian medical academy of postgraduate education, Moscow


References

1. Dowd B., Walker-Smith J., Gee S. Arateus and the coeliac affection. Brit. Med. J. 1974; 2: 445–447.

2. Cluysenaer O.J.J., van Tongeren J.H.M. Malabsorptionin coeliac sprue. The Hague. Martinus Nijhoff Medical Division. 1977. Р. 1–4.

3. Gee S. On the coeliac affection. St. Bartholomew’s Hospital Report. 1888; 24: 17–20.

4. Di Sant–Agnese P.A., Darling R., Perera G., Shea E. Abnormal electrolyte composition of sweat in cystic fibrosis of the pancreas. Pediatrics. 1953; 12: 549–551.

5. Dicke W.K. Coeliakie. Een onderzoek naar de nadelige invloed van sommige graansoorten op de lijder aan coeliakie. MD Thesis. Utrecht. 1950.

6. Paulley J.W. Observations on the aetiology of idiopathic steatorrhoea. Jejunal and lymph-node biopsies. Br. Med. J. 1954; 4: 1318–1321.

7. Dieterich W., Ehnis T., Bauer M. et al. Identification of tissue transglutaminase as the autoantigen of celiac disease. Nat. Med. 1997; 3: 725–726.

8. Shan L., Molberg O., Parrot I. et al. Structural basis for gluten intolerance in celiac sprue. Science. 2002; 297: 2275–2279.

9. Dubé C., Rostom A., Sy R. еt al. The prevalence of celiac disease in average risk and at risk Western European populations: a systematic review. Gastroenterology. 2005; 128: 57–67.

10. Greco L., Romino R., Coto I. et al. The first large population based twin study of coeliac disease. Gut. 2002; 50: 624–628.

11. Nistico L., Fagnani C., Coto I. et al. Concordance, disease progression, and heritability of coeliac disease in Italian twins. Gut. 2006; 55: 803–808.

12. Tollefsen S., Arentz-Hansen H., Fleckenstein B. et al. HLA-DQ2 and -DQ8 signatures of gluten T cell epitopes in celiac disease. J. Clin. Invest. 2006; 116 (8): 2226–2236.

13. Sollid L.M. Molecular basis of celiac disease. Ann Rev. Immunol. 2000; 18: 53–81.

14. Karell K., Louka A.S., Moodie S.J. et al. HLA types in celiac disease patients not carrying the DQA1*05-DQB1*02 (DQ2) heterodimer: results from the European Genetics Cluster on Celiac Disease. Hum. Immunol. 2003; 64: 469–477.

15. Korponay–Szabo I.R. Pathogenesis of coeliac disease. Materials of CD–Medics Training Seminar «Coeliac disease a holistic approach». 2009; 10: 8–10.

16. Wolters V.M., Wijmenga C. Genetic Background of Celiac Disease and Its Clinical Implications. Am. J. Gastroenterol. 2008; 103 (1): 190–195.

17. Пухликова Т.В., Лебедева Л.Л., Потапова Т.Н. и др. Значение генетических факторов в развитии целиакии. Вопросы современной педиатрии. 2010; 9 (4): 40–43.

18. Кондратьева Е.И., Пузырев В.П., Рудко А.А. и др. Поиск ассоциации полиморфных вариантов генов–модификаторов с целиакией у детей и подростков Томской области. Сибирский вестник гепатологии и гастроэнтерологии. 2006; 20: 68–72.

19. Petronzelli F., Bonamico M., Ferrante P. et al. Genetic contribution of the HLA region to the familial clustering of coeliac disease. Ann Hum. Genet. 1997; 61: 307–317.

20. Catassi C., Fasano A. Celiac disease. Curr. Оpin. Gastroenterol. 2008; 24: 687–691.

21. Holopainen P., Mustalahti K., Uimari P. et al. Candidate gene regions and genetic heterogeneity in gluten sensitivity. Gut. 2001; 48: 696–701.

22. Evaluation of cytokine polymorphisms (TNFalpha, IFNgamma and IL–10) in Down patients with coeliac disease. Dig. Liver Dis. 2005; 37 (12): 923–927.

23. Ivarsson A., Persson L.A., Nystrom L. et al. Epidemic of coeliac disease in Swedish children. Acta Paediatr. 2000; 89 (2): 165–171.

24. Ivarsson A., Hernell O., Stenlund H., Persson L.A. Breast-feeding protects against celiac disease. Am. J. Clin. Nutr. 2002; 75 (5): 914–921.

25. Sandberg–Bennich S., Dahlquist G., Kallen B. Coeliac disease is associated with intrauterine growth and neonatal infections. Acta Paediatr. 2002; 91 (1): 30–33.

26. Stene L.C., Honeyman M.C., Hoffenberg E.J. et al. Rotavirus infection frequency and risk of celiac disease autoimmunity in early childhood: a longitudinal study. Am. J. Gastroenterol. 2006; 101 (10): 2333–2340.

27. Plot L., Amital H. Infectious associations of celiac disease. Autoimmun. Rev. 2009; 8 (4): 316–319.

28. Sandstrom O. Multifactorial etiology of celiac disease. Materials of CD–Medics Training Seminar «Coeliac disease a holistic approach». 2009. Р. 11–13.

29. Forsberg G., Fahlgren A., Horstedt P. et al. Presence of bacteria and innate immunity of intestinal epithelium in childhood celiac disease. Am. J. Gastroenterol. 2004; 99: 894–904.

30. Nadal I., Donant E., Ribes-Koninckx C. et al. Imbalance in the composition of the duodenal microbiota of children with coeliac disease. J. Med. Microbiol. 2007; 56: 1669–1674.

31. Sollid L.M. Coeliac disease: dissecting a complex inflammatory disorder. Nat. Rev. Immunol. 2002; 2: 647–655.

32. Бельмер С.В., Гасилина Т.В. Возможные и невозможные механизмы повреждения слизистой оболочки тонкой кишки при целиакии. В кн.: Целиакия у детей. Под ред. С.В. Бельмер, М.О. Ревнова. М.: Медпрактика–М. 2010. С. 58–89.

33. Van de Wal Y., Kooy Y., van Veelen P. et al. Selective deamidation by tissue transglutaminase strongly enhances gliadin specific T cell reactivity. J. Immunol. 1998; 161: 1585–1588.

34. Arentz–Hansen H., Korner R., Molberg O. et al. The intestinal T cell response to alpha-gliadin in adult celiac disease is focused on a single deamidated glutamine targeted by tissue transglutaminase. J. Exp. Med. 2000; 191: 603–612.

35. Alaedini A., Green P. Narrative Review: Celiac Disease: Understanding a Complex Autoimmune Disorder. Ann. Intern. Med. 2005; 142: 289–298.

36. Marsh M.N. Mucosal pathology in gluten sensitivity. In: Coeliac Disease. Ed. M.N. Marsh. Oxford: Blackwell Scientific Publications. 1992. Р. 136–191.

37. Jabri B., de Serre N.P., Cellier C. et al. Selective expansion of intraepithelial lymphocytes expressing the HLA–E specific natural killer receptor CD94 in celiac disease. Gastroenterol. 2000; 118: 867–879.

38. Hьe S., Mention J.J., Monteiro R.C. et al. A direct role for NKG2D/MICA interaction in villous atrophy during celiac disease. Immunity. 2004; 21: 367–377.

39. Meresse B., Chen Z., Ciszewski C. et al. Coordinated induction by IL15 of a TCR independent NKG2D signaling pathway converts CTL into lymphokine activated killer cells in celiac disease. Immunity. 2004; 21: 357–366.

40. Sollid L.M., Jabri B. Is celiac disease an autoimmune disorder? Curr. Opin. Immunol. 2005; 17: 595–600.

41. Maiuri L., Ciacci C., Ricciardelli I. et al. Association between innate response to gliadin and activation of pathogenic T cells in coeliac disease. Lancet. 2003; 362: 30–37.

42. Dickey W., Hughes D.F., McMillan S.A. Patients with serum IgA endomysial antibodies and intact duodenal villi: clinical characteristics and management options. Scand. J. Gastroenterol. 2005; 40: 1240–1243.

43. Hill I.D., Dirks M.H., Liptak G.S. et al. Guideline for the diagnosis and treatment of celiac disease in children: recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition. J. Pediatr. Gastroenterol. Nutr. 2005; 40: 1–19.


Review

For citations:


Zakharova I., Borovik Т., Roslavtseva Е., Andrukhina Е., Dmitrieva Yu., Dzebisova F. CELIAC DISEASE IN CHILDREN: SOLVED AND UNSOLVED QUESTIONS OF AETIOPATHOGENESIS. Current Pediatrics. 2011;10(4):30–35.

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