Preview

Current Pediatrics

Advanced search

IMMUNITY DYSFUNCTION IN RESPIRATORY DISEASES: DO FREQUENTLY ILL CHILDREN NEED IMMUNOMODULATORS?

https://doi.org/10.15690/vsp.v14i2.1295

Abstract

Insufficient control of many infectious diseases using etiotropic drugs determines the relevance of a search for alternative methods, in particular based on the modulation of the immune system. The review of recent literature analyzes rational approaches to the immunity dysfunction in frequently ill children. Attention is drawn to the fact that the use of immunomodulators reduces the frequency and severity of respiratory diseases and prevents complications. The article examines the advantages of the use of inosine pranobex that combines the properties of an immunomodulator and a direct antiviral activity. It is shown that inosine pranobex can be used for the prevention and treatment of respiratory infections in frequently ill children, and the rational schemes of its application are presented.

 

About the Author

A. V. Karaulov
I.M. Sechenov First Moscow State Medical University, Russian Federation
Russian Federation
 


References

1. Karaulov A.V., Kalyuzhin O.V. Immunotherapy of Infectious Diseases: Challenges and Prospects. Terapevticheskii arkhiv = Therapeutic archive. 2013; 11: 100–108.

2. Treating infectious diseases in a microbial world: Report of two workshops on novel antimicrobial therapeutics. Washington: National Academies Press. 2006. P. 37–38.

3. Namazova-Baranova L.S., Kharit S.M., Tuzankina I.A., Kozhevnikova T.I., Taranushenko T.E., Alekseeva A.A. The results of a multicenter study of the drug pidotimod for the prevention of acute respiratory infections in RRI children. Voprosy sovremennoi pediatrii = Current pediatrics. 2010; 2: 40–44.

4. Karaulov A.V., Pinegin B.V., Il'ina N.I. et al. Polioksidonii v klinicheskoi praktike. Terapiya, khirurgiya, ginekologiya, urologiya, onkologiya. Pod red. A.V. Karaulova [Polyoxidonium in Clinical Practice. Medicine, Surgery, Gynecology, Urology, Oncology. Edited by A.V. Karaulov]. Moscow, GEOTAR-Media, 2008. 135 p.

5. Feleszko W., Marek Ruszczynski, Bartlomiej Mateusz Zalewski Non-specific immune stimulation in respiratory tract infections. Separating the wheat from the chaff. Paediatr. Respir. Rev. 2014; 15: 200–206.

6. Labro M.-T. Immunomodulation and infection: back to the future. Exp. Rev. Anti-Infect. Ther. 2012; 10 (3): 245–247.

7. Karaulov A.V., Sokurenko S.I., Barmotin V.G. Principles of immunotherapy and immunorehabilitation recurrent respiratory diseases. Lechashchii vrach = Practicing doctor. 2000; 1: 44–45.

8. Markova T.P. Primenenie immunotropnykh preparatov v kompleksnom lechenii i vaktsinatsii detei s immunodefitsitnymi sostoyaniyami. Avtoref. dis. … dokt. med. nauk [Application of immune preparations in complex treatment and vaccination of children with immunodeficiency. Author’s abstract]. Moscow, 2011. 48 p.

9. Vishneva E.A., Namazova-Baranova L.S. Prevention of allergies in children. Pediatricheskaya farmakologiya = Pediatric pharmacology. 2014; 11 (3): 61–65.

10. Ershov F.I. Antivirusnye preparaty [Antiviral drugs]. Moscow, Meditsina. 1998. 192 p.

11. Golebiowska-Wawrzyniak M., Markiewicz K., Kozar A., Derentowicz P., Czerwi ska-Kartowicz I., Jastrzebska-Janas K., Wacawek J., Wawrzyniak Z.M., Siwiska-Goleblowska H. Immunological and clinical study on therapeutic efficacy of inosine pranobex. Pol. Merkur Lek. 2005; 19 (111): 379–382.

12. Sergienko E.N., Shmeleva N.P., Germanenko I.G., Gribkova N.V. Flu in children: clinical and epidemiological features and new possibilities of therapy. Meditsinskie novosti = Medical news. 2009; 14: 1–4.

13. Ohnishi H., Kosuzume H., Inaba H., Okura M., Tajima H., Suzuki Y. Protective effects of inosiplex in viral infections. Comparison with other immunostimulants. Kansenshogaku Zasshi. 1981; 55 (8): 551–557.

14. Indeks ATC, 2009. Klassifikator sistemy ATS/DDD (The index of ATC, 2009. Qualifier PBX system / DDD). Available at: http://www.whocc.no/atcddd (accessed: 06.03.2015).

15. Darlath W., Wybran J. Therapeutic experience with the immunostimulator inosine pranobex. Fortschr. Med. 1984; 4; 102 (37): 932–934.

16. Belyaeva L.M. Groprinosin in treatment of RRI children and adolescents. Meditsinskie novosti = Medical news. 2007; 8: 43–45.

17. Isakov V.A., Isakov D.V. Prospects for treatment of respiratory infections in frequently ill patients. Pul'monologiya = Pulmonology. 2014; 4: 118–124.

18. Osidak L.V., Zarubaev V.V., Obraztsova E.V., Erman E.S., Drinevskii V.P. Izoprinozin in the treatment of ARI in RRI children. Detskie infektsii = Child infections. 2008; 4: 35–41.

19. Eliseeva M.Yu., Tsarev V.N., Masikhi K.N., Osidak L.V., Barinskii I.F., Tsareva T.V., Mynbaev O.A. The effectiveness of the auxiliary immunotherapy in patients with immunodeficiency and sickly children: a systematic review and meta-analysis of the use of inosine pranobex with SARS. RMZh = Russian medical journal. 2010; 18 (5:369): 313–320.

20. Bulgakova V.A., Balabolkin I.I., Katosova L.K., Sedova M.O., Zubkova I.V. Evaluating the effectiveness of the combined effect of immunomodulator inosine pranobex for the prevention of respiratory infections in children with allergies. Pediatricheskaya farmakologiya = Pediatric pharmacology. 2010; 7 (5): 30–37.

21. Litzman J., Lokaj J., Krejci M., Pesak S., Morgan G. Isoprinosine does not protect against frequent respiratory tract infections in childhood. Eur. J. Pediatr. 1999; 158: 35–37.

22. Schneider D.S., Ayres J.S. Two ways to survive infection: what resistance and tolerance can teach us about treating infectious diseases. Nat. Rev. Immunol. 2008; 8 (11): 889–895.

23. Casadevall A., Pirofski L.-A. The damage-response framework of microbial pathogenesis. Nat. Rev. Microbiol. 2003; 1: 17–24.


Review

For citations:


Karaulov A.V. IMMUNITY DYSFUNCTION IN RESPIRATORY DISEASES: DO FREQUENTLY ILL CHILDREN NEED IMMUNOMODULATORS? Current Pediatrics. 2015;14(2):260-264. (In Russ.) https://doi.org/10.15690/vsp.v14i2.1295

Views: 1102


ISSN 1682-5527 (Print)
ISSN 1682-5535 (Online)