RESULTS OF RETROSPECTIVE OBSERVATIONAL STUDY OF ADALIMUMAB SAFETY AND EFFICACY IN PATIENTS WITH JUVENILE ARTHRITIS AND UVEITIS
Abstract
The article contains results of retrospective observational study of adalimumab safety and efficacy in 67 juvenile arthritis and juvenile arthritis with eye involvement patients refractory to classical immunosuppressive treatment. It also contains a description of a recombinant biological medication — adalimumab: already on the 4th week of treatment acute inflammatory changes in the affected joints were relieved, joint motion range fully recovered; by the week 8 — full remission of the uveitis was reported in 45% of affected eyes (27/61), normalized disease activity lab parameters such as ESR, serum C-reactive protein.
Key words: children, juvenile rheumatoid arthritis, rheumatoid uveitis, adalimumab.
(Voprosy sovremennoi pediatrii — Current Pediatrics. — 2011; 10 (6): 96–102)
About the Authors
Е.I. AlexeevaRussian Federation
Е.V. Mitenko
Russian Federation
Т.М. Bzarova
Russian Federation
S.I. Valieva
Russian Federation
А.М. Chomakhidze
Russian Federation
K.B. Isaeva
Russian Federation
Е.G. Chistyakova
Russian Federation
R.V. Denisova
Russian Federation
T.V. Sleptsova
Russian Federation
Т.Yu. Polyaeva
Russian Federation
А.N. Fetisova
Russian Federation
Review
For citations:
Alexeeva Е., Mitenko Е., Bzarova Т., Valieva S., Chomakhidze А., Isaeva K., Chistyakova Е., Denisova R., Sleptsova T., Polyaeva Т., Fetisova А. RESULTS OF RETROSPECTIVE OBSERVATIONAL STUDY OF ADALIMUMAB SAFETY AND EFFICACY IN PATIENTS WITH JUVENILE ARTHRITIS AND UVEITIS. Current Pediatrics. 2011;10(6):96–102.
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