ПРИМЕНЕНИЕ БУДЕСОНИДА У ДЕТЕЙ ДОШКОЛЬНОГО ВОЗРАСТА
Аннотация
Бронхиальная астма остается широко распространенным заболеванием среди детей как младшего, так и старшего возраста. Ингаляционные кортикостероиды являются препаратами первой линии в терапии бронхиальной астмы у детей всех возрастов. В статье освещен вопрос применения будесонида (Пульмикорт) у дошкольников. Приведены данные различных исследований, подтверждающих эффективность и безопасность использования как турбухалера, так и небулированной формы препарата.
Ключевые слова: дети, бронхиальная астма, ингаляционные кортикостероиды, будесонид.
(Вопросы современной педиатрии. 2010;9(1):76-80)
Об авторах
Е.А. ВишневаРоссия
Л.С. Намазова-Баранова
Россия
Р.М. Торшхоева
Россия
Ю.Г. Левина
Россия
А.А. Алексеева
Россия
К.Е. Эфендиева
Россия
Список литературы
1. Аллергология и иммунология. Под общей ред. А.А. Баранова, Р.М. Хаитова. М.: М–студио. 2008. 240 с.
2. Asthma prevalence, health care use and mortality. National Center for Health Statistics, 2008. URL: http://www.cdc.gov/nchs/fastats/asthma.htm.
3. Emerman C.L., Cydulka R.K., Crain E.F. et al. Prospective multicenter study of relapse after treatment for acute asthma among children presenting to the emergency department. J. Pediatr. 2001; 138: 318–324.
4. Stevens M.W., Gorelick M.H. Short term outcomes after acute treatment of pediatric asthma. Pediatrics. 2001; 107: 1357–1362.
5. Bloomberg G.R., Trinkaus K.M., Fisher E.B. Jr. et al. Hospital readmissions for childhood asthma: a 10-year metropolitan study. Am. J. Respir. Crit. Care Med. 2003; 167: 1068–1076.
6. Mitchell E.A., Bland J.M., Thompson J.M. Risk factors for readmission to hospital for asthma in childhood. Thorax. 1994; 49: 33–36.
7. Schaubel D., Johansen H., Mao Y. et al. Risk of preschool asthma: incidence, hospitalization, recurrence, and readmission probability. J. Asthma. 1996; 33: 97–103.
8. Weiss K.B., Gergen P.J., Hodgson T.A. An economic evaluation of asthma in the United States. N. Engl. J. Med. 1992; 326: 862–866.
9. National Asthma Education and Prevention Program. Expert Panel Report: guidelines for the diagnosis and management of asthma update on selected topics – 2002. J. Allergy Clin. Immunol. 2002; 110: 141–219.
10. Donahue J.G., Weiss S.T., Livingston J.M. et al. Inhaled steroids and the risk of hospitalization for asthma. JAMA. 1997; 277: 887–891.
11. Sin D.D., Man S.F. Low dose inhaled corticosteroid therapy and risk of emergency department visits for asthma. Arch. Intern. Med. 2002; 162: 1591–1595.
12. Stempel D.A., Pinto L., Stanford R.H. The risk of hospitalization in patients with asthma switched from an inhaled corticosteroid to a leukotriene receptor antagonist. J. Allergy Clin. Immunol. 2002; 110: 39–41.
13. Suissa S., Ernst P. Inhaled corticosteroids: impact on asthma morbidity and mortality. J. Allergy Clin. Immunol. 2001; 107: 937–944.
14. Kofman C., Berlinski A., Zaragoza S. et al. Aerosol therapy for pediatric outpatients. J. Resp. Care Pract. 2004. URL: http://www.rtmagazine. com/issues/articles/2004-03_05.asp.
15. McLaughlin T., Leibman C. Risk of recurrent emergency department visits or hospitalizations in children with asthma receiving nebulized budesonide inhalation suspension compared with other asthma medications. Curr. Med. Res. Opin. 2007; 23 (6): 1319–1328.
16. Baker J.W., Mellon M., Wald J. et al. A multiple dosing, placebo controlled study of budesonide inhalation suspension given once or twice daily for treatment of persistent asthma in young children and infants. Pediatrics.1999; 103 (2): 414–421.
17. Shapiro G., Mendelson L., Kraemer M.J. et al. Efficacy and safety of budesonide inhalation suspension (Pulmicort Respules) in young children with inhaled steroid dependent, persistent asthma. J. Allergy Clin. Immunol. 1998; 102: 789–796.
18. Szefler S., Pedersen S. Role of budesonide as maintenance therapy for children with asthma. Pediatric. Pulm. 2003; 36 (1): 13–21.
19. Berger W.E., Shapiro G.G. The use of inhaled corticosteroids for persistent asthma in infants and young children. Ann. Allergy Asthma Immunol. 2004; 92: 387–400.
20. Jonasson G., Carlsen K.H., Mowinckel P. Asthma drug adherence in a long term clinical trial. Arch. Dis. Child. 2000; 83: 330–333.
21. Turpeinen M., the HEICA Study Group. Helsinki Early Intervention Childhood Asthma (HEICA) study: Inhaled budesonide halved the number of asthma exacerbations compared with inhaled disodium cromoglycate during 18 months of treatment. Eur. Respir. J. 2000; 16: 311.
22. Storm Van's Gravesande K., Mattes J., Endlicher A. et al. Effect of two doses of budesonide on exhaled nitric oxide and urinary EPX excretion in asthmatic children. Pneumologie. 2004; 58 (7): 483–488.
23. Shapiro G.G., Mendelson L.M., Pearlman D.S. Once-daily budesonide inhalation powder (Pulmicort Turbuhaler) maintains pulmonary function and symptoms of asthmatic children previously receiving inhaled corticosteroids. Ann. Allergy Asthma Immunol. 2001; 86: 633–640.
24. Szefler S.J., Eigen H. Budesonide inhalation suspension: a nebulized corticosteroid for persistent asthma. J. Allergy Clin. Immunol. 2002; 109 (4): 730–742.
25. Guilbert T.W., Morgan W.J., Zeiger R.S. et al. Long term inhaled corticosteroids in preschool children at high risk for asthma. NEJM. 2006; 354: 1985–1997.
Рецензия
Для цитирования:
Вишнева Е., Намазова-Баранова Л., Торшхоева Р., Левина Ю., Алексеева А., Эфендиева К. ПРИМЕНЕНИЕ БУДЕСОНИДА У ДЕТЕЙ ДОШКОЛЬНОГО ВОЗРАСТА. Вопросы современной педиатрии. 2010;9(1):76-80.
For citation:
Vishneva E., Namazova-Baranova L., Torshkhoeva R., Levina Yu., Alekseeva A., Efendieva K. BUDESONIDE TREATMENT IN CHILDREN PRESCHOOL AGE. Current Pediatrics. 2010;9(1):76-80.
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