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NEW OPPORTUNITIES IN TREATMENT OF SEVERE SYSTEMIC TYPE OF JUVENILE ARTHRITIS

Abstract

The article presents a case report of a severe clinical course of systemic type of juvenile arthritis, resistant to treatment with corticosteroids and classic immunosuppressive agents in girl 9 years old. Biological agent — tocilizumab showed beneficial effect: exudative lesions of joints, morning joint stiffness stopped and the range of motions restored in almost all affected joints in 8 weeks of treatment. A girl became more active, her emotional state improved. Laboratory signs of disease’s activity (ESR, concentration of C-reactive protein in plasma) were normalized in 4 weeks. The drug induced development of clinical and laboratory remission of a disease.
Key words: children, juvenile arthritis, treatment, tocilizumab.
(Voprosy sovremennoi pediatrii — Current Pediatrics. – 2010;9(4):160-167)

About the Authors

R.V. Denisova
Scientific Center of Children’s Health, Russian Academy of Medical Sciences, Moscow
Russian Federation


E.I. Alexeeva
Scientific Center of Children’s Health, Russian Academy of Medical Sciences, Moscow
Russian Federation


A.O. Lisitsin
Scientific Center of Children’s Health, Russian Academy of Medical Sciences, Moscow
Russian Federation


S.I. Valieva
Scientific Center of Children’s Health, Russian Academy of Medical Sciences, Moscow
Russian Federation


T.M. Bzarova
Scientific Center of Children’s Health, Russian Academy of Medical Sciences, Moscow
Russian Federation


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Review

For citations:


Denisova R., Alexeeva E., Lisitsin A., Valieva S., Bzarova T. NEW OPPORTUNITIES IN TREATMENT OF SEVERE SYSTEMIC TYPE OF JUVENILE ARTHRITIS. Current Pediatrics. 2010;9(4):160-167.

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