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TREATMENT WITH INFLIXIMAB IN PATIENT WITH EARLY POLYARTICULAR JUVENILE RHEUMATOID ARTHRITIS

Abstract

The article presents a case report of severe polyarticular juvenile rheumatoid arthritis (JRA) resistant to treatment with corticosteroids and classic immunosuppressive agents. Authors describe successful treatment with genetically engineered biological agent — infliximab in patient with early arthritis (duration of disease in less than two years): at 1st week of treatment pain and morning stiffness were stopped, and exudative lesions of joint significantly decreased. Inactive phase of disease was reached in 6 weeks, and movements in 8 of 9 joints were restored. Oral prednisolone was stopped. This case report shows high effectiveness of infliximab in patient with early JRA. Therapeutic treatment of early stages of disease before development of irreversible osteocartilaginous destruction with blocker of tumor necrotizing factor is very perspective.
Key words: children, early juvenile rheumatoid arthritis, treatment, infliximab.
(Voprosy sovremennoi pediatrii — Current Pediatrics. 2010;9(5):127-132)

About the Authors

T.V. Sleptsova
Scientific Center of Children’s Health, Russian Academy of Medical Sciences, Moscow
Russian Federation


E.I. Alexeeva
Scientific Center of Children’s Health, Russian Academy of Medical Sciences, Moscow I.M. Sechenov 1st Moscow State Medical University
Russian Federation


S.I. Valieva
Scientific Center of Children’s Health, Russian Academy of Medical Sciences, Moscow
Russian Federation


T.M. Bzarova
Scientific Center of Children’s Health, Russian Academy of Medical Sciences, Moscow
Russian Federation


A.O. Lisitsin
Scientific Center of Children’s Health, Russian Academy of Medical Sciences, Moscow
Russian Federation


K.B. Isaeva
Scientific Center of Children’s Health, Russian Academy of Medical Sciences, Moscow
Russian Federation


R.V. Denisova
Scientific Center of Children’s Health, Russian Academy of Medical Sciences, Moscow
Russian Federation


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Review

For citations:


Sleptsova T., Alexeeva E., Valieva S., Bzarova T., Lisitsin A., Isaeva K., Denisova R. TREATMENT WITH INFLIXIMAB IN PATIENT WITH EARLY POLYARTICULAR JUVENILE RHEUMATOID ARTHRITIS. Current Pediatrics. 2010;9(5):127-132.

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