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Вопросы современной педиатрии

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О развитии сердечно-сосудистых заболеваний при нарушениях сна у детей

https://doi.org/10.15690/vsp.v14i6.1471

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Аннотация

Сердечно-сосудистые заболевания (ССЗ) — одна из главных причин высокой смертности во всех странах мира. В последние годы значимость сосудистых поражений сердца и головного мозга в структуре причин смерти подростков возросла. Основным фактором риска фатальных исходов и тяжелых жизнеугрожающих осложнений ССЗ является избыточный вес и, в частности, ожирение. За последние 20 лет распространенность этого фактора риска среди детей в возрасте 6–11 лет увеличилась вдвое, среди подростков 12–19 лет — в 3 раза. Ожидается, что актуальность проблемы в будущем только увеличится. На протяжении последних 40 лет активно изучали связь ожирения с нарушением дыхания во время сна. При этом синдром обструктивного апноэ/гипопноэ сна рассматривают как одну из основных причин развития сердечно-сосудистых катастроф у взрослых. В настоящем обзоре представлены результаты анализа проблемы развития ССЗ при нарушениях сна с оценкой педиатрического аспекта этой проблемы.

Об авторах

О. В. Кожевникова
Научный центр здоровья детей, Москва, Российская Федерация
Россия

кандидат медицинских наук, врач высшей категории, заведующая отделением инструментальной и лабораторной диагностики КДЦ НЦЗД Адрес: 119991 Москва, Ломоносовский проспект, д. 2, стр. 1, тел.: +7 (495) 967-14-20



Л. С. Намазова-Баранова
Научный центр здоровья детей, Москва, Российская Федерация Первый Московский государственный медицинский университет им. И.М. Сеченова, Москва, Российская Федерация Российский национальный исследовательский медицинский университет им. Н.И. Пирогова, Москва, Российская Федерация
Россия


Э. А. Абашидзе
Научный центр здоровья детей, Москва, Российская Федерация
Россия


В. В. Алтунин
Научный центр здоровья детей, Москва, Российская Федерация
Россия


В. В. Лебедев
Научный центр здоровья детей, Москва, Российская Федерация
Россия


Список литературы

1. De Torres-Alba F, Gemma D, Armada-Romero E, Rey-Blas JR, Lopez-de-Sa E, Lopez-Sendon JL. Obstructive Sleep Apnea and Coronary Artery Disease: From Pathophysiology to Clinical Impli cations. Pulm Med. 2013;2013:768064.

2. Абашидзе ЭА, Намазова-Баранова ЛС, Кожевникова ОВ, Алтунин ВВ, Геворкян АК. Оценка качества и структуры сна у детей с патологией ЛОР-органов, бронхиальной астмой и наиболее распространенными болезнями нервной системы. Педиатрическая фармакология. 2013;10(2):87–91.

3. Аллергия у детей: от теории — к практике. Под ред. ЛС Намазовой-Барановой. М. 2011. С. 268–474.

4. Баранов АА. Профилактика расстройств сна у детей и подростков. Научно-практическая программа Союза педиатров России. М. 2006. 103 с.

5. Ковальзон ВМ. Нейрохимия сна и сновидений. Нейрохимия. 1999;16(1):157–160.

6. Mindell JA, Owens J. Pediatric sleep. Diagnosis and management of sleep problems. NY. 2010. 232 р.

7. Anders TF, Sadeh A, Appareddy V. Normal sleep in neonates and children. In: Ferber R, Kryger M. Principles and practice of sleep medicine in the child. Philadelphia: WB Saunders. 1995. Р. 7–18.

8. Rechtshaffen A, Kales A. Manual of Standardized Terminology, Techniques, and Criteria for the Scoring of Stages of Sleep and Wake fullness of Human Subjects. Washington: Government Printing Office. 1968. № 204.

9. Stein M, Mendelsohn J, Obermeyer W, Benca R. Sleep and behavior problems in school aged children. Pediatrics. 2001;107(4):60.

10. Abad VC, Guilleminault C. Sleep and psychiatry. Dialogues in clinical neuroscience. 2005;7(4):291–303.

11. Melendres MC, Lutz JM, Rubin ED, Marcus CL. Daytime sleepiness and hyperactivity in children with suspected sleep disordered breathing. Pediatrics. 2004;114:768–775.

12. Струева НВ, Полуэктов МГ, Савельева ЛА, Мельниченко ГА. Ожирение и сон. URL: http://dx.doi.org/10.14341/2071-8713-3860 (дата обращения: 16.07.2015).

13. Capuccio F, Taggart F, Kandala N, Urrie A, Peile E, Strangers S, Miller A. Meta-analysis of short sleep duration and obesity in children and adults. Sleep. 2008;31(5):619–626.

14. Gronfier C, Luthringer R, Follenius MA. Obstructive sleep apnea syndrome is associated with delayed growth. A quantitative evaluation of the relationship between growth hormone secretion and delta wave electroencephalographic activity during normal sleep and after enrichment in delta waves. Sleep. 1996;19:817–824.

15. Gozal D, Pope DW. Snoring during early childhood and academic performance at ages 13–14 years. Pediatrics. 2001;107:1394–1399.

16. Montgomery-Downs HE, O’Brien LM, Holbrook R, Gozal D. Snoring and sleep disordered breathing in young children: subjective and objective correlates. Sleep. 2004;27:87–94.

17. American academy of sleep Medicine. Task force sleep related breathing disorder in adult. Sleep. 1999;22(5):667–689.

18. Guilleminault C, Tilkian A, Dement WC. The sleep apnea syndromes. Am Rev Med. 1976;27:465–484.

19. Lumeng JC, Chervin RD. Epidemiology of pediatric obstructive sleep apnea. Proc Am Thorac Soc. 2008;5(2):242–252.

20. Corbo G, Fuciarelli F, Foresi A, Benedetto AF. Snoring in children: association with respiratory 6sympthoms and passive smoking. BMJ. 1989;299:1491–1494.

21. Montgomery-Downs HE, Thoman EB. Biological and behavioral correlates of quiet sleep respiration rates in infants. Physiology and Behavior. 1998;64(5):637–643.

22. Hendeles-Amitai A., Kozminsky E. Adenotonsillectomy improves neurocognitive function in children with obstructive sleep apnea syndrome. Sleep. 2003;26:999–1005.

23. Русецкий ЮЮ, Черниченко ИО, Седых ТК. 10-летний опыт эндоскопической органосохраняющей аденотомии. Российская ринология. 2012;3:4–7.

24. Бабак СЛ, Чучалин АГ. Нарушения сна. Русский медицинский журнал. 2006;14:16.

25. Klink M, Quan SF. Prevalence of reported sleep disturbances in a general adult population and their relationship to obstructive airways disease. Chest.1987;91:540–546.

26. Ancoli-Israel S, DuHamel ER, Stepnowsky C, Engler R, Cohen-Zion M, Marler M. The relationship between congestive heart failure, sleep apnea, and mortality in older men. Chest. 2003; 124:1400–1405.

27. Leung RS, Bradley TD. Sleep apnea and cardiovascular disease. Am J Respir Crit Care Med. 2001;164:2147–2165.

28. Haas DC, Foster GL, Nieto FJ, Redline S, Resnick HE, Robbins JA, Young T, Pickering TG. Age dependent associations between sleep disordered breathing and hypertension: importance of discriminating between systolic/diastolic hypertension and isolated systolic hypertension in the Sleep Heart Health Study. Circulation. 2005;111:614–621.

29. Kohyama J, Ohinata JS, Hasegawa T. Blood pressure in sleep disordered breathing. Arch Dis Child. 2003;88:139–142.

30. Lopez-Jimenez F, Sert Kuniyoshi FHS, Gami A, Somers VK. Obstruc tive sleep apnea: implications for cardiac and vascular disease. Chest. 2008;133:793–804.

31. Kapa S, Sert Kuniyoshi FH, Somers VK. Sleep apnea and hypertension: interactions and implications for management. Hypertension. 2008;51:605–608.

32. Kim NH. Obstructive sleep apnea and abnormal glucose metabolism. Diabet Metab J. 2012;36(4):268–272.

33. O`Driscoll DM, Horne RS, Davey MJ, Hope SA, Anderson V, Trinder J. Increased sympathetic activity in children with obstruc tive sleep apnea: Cardiovascular implications. Sleep Med. 2011;12(5):483–488.

34. Kelly A, Marcus CL. Childhood obesity, inflammation, and apnea: what is the future for our children? Am J Respir Crit Care Med. 2005;171:202–203.

35. Narkiewicz K, van de Borne PJ, Somers VK, Dyken ME. Sympathetic activity in obese subjects with and without obstructive sleep apnea. Circulation. 1998;98:772–776.

36. Peled N, Abinader EG, Pillar G, Sharif D, Lavie P. Nocturnal ischemic events in patients with obstructive sleep apnea syndrome and ischemic heart disease: effects of continuous positive air pressure treatment. J Am Coll Cardiol. 1999;34:1744–1749.

37. Somers VK, White DP, Amin R, Abraham WT, Costa F, Culebras A, Daniels S, Floras JS, Hunt CE, Olson LJ, Pickering TG, Russell R, Woo M, Young T. Sleep apnea and cardiovascular disease. J Am Coll Cardiol. 2008;52(8):686–717.

38. NSpiegel K, Knutson K, Leproult R, Tasali E, Van Cauter E. Sleep loss: a novel risk factor for insulin resistance and type 2 diabetes. Appl Physiol. 2005;99:2008–2019.

39. Coughlin SR, Mawdsley L, Mugarza JA. Calverley PM, Wilding JP. Obstructive sleep apnoea is independently associated with an increased prevalence of metabolic syndrome. Eur Heart J. 2004; 25:735–741.

40. Lavie P, Ben-Yosef R, Rubin AE. Prevalence of sleep apnea syndrome among patients with essential hypertension. Am Heart J. 1984;108:373–376.

41. Punjabi NM, Shahar E, Redline S. Gottlieb DJ, Givelber R, Resnick HE. Sleep Heart Health Study Investigators. Sleep disordered breathing, glucose intolerance, and insulin resistance: the Sleep Heart Health Study. Am J Epidemiol. 2004;160:521–530.

42. Guilleminault C, Connolly SJ, Winkle RA. Cardiac arrhythmia and conduction disturbances during sleep in 400 patients with sleep apnea syndrome. Am J Cardiol. 1983;52:490–494.

43. Ip MS, Lam B, Ng MM, Lam WK, Tsang KW, Lam KS. Obstructive sleep apnea is independently associated with insulin resistance. Am J Respir Crit Care Med. 2002;165(5):670–676.

44. Al-Delaimy WK, Manson JE, Willett WC, Stampfer MJ, Hu FB. Snoring as a risk factor for type II diabetes mellitus: a prospective study. Am J Epidemiol. 2002;155:387–393.

45. Inkster B, Riha RL, Van Look L, Williamson R, McLachlan S, Frier BM, Strachan MW, Price JF, Reynolds RM. Association between excessive daytime sleepiness and severe hypoglycemia in people with type 2 diabetes: the Edinburgh Type 2 Diabetes Study. Diabetes Care. 2013;36(12):4157–4159.

46. Harsch IA, Schahin SP, Bruckner K, Radespiel-Troger M, Fuchs FS, Hahn EG, Konturek PC, Lohmann T, Ficker JH. The effect of continuous positive airway pressure treatment on insulin sensitivity in patients with obstructive sleep apnoea syndrome and type 2 diabetes. Respiration. 2004;71:252–259.

47. Arzt M, Young T, Finn L, Skatrud JB, Ryan CM, Newton GE, Mak S, Parker JD, Floras JS, Bradley TD. Sleepiness and sleep in patients with both systolic heart failure and obstructive sleep apnea. Arch Intern Med. 2006;166:1716–1722.

48. Bhattacharjee R, Kim J, Alotaibi W. Endotelial dysfunction in non–hypertensive children: potential contribution of obesity and obstructive sleep apnea. Chest. 2011;141:682–791.

49. Ip MS, Tsang KW, Lam WK. Endothelial function in obstructive sleep apnea and response to treatment. Am J Respir Crit Care Med. 2004;169:348–353.

50. Amin RS, Carroll JL, Jeffries JL, Grone C, Bean J.A, Chini B, Bokulic R, Daniels SR. Twenty–four hour ambulatory blood pressure in children with sleep disordered breathing. Am J Respir Crit Care Med. 2004;169:950–956.

51. Leung LC, Ng DK, Lau MW, Chan CH, Kwok KL, Chow PY, Cheung JM. Twenty-four hour ambulatory BP in snoring children with obstructive sleep apnea syndrome. Chest. 2006;130:1009–1017.

52. Narkiewicz K, Montano N, Cogliati C, van de Borne PJ, Dyken ME, Somers VK. Altered cardiovascular variability in obstructive sleep apnea. Circulation. 1998;98:1071–1077.

53. Кожевникова ОВ, Намазова-Баранова ЛС, Абашидзе ЭА, Алтунин ВВ, Балабанов АС, Широкова ИВ, Кондрахина ИИ, Полу нина ТА, Маргиева ТВ. Синдром обструктивного апноэ сна у детей как риск развития сердечно-сосудистой патологии. Вестник РАМН. 2015;1:32–40.

54. Lloyd-Jones DM, Wang TJ, Leip EP, Larson MG, Levy D, Vasan RS, D’Agostino RB, Massaro JM, Beiser A, Wolf PA, Benjamin EJ. Lifetime risk for development of atrial fibrillation: the Framingham Heart Study. Circulation. 2004;110:1042–1046.

55. Lesske J, Fletcher EC, Bao G, Unger T. Hypertension caused by chronic intermittent hypoxia: influence of chemoreceptors and sympathetic nervous system. J Hypertens. 1997;15:1593–1603.

56. Lavie L. Obstructive sleep apnoae syndrome: an oxidative stress disorder. Sleep Med Rev. 2003;7:35–38.

57. Phillips BG, Narkiewicz K, Pesek CA, Haynes WG, Dyken ME, Somers VK. Effects of obstructive sleep apnea on endothelin-1 and blood pressure. J Hypertens. 1999;17:61–66.

58. Fung JW, Li TS, Choy DK, Yip GW, Ko FW, Sanderson JE, Hui DS. Severe obstructive sleep apnea is associated with left ventricular diastolic dysfunction. Chest. 2002;121:422–429.

59. Portaluppi F, Provini F, Cortelli P, Plazzi G, Bertozzi N, Manfredini R, Fersini C, Lugaresi E. Undiagnosed sleep disordered breathing among male nondippers with essential hypertension. J Hypertens. 1997;15:1227–1233.

60. Gjorup PH, Sadauskiene L, Wessels J, Nyvad O, Strunge B, Pedersen EB. Abnormally increased endothelin-1 in plasma during the night in obstructive sleep apnea: relation to blood pressure and severity of disease. Am J Hypertens. 2007;20:44–52.

61. Randazo DN, Winters SL, Schweitzer P. Obstructive sleep apnea-induced supraventricular tachycardia. J Electrocardiol. 1996; 29:65–67.

62. Liston R, Deegan PC, McCreery C, McNicholas WT. Role of respiratory sleep disorders in the pathogenesis of nocturnal angina and arrhythmias. Postgrad Med J. 1994;70:275–280.

63. Ben-Dov IZ, Kark JD, Ben-Ishay D, Mekler J, Ben-Arie L, Bursztyn M. Predictors of all cause mortality in clinical ambulatory monitoring: unique aspects of blood pressure during sleep. Hypertension. 2007;49:1235–1241.

64. Javaheri S. Effects of continuous positive airway pressure on sleep apnea and ventricular irritability in patients 67 with heart failure. Circulation. 2000;101:392–397.

65. Sorajja D, Gami AS, Somers VK, Behrenbeck TR, Garcia- Touchard A, Lopez-Jimenez F. Independent association between obstructive sleep apnea and subclinical coronary artery disease. Chest. 2008:133:927–933.

66. Goodwin JL, Enright PL, Kaemingk KL, Rosen GM, Morgan WJ, Fregosi RF. Feasibility of using unattended polysomnography in children for research report of the Tucson Children’s Assessment of Sleep Apnea study (TuCASA). Sleep. 2001; 24(8):937–944.

67. Tam CS, Wong M, McBain R, Bailey S, Waters KA. Inflammatory measures in children with obstructive sleep apnoea. Child Health. 2006;42:277–282.

68. Kwork KL, Ng DK, Cheung YF. BP and arterial distensibility in children with primary snoring. Chest. 2003;123:1561–1566.

69. Kirk V, Midgley J, Giuffre M, Ronksley P, Nettel-Aguirre A, Al-Shamrani A. Hypertension and obstructive sleep apnea in Caucasian children. World J Cardiol. 2010;2(8):251–256.

70. Minoguchi K, Yokoe T, Tazaki T, Minoguchi H, Oda N, Tanaka A, Yamamoto M, Ohta S, O’Donnell CP, Adachi M. Silent brain infarction and platelet activation in obstructive sleep apnea. Am J Respir Crit Care Med. 2007;175:612–617.

71. Redline S, Yenokyan G, Gottlieb DJ, Shahar E, O’Connor GT, Resnick HE, Diener-West M, Sanders MH, Wolf PA, Geraghty EM, Ali T, Lebowitz M, Punjabi NM. Obstructive sleep apnea-hypopnea and incident stroke: the sleep heart health study. Am J Respir Crit Care Med. 2010;182(2):269–277. Doi: 10.1164/rccm.200911- 1746OC.

72. Marcus CL, Greene MG, Carroll JL. Blood pressure in children with obstructive sleep apnea. Am J Respir Crit Care Med. 1998; 157:1098–1103.

73. Мадаева ИМ, Шавырталова ОН, Долгих ВВ. Артериальная гипертензия и нарушения дыхания во время сна в педиатрии: результаты пилотного исследования. Педиатрия. Сonsilium medicum. 2009;3.

74. Amin R, Somers VK, McConnell K, Willging P, Myer C, Sherman M, McPhail G, Morgenthal A, Fenchel M, Bean J, Kimball T, Daniels S. Activity adjusted 24 hour ambulatory blood pressure and cardiac remodeling in children with sleep disordered breathing. Hypertension. 2008;51:84–91.

75. Archbold KH, Pituch KJ, Panahi P. Chervin RD. Symptoms of sleep disturbances among children at two general pediatrics clinics. J Pediatr. 2002;140:97–102.

76. Peppard PE, Young T, Palta M, Skatrud J. Prospective study of the association between sleep disordered breathing and hypertension. N Engl J Med. 2000;342:1378–1384.

77. Soukhova O`Hare G.K., Roberts A.M., Gozal D. Impaired control of renal sympathetic nerve activity following neonatal intermittent hypoxia in rats. Neurosci Lett. 2006;399(3):181–185.

78. Лаптев ДН, Шмушкович ИА. Аритмогенный эффект гипогликемии. Сахарный диабет. 2012;1:25–30.

79. Рябыкина ГВ, Лаптев ДН, Соболев АВ, Сеид-Гуссейнов АА, Волков ИЭ. Исследование интервала Q–T у детей и подростков, больных сахарным диабетом 1 типа, при холтеровском мониторировании ЭКГ. Сахарный диабет. 2007;2:19–23.


Для цитирования:


Кожевникова О.В., Намазова-Баранова Л.С., Абашидзе Э.А., Алтунин В.В., Лебедев В.В. О развитии сердечно-сосудистых заболеваний при нарушениях сна у детей. Вопросы современной педиатрии. 2015;14(6):638-644. https://doi.org/10.15690/vsp.v14i6.1471

For citation:


Kozhevnikova O.V., Namazova-Baranova L.S., Abashidze E.A., Altunin V.V., Lebedev V.V. On the Development of Cardiovascular Diseases in Children with Sleep Disorders. Current Pediatrics. 2015;14(6):638-644. (In Russ.) https://doi.org/10.15690/vsp.v14i6.1471

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