APPLICABILITY OF A HUMAN LACTOFERRIN IN PEDIATRIC PRACTICE
https://doi.org/10.15690/vsp.v13i4.1079
Abstract
Modern data on efficiency and safety of a recombinant human lactoferrin (hLf) and prospects of its use in pediatric practice are presented in the review of literary data. The unique anti-infectious properties of biologically active protein of the hLf, its high antimicrobic, antiviral, antifungal and anti-parasitic activity are noted. Ability to stimulate natural immunity, to interact with other antimicrobic peptides, in particular, with lysozyme and secretory leukocyte protease inhibitor is analysed. In this regard it is indicated prospects of application of the hLf in treatment of prematurely born and hypotrophic children, patients with chronic nutritional deficiency for the purpose of prevention of infectious diseases and correction of inflammatory changes in the organism of a child, including
acute respiratory virus and enteric infections in children. It is expedient to apply hLf in surgical practice for reduction of a degree of manifestation of the acute pro-inflammatory response, and also for prevention of infectious complications, especially after abdominal operations, in complex treatment of children with a severe generalized infection and multi-organ failure, for prevention of intrahospital nosocomial infections in children hospitals.
Key words: children, prematurely born, nutritional deficiency, infections, lactoferrin, recombinant human lactoferrin.
acute respiratory virus and enteric infections in children. It is expedient to apply hLf in surgical practice for reduction of a degree of manifestation of the acute pro-inflammatory response, and also for prevention of infectious complications, especially after abdominal operations, in complex treatment of children with a severe generalized infection and multi-organ failure, for prevention of intrahospital nosocomial infections in children hospitals.
Key words: children, prematurely born, nutritional deficiency, infections, lactoferrin, recombinant human lactoferrin.
About the Authors
T. E. Borovik
Scientific Centre of Children Health
Russian Federation
Borovik Tat'yana Eduardovna, PhD, professor, Head of the Department of Healthy and Ill Child’s Nutrition
Russian Federation
Borovik Tat'yana Eduardovna, PhD, professor, Head of the Department of Healthy and Ill Child’s Nutrition
G. V. Yatsyk
Scientific Centre of Children Health
Russian Federation
Russian Federation
L. S. Namazova-Baranova
Scientific Centre of Children Health
I.M. Sechenov First Moscow State Medical University;
Pirogov Russian National Research Medical University, Moscow
Russian Federation
Russian Federation
N. G. Zvonkova
Scientific Centre of Children Health
Russian Federation
Russian Federation
N. N. Semenova
Scientific Centre of Children Health
Russian Federation
Russian Federation
О. L. Lukoyanova
Scientific Centre of Children Health
Russian Federation
Russian Federation
P. E. Sadchikov
Scientific Centre of Children Health
Russian Federation
Russian Federation
I. L. Gol'dman
Institute of Gene Biology of the Russian Academy of Sciences, Moscow
Russian Federation
Russian Federation
E. R. Sadchikova
Institute of Gene Biology of the Russian Academy of Sciences, Moscow
Russian Federation
Russian Federation
I. А. Belyaeva
Scientific Centre of Children Health
Russian Federation
Russian Federation
T. V. Bushueva
Scientific Centre of Children Health
Russian Federation
Russian Federation
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Review
For citations:
Borovik T.E., Yatsyk G.V., Namazova-Baranova L.S., Zvonkova N.G., Semenova N.N., Lukoyanova О.L., Sadchikov P.E., Gol'dman I.L., Sadchikova E.R., Belyaeva I.А., Bushueva T.V. APPLICABILITY OF A HUMAN LACTOFERRIN IN PEDIATRIC PRACTICE. Current Pediatrics. 2014;13(4):12-19. (In Russ.) https://doi.org/10.15690/vsp.v13i4.1079
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