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Опыт применения ритуксимаба у детей с системной красной волчанкой: ретроспективное исследование серии случаев

https://doi.org/10.15690/vsp.v15i3.1567

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Аннотация

Системная красная волчанка (СКВ) у детей отличается непредсказуемым и тяжелым течением. Стандарта терапии заболевания в настоящее время не существует. В статье представлены результаты ретроспективного исследования эффективности ритуксимаба у 16 детей с СКВ в возрасте от 5 до 16 лет, находившихся на стационарном лечении. Ритуксимаб назначали пациентам с тяжелым жизнеугрожающим течением болезни при неэффективности гормонально-цитостатической терапии или невозможности снижения суточной дозы кортикостероидов. Доза вводимого препарата составляла 375 мг/м2 еженедельно в течение 4 нед. На фоне терапии ритуксимабом отмечено клинически значимое снижение значений лабораторных показателей активности заболевания, индексов активности болезни SLEDAI, ECLAM, индекса повреждения SLICC/ACR, а также суточной дозы кортикостероидов. Зафиксированы один случай пневмонии и 2 летальных исхода, наступивших на фоне присоединения генерализованной микотической инфекции.

Об авторах

М. М. Костик
Санкт-Петербургский государственный педиатрический медицинский университет, Санкт-Петербург, Российская Федерация
Россия

кандидат медицинских наук, доцент кафедры госпитальной педиатрии Санкт-Петербургского государственного педиатрического медицинского университета Адрес: 194100, Санкт-Петербург, ул. Литовская, д. 2, тел.: +7 (812) 416-52-98



Е. М. Кучинская
Санкт-Петербургский государственный педиатрический медицинский университет, Санкт-Петербург, Российская Федерация
Россия


Ф. Н. Абдурагимова
Санкт-Петербургский государственный педиатрический медицинский университет, Санкт-Петербург, Российская Федерация
Россия


О. П. Гурина
Санкт-Петербургский государственный педиатрический медицинский университет, Санкт-Петербург, Российская Федерация
Россия


О. В. Калашникова
Санкт-Петербургский государственный педиатрический медицинский университет, Санкт-Петербург, Российская Федерация
Россия


В. Г. Часнык
Санкт-Петербургский государственный педиатрический медицинский университет, Санкт-Петербург, Российская Федерация
Россия


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Для цитирования:


Костик М.М., Кучинская Е.М., Абдурагимова Ф.Н., Гурина О.П., Калашникова О.В., Часнык В.Г. Опыт применения ритуксимаба у детей с системной красной волчанкой: ретроспективное исследование серии случаев. Вопросы современной педиатрии. 2016;15(3):295-300. https://doi.org/10.15690/vsp.v15i3.1567

For citation:


Kostik M.M., Kuchinskaya E.M., Abduragimova F.N., Gurina O.P., Kalashnikova O.V., Chasnyk V.G. Experience in Rituximab Administration in Children with Systemic Lupus Erythematosus: a Retrospective Study of the Case Series. Current pediatrics. 2016;15(3):295-300. (In Russ.) https://doi.org/10.15690/vsp.v15i3.1567

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