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Современные представления о патогенезе и принципах наружной терапии атопического дерматита у детей

https://doi.org/10.15690/vsp.v15i6.1655

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Аннотация

статье анализируются современные данные о патогенезе атопического дерматита. Обсуждается роль нарушения структуры дермального барьера в развитии пищевой аллергии, приводятся результаты, подтверждающие теорию чрескожной сенсибилизации к аллергенам наряду с наследственными и экзогенными факторами. Современная локальная терапия атопического дерматита с использованием топических глюкокортикостероидов (тГКС), направленная на уменьшение выраженности симптомов заболевания, зачастую сопряжена с риском развития осложнений. Приводятся данные об эффективном использовании топических ингибиторов кальциневрина (тИК) в качестве средств, нивелирующих побочные эффекты тГКС. Продемонстрированы результаты возможного применения пимекролимуса в виде 1% крема с целью постепенной отмены тГКС при долгосрочном использовании. Представлены данные обзоров и метаанализов за последнее десятилетие, демонстрирующие, что не существует никаких доказательств того, что использование тИК связано с повышенным риском развития лимфомы. Авторами сделан вывод, что пимекролимус в виде 1% крема является оптимальным средством топической терапии у детей с легкой и среднетяжелой формой заболевания, а также препаратом для проактивной терапии атопического дерматита в течение длительного периода времени с целью предотвращения обострений.

Об авторах

Н. Н. Мурашкин
Научный центр здоровья детей Первый Московский государственный медицинский университет им. И.М. Сеченова
Россия

доктор медицинских наук, заведующий отделением дерматологии НЦЗД, профессор кафедры педиатрии и детской ревматологии 1 МГМУ им. И.М. Сеченова Адрес: 119991, Москва, Ломоносовский пр-т, д. 2, стр. 1, тел.: +7 (499) 134-08-89



А. И. Материкин
Научный центр здоровья детей
Россия
Москва, Российская Федерация


Э. Т. Амбарчян
Научный центр здоровья детей
Россия
Москва, Российская Федерация


Р. В. Епишев
Научный центр здоровья детей
Россия
Москва, Российская Федерация


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Для цитирования:


Мурашкин Н.Н., Материкин А.И., Амбарчян Э.Т., Епишев Р.В. Современные представления о патогенезе и принципах наружной терапии атопического дерматита у детей. Вопросы современной педиатрии. 2016;15(6):584-589. https://doi.org/10.15690/vsp.v15i6.1655

For citation:


Murashkin N.N., Materikin A.I., Ambarchyan E.T., Epishev R.V. Current Views on the Pathogenesis and Principles of External Treatment of Atopic Dermatitis in Children. Current Pediatrics. 2016;15(6):584-589. (In Russ.) https://doi.org/10.15690/vsp.v15i6.1655

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