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Онтогенез и дизонтогенез микробиоты кишечника у детей раннего возраста: триггерный механизм нарушений детского здоровья

https://doi.org/10.15690/vsp.v16i1.1692

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Аннотация

В статье представлен анализ исследований, в которых изучались становление и развитие микрофлоры (микробиоты) кишечника у детей и ее патогенетическая роль. Приведено описание этапов колонизации кишечника младенца, механизмов взаимовлияния микробиот младенца и матери. Показана связь динамики становления микробиоты ребенка с характером вскармливания; отмечена саногенетическая роль грудного вскармливания в отношении микрофлоры младенца. Представлены связь качественных и количественных характеристик микробиоты с отсроченными рисками развития метаболических и аллергических заболеваний. Особое внимание уделено анализу вли-
яния антибиотиков на становление микробиоты, в том числе у недоношенных детей. В статье представлены современные подходы к коррекции нарушений кишечной микробиоты препаратами-пробиотиками, обоснованы методы выбора пробиотиков. Одним из таких препаратов является зарегистрированный в России пробиотик, содержащий Bifidobacterium lactis BB-12 и Streptococcus thermophilus, который успешно используется для коррекции дисбиоза у новорожденных младенцев, в т. ч. у недоношенных.

Об авторах

И. А. Беляева
Национальный научно-практический центр здоровья детей
Россия
доктор медицинских наук, профессор РАН, профессор кафедры РНИМУ им. Н.И. Пирогова, заведующая отделением для недоношенных детей ННПЦЗД


Е. П. Бомбардирова
Национальный научно-практический центр здоровья детей
Россия


М. Д. Митиш
Национальный научно-практический центр здоровья детей
Россия


Т. В. Потехина
Национальный научно-практический центр здоровья детей
Россия


Н. А. Харитонова
Национальный научно-практический центр здоровья детей
Россия


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Для цитирования:


Беляева И.А., Бомбардирова Е.П., Митиш М.Д., Потехина Т.В., Харитонова Н.А. Онтогенез и дизонтогенез микробиоты кишечника у детей раннего возраста: триггерный механизм нарушений детского здоровья. Вопросы современной педиатрии. 2017;16(1):29-38. https://doi.org/10.15690/vsp.v16i1.1692

For citation:


Belyaeva I.A., Bombardirova E.P., Mitish M.D., Potekhina T.V., Kharitonova N.A. Ontogenesis and Dysontogenesis of the Gut Microbiota in Young Children: a Trigger Mechanism of Child Health Disorders. Current pediatrics. 2017;16(1):29-38. (In Russ.) https://doi.org/10.15690/vsp.v16i1.1692

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