ABNORMAL UTERINE BLEEDING IN ADOLESCENTS — ENDOCRINE PROFILE CONDITION
https://doi.org/10.15690/vsp.v13i4.1098
Abstract
Aim: The purpose of the study was to evaluate the endocrine profile condition in adolescent girls with abnormal uterine bleeding. Patients and methods: The participants of the study were 110 adolescent girls in the age between 11 and 15 years taken to hospital by emergency indication in the period between 2010–2013 years with dysfunctional uterine bleeding for the term from 3 to 48 days. In the first day of hospitalization before starting the hormonal therapy all patients underwent the physical examination, ultrasonic examination of pelvic organs and endocrine profile assessment. Concentration of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) and the levels of mammotropic hormone, thyrotropic hormone, estradiol, progesterone and testosterone in their blood were determined. Besides that physicians assessed the complete blood count indices: hemoglobin concentration, erythrocyte number and hematocrits. Results: It was determined that the predisposing causes of abnormal uterine bleeding development in adolescents: high somatic pathology frequency, abnormalities of neuroendocrinal system and menstrual cycle. Gynecological pathology in adolescents is represented by significant disorders of menstrual function establishment expressed in the later beginning of menstruation, its intensity and duration. The authors also note the higher frequency of inflammatory diseases such as adnexitis, edeitis, vulvovaginitis and coleitis in comparison with the control group (37.3 and 30%, respectively). Another tendency was observed while studying the endocrine profile: in patients with hyperestrogenism the normal or increased content of FSH at the normal or lowered LH concentration is observed. At the same time, in patients with hypestrogenism FSH concentration at the lower limits of the age group is lowered, while LH concentration is lowered or normal. Conclusion: Abnormal uterine bleeding in adolescents in the most cases is developing in the setting of relative hyper- or hypestrogenism and the clinical presentation of the condition depends on this indicator.
About the Authors
E. V. Sibirskaya
Scientific Center of Children’s Health, Moscow;
Moscow State University of Medicine and Dentistry named after A.I. Evdokimov;
Morozov Children’s City Clinical Hospital, Moscow
Russian Federation
Sibirskaya Elena Viktorovna, PhD, associated professor of Reproductive Medicine and Surgery Department of MSMDU, chief research scientist at the Department of Reproductive Health of Research Institute of Pediatric Surgery of SCCH, an employee of gynecological department of Morozov CCCH, chief freelance pediatric gynecologist of Central Federal District of the Russian Federation
Russian Federation
Sibirskaya Elena Viktorovna, PhD, associated professor of Reproductive Medicine and Surgery Department of MSMDU, chief research scientist at the Department of Reproductive Health of Research Institute of Pediatric Surgery of SCCH, an employee of gynecological department of Morozov CCCH, chief freelance pediatric gynecologist of Central Federal District of the Russian Federation
L. V. Adamyan
Moscow State University of Medicine and Dentistry named after A.I. Evdokimov
Russian Federation
Russian Federation
S. P. Yatsyk
Scientific Center of Children’s Health, Moscow
Russian Federation
Russian Federation
I. F. Tin
Scientific Center of Children’s Health, Moscow
Russian Federation
Russian Federation
S. G. Geras'kina
Scientific Center of Children’s Health, Moscow
Morozov Children’s City Clinical Hospital, Moscow
Russian Federation
Russian Federation
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Review
For citations:
Sibirskaya E.V., Adamyan L.V., Yatsyk S.P., Tin I.F., Geras'kina S.G. ABNORMAL UTERINE BLEEDING IN ADOLESCENTS — ENDOCRINE PROFILE CONDITION. Current Pediatrics. 2014;13(4):136-139. (In Russ.) https://doi.org/10.15690/vsp.v13i4.1098
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