Поражение почек и перинатальное программирование артериальной гипертензии: результаты экспериментальных исследований
Аннотация
Ухудшение условий развития в перинатальный период (голодание матери, избыток ионов натрия в ее рационе, воздействие глюкокортикостероидов, плацентарная недостаточность) программирует значительные изменения экскреции ионов натрия у новорожденного и ведет к развитию артериальной гипертензии. Исследования на экспериментальных животных показывают, что неблагоприятные условия внутриутробного развития могут уменьшить эффективную площадь гломерулярной фильтрации и ее скорость. Эти обстоятельства увеличивают экспрессию мембранных переносчиков ионов натрия в апикальных мембранах, продукцию супероксидных радикалов и усиливают реабсорбцию натрия. В статье обсуждаются потенциальные механизмы перинатального программирования почечной гипертензии у человека.
Об авторах
О. П. Ковтун
Уральский государственный медицинский университет
Россия
Раскрытие интересов:
Россия
Раскрытие интересов:
подтвердила отсутствие конфликта интересов, о котором необходимо сообщить
П. Б. Цывьян
Уральский государственный медицинский университет
Уральский НИИ охраны материнства и младенчества
Россия
Раскрытие интересов:
Россия
доктор медицинских наук, профессор, заведующий кафедрой нормальной физиологии УГМУ, ведущий научный сотрудник Уральского НИИ охраны материнства и младенчества
Адрес: 620028, Екатеринбург, ул. Репина д. 3, тел.: +7 (343) 214-86-79
Раскрытие интересов:
в 2013–2015 гг. участвовал в выполнении гранта РФФИ 13- 04-96080 «Исследование механизмов регуляции сердечно- сосудистой системы эмбриона и плода человека при беременности, индуцированной экстракорпоральным оплодотворением»
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Для цитирования:
Ковтун О.П., Цывьян П.Б. Поражение почек и перинатальное программирование артериальной гипертензии: результаты экспериментальных исследований. Вопросы современной педиатрии. 2017;16(6):481-486. https://doi.org/10.15690/vsp.v16i6.1820
For citation:
Kovtun O.P., Tsyvian P.B. Kidney Disease and Perinatal Programming of Arterial Hypertension: the Results of Experimental Researches. Current Pediatrics. 2017;16(6):481-486. (In Russ.) https://doi.org/10.15690/vsp.v16i6.1820
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