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Вопросы современной педиатрии

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Поражение почек и перинатальное программирование артериальной гипертензии: результаты экспериментальных исследований

https://doi.org/10.15690/vsp.v16i6.1820

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Аннотация

Ухудшение условий развития в перинатальный период (голодание матери, избыток ионов натрия в ее рационе, воздействие глюкокортикостероидов, плацентарная недостаточность)  программирует значительные изменения экскреции ионов натрия у новорожденного и ведет к  развитию артериальной гипертензии. Исследования на экспериментальных животных  показывают, что неблагоприятные условия внутриутробного развития могут уменьшить эффективную площадь гломерулярной фильтрации и ее скорость. Эти  обстоятельства увеличивают экспрессию мембранных переносчиков ионов натрия в апикальных мембранах, продукцию супероксидных радикалов и усиливают реабсорбцию натрия. В статье  обсуждаются потенциальные механизмы перинатального программирования почечной гипертензии у человека.

Об авторах

О. П. Ковтун
Уральский государственный медицинский университет
Россия


П. Б. Цывьян
Уральский государственный медицинский университет Уральский НИИ охраны материнства и младенчества
Россия

доктор медицинских наук, профессор, заведующий кафедрой нормальной физиологии УГМУ, ведущий научный сотрудник Уральского НИИ охраны материнства и младенчества

Адрес: 620028, Екатеринбург, ул. Репина д. 3, тел.: +7 (343) 214-86-79



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Для цитирования:


Ковтун О.П., Цывьян П.Б. Поражение почек и перинатальное программирование артериальной гипертензии: результаты экспериментальных исследований. Вопросы современной педиатрии. 2017;16(6):481-486. https://doi.org/10.15690/vsp.v16i6.1820

For citation:


Kovtun O.P., Tsyvian P.B. Kidney Disease and Perinatal Programming of Arterial Hypertension: the Results of Experimental Researches. Current pediatrics. 2017;16(6):481-486. (In Russ.) https://doi.org/10.15690/vsp.v16i6.1820

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