Kidney Disease and Perinatal Programming of Arterial Hypertension: the Results of Experimental Researches
https://doi.org/10.15690/vsp.v16i6.1820
Abstract
Deterioration of development conditions in the perinatal period (starvation of the mother, excess sodium ions in her diet, exposure to glucocorticosteroids, placental insufficiency) programs significant changes in the excretion of sodium ions in the newborn and leads to the development of hypertension. Studies on experimental animals show that unfavourable conditions of intrauterine development can reduce the effective area of glomerular filtration and its rate. These circumstances increase the expression of membrane carriers of sodium ions in the apical membranes, the production of superoxide radicals and enhance the reabsorption of sodium. The article discusses the potential mechanisms of perinatal programming of renal hypertension in humans.
About the Authors
Olga P. Kovtun
Ural State Medical University
Russian Federation
Disclosure of interest:
Russian Federation
Disclosure of interest:
confirmed the absence of a reportable conflict of interests
Pavel B. Tsyvian
Ural State Medical University
Ural Research Institute for Maternal and Infant Childhood Protection
Russian Federation
Disclosure of interest:
Russian Federation
Disclosure of interest:
during 2013–2015 was a recipient of grant from Russian Foundation of Basic Research (RFBR) #13-04-96080 «Research of cardiovascular function regulation in human embryo and fetus conceived by in vitro fertilization technology»
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For citations:
Kovtun O.P., Tsyvian P.B. Kidney Disease and Perinatal Programming of Arterial Hypertension: the Results of Experimental Researches. Current Pediatrics. 2017;16(6):481-486. (In Russ.) https://doi.org/10.15690/vsp.v16i6.1820
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