АБАТАЦЕПТ В ЛЕЧЕНИИ ЮВЕНИЛЬНОГО ИДИОПАТИЧЕСКОГО АРТРИТА: ДАННЫЕ МЕЖДУНАРОДНЫХ ИССЛЕДОВАНИЙ И ОПЫТ ИСПОЛЬЗОВАНИЯ В РЕСПУБЛИКЕ МОРДОВИЯ
Аннотация
Предлагаем обзор современных представлений о месте абатацепта в лечении ювенильного идиопатического артрита с акцентом на высокий профиль его безопасности и возможность использования у пациентов, рефрактерных к стандартной базисной терапии и ингибиторам фактора некроза опухоли . Представлены результаты клинических исследований по оценке эффективности и безопасности абатацепта при различных вариантах ревматоидного артрита у взрослых и ювенильного идиопатического артрита у детей. Раскрыты преимущества и перспективы использования препарата в детской ревматологии: возможность назначения в монотерапии, в т. ч. у пациентов с непереносимостью или недостаточной эффективностью метотрексата/ингибиторов фактора некроза опухоли . Авторами также приведены собственные данные о применении абатацепта у 8 детей с ювенильным идиопатическим артритом, проживающих в Республике Мордовия, в т. ч. составляющих группу риска по активации туберкулезной инфекции. 50% улучшения по педиатрическим критериям Американской коллегии ревматологов через 1 год наблюдения достигли 75% детей, половина из которых были рефрактерны к генно-инженерным биологическим препаратам.
Об авторах
Л. А. Балыкова
Медицинский институт Мордовского государственного университета им. Н.П. Огарёва, Саранск
Россия
Россия
Н. В. Ивянская
Детская республиканская клиническая больница, Саранск
Россия
Россия
А. В. Краснопольская
Медицинский институт Мордовского государственного университета им. Н.П. Огарёва, Саранск
Россия
Россия
П. А. Трупанова
Медицинский институт Мордовского государственного университета им. Н.П. Огарёва, Саранск
Россия
Россия
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Для цитирования:
Балыкова Л.А., Ивянская Н.В., Краснопольская А.В., Трупанова П.А. АБАТАЦЕПТ В ЛЕЧЕНИИ ЮВЕНИЛЬНОГО ИДИОПАТИЧЕСКОГО АРТРИТА: ДАННЫЕ МЕЖДУНАРОДНЫХ ИССЛЕДОВАНИЙ И ОПЫТ ИСПОЛЬЗОВАНИЯ В РЕСПУБЛИКЕ МОРДОВИЯ. Вопросы современной педиатрии. 2014;13(2):28-35. https://doi.org/10.15690/vsp.v13i2.970
For citation:
Balykova L.A., Ivyanskaya N.V., Krasnopol’skaya A.V., Trupanova P.A. ABATACEPT IN TREATMENT OF JUVENILE IDIOPATHIC ARTHRITIS: INTERNATIONAL DATA AND EXPERIENCE OF USAGE IN THE REPUBLIC OF MORDOVIA. Current Pediatrics. 2014;13(2):28-35. (In Russ.) https://doi.org/10.15690/vsp.v13i2.970
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