Периостин — биомаркер бронхиальной астмы
Аннотация
В основе патогенеза большинства случаев бронхиальной астмы (БА) лежит иммунное воспаление, регулируемое субпопуляцией CD4+ T-клеток 2-го типа. Однако не все механизмы хронического воспаления при БА изучены до конца. Относительно недавно установлено участие белка внеклеточного матрикса периостина в развитии эозинофильного воспаления и ремоделировании дыхательных путей при БА. Влияние периостина на развитие и течение БА подтверждается высокой экспрессией этого белка в эпителиальных клетках бронхов пациентов. В обзоре представлены современные данные о строении и синтезе периостина, связи периостина с развитием и течением БА, с функцией внешнего дыхания. Особое внимание уделено роли периостина при БА у детей.
Об авторе
Н. В. Шахова
Алтайский государственный медицинский университет; Сибирский государственный медицинский университет
Россия
Раскрытие интересов: отсутствие конфликта интересов, о котором необходимо сообщить
Россия
Шахова Наталья Викторовна - доцент кафедры пропедевтики детских болезней АГМУ, докторант кафедры факультетской педиатрии с курсом детских болезней лечебного факультета СГМУ, врач аллерголог-иммунолог.
656043, Барнаул, пр. Ленина, д. 40, тел.: +7 (385) 261-91-82
Раскрытие интересов: отсутствие конфликта интересов, о котором необходимо сообщить
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Для цитирования:
Шахова Н.В. Периостин — биомаркер бронхиальной астмы. Вопросы современной педиатрии. 2019;18(5):339-345. https://doi.org/10.15690/vsp.v18i5.2056
For citation:
Shakhova N.V. Periostin as a Biomarker of Bronchial Asthma. Current Pediatrics. 2019;18(5):339-345. (In Russ.) https://doi.org/10.15690/vsp.v18i5.2056
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