Периостин — биомаркер бронхиальной астмы
https://doi.org/10.15690/vsp.v18i5.2056
Аннотация
В основе патогенеза большинства случаев бронхиальной астмы (БА) лежит иммунное воспаление, регулируемое субпопуляцией CD4+ T-клеток 2-го типа. Однако не все механизмы хронического воспаления при БА изучены до конца. Относительно недавно установлено участие белка внеклеточного матрикса периостина в развитии эозинофильного воспаления и ремоделировании дыхательных путей при БА. Влияние периостина на развитие и течение БА подтверждается высокой экспрессией этого белка в эпителиальных клетках бронхов пациентов. В обзоре представлены современные данные о строении и синтезе периостина, связи периостина с развитием и течением БА, с функцией внешнего дыхания. Особое внимание уделено роли периостина при БА у детей.
Ключевые слова
дети,
бронхиальная астма,
периостин,
эозинофильное воспаление,
ремоделирование дыхательных путей,
функция внешнего дыхания
При поддержке: Не указан
Об авторе
Н. В. Шахова
Алтайский государственный медицинский университет; Сибирский государственный медицинский университет
Россия
Раскрытие интересов: отсутствие конфликта интересов, о котором необходимо сообщить
Россия
Шахова Наталья Викторовна - доцент кафедры пропедевтики детских болезней АГМУ, докторант кафедры факультетской педиатрии с курсом детских болезней лечебного факультета СГМУ, врач аллерголог-иммунолог.
656043, Барнаул, пр. Ленина, д. 40, тел.: +7 (385) 261-91-82
Раскрытие интересов: отсутствие конфликта интересов, о котором необходимо сообщить
Список литературы
1. Akids CA, Agache I. Global athlas of asthma. Zurich, European Academy of Allergy and Clinical Immunology; 2013. рр. 7-9.
2. Cezmi AI, Chivato AT, Hellings P et al. (ed.). EAACI WHITE PAPER on Research, Innovation and Quality Care. European Academy of Allergy and Clinical Immunology; 2018.
3. Global strategy for asthma management and prevention [updata 2019]. Global Initiative for Asthma; 2019. Available from: https://ginasthma.org/wp-content/uploads/2019/06/GINA-2019-main-report-June-2019-wms.pdf.
4. James A, Hedlin G. Biomarkers for the phenotyping and monitoring of asthma in children. Сигг Тгeat Options Allergy. 2016;3(4): 439-452. doi: 10.1007/s40521-016-0106-0.
5. Nuzzo PV, Buzzatti G, Ricci F, et al. Periostin: a novel prognostic and therapeutic target for genitourinary cancer? Clin Genitourin Сапсег. 2014;12(5):301-311. doi: 10.1016/j.clgc.2014.02.005.
6. Takayama G, Arima K, Kanaji T, et al. Periostin: a novel component of subepithelial fibrosis of bronchial asthma downstream of IL-4 and IL-13 signals. JAllergy Clin Immunol. 2006;118(1):98-104. doi: 10.1016/j.jaci.2006.02.046.
7. Соботюк Н.В, Гапоненко В.П., Бочанцев С.В., и др. Потенциальная роль сывороточного периостина в ранней диагностике бронхиальной астмы у детей // Вопросы современной педиатрии. — 2016. — Т. 15. — № 5. — С. 452-456. doi: 10.15690/vsp.v15i5.1619.
8. Takeshita S, Kikuno R, Tezuka K, Amann E. Osteoblast-specific factor 2: cloning of a putative bone adhesion protein with homology with the insect protein fasciclin I. Biochem J. 1993;294(1): 271-278. doi: 10.1042/bj2940271.
9. Hoersch S, Andrade-Navarro MA. Periostin shows increased evolutionary plasticity in its alternatively spliced region. BMC Evo Biol. 2010;28:10-30. doi: 10.1186/1471-2148-10-30.
10. Kudo А. Introductory review: periostin — gene and protein structure. Cell Mol Life Sci. 2017;74(23):4259-4268. doi: 10.1007/s00018-017-2643-5.
11. Huber O, Sumper M. Algal-CAMs: isoforms of a cell adhesion molecule in embryos of the alga Volvox with homology to Drosophila fasciclin I. EMBO J. 1994;13(18):4212-4222. doi: 10.1002/j.1460-2075.1994.tb06741.x.
12. Ulstrup JC, Jeansson S, Wiker HG, Harboe M. Relationship of secretion pattern and MPB70 homology with osteoblast-specific factor 2 to osteitis following Mycobacterium bovis BCG vaccination. Infect Immun. 1995;63(2):672-675.
13. Doliana R, Bot S, Bonaldo P, Colombatti A. EMI, a novel cysteine-rich domain of EMILINs and other extracellular proteins, interacts with the gC1q domains and participates in multimeriza-tion. FEBS Lett. 2000;484(2):164-168. doi: 10.1016/s0014-5793(00)02140-2.
14. Kii I, Nishiyama T, Kudo A. Periostin promotes secretion of fibronectin from the endoplasmic reticulum. Biochem Biophy Res Commun. 2016;470(4):888-893. doi: 10.1016/j.bbrc.2016.01.139.
15. Van Vliet AI, van Alderwegen IE, Baelde HJ, et al. Fibronectin accumulation in glomerulosclerotic lesions: self-assembly sites and the heparin II binding domain. Kidney Int. 2002;61(2):481-489. doi: 10.1046/j.1523-1755.2002.00159.x.
16. Conway SJ, Izuhara K, Kudo Y et al. The role of periostin in tissue remodeling across health and disease. Cell Mol Life Sci. 2014;71(7):1279-1288. doi: 10.1007/s00018-013-1494-y.
17. Rosselli-Murai LK, Almeida LO, Zagni C, et al. Periostin responds to mechanical stress and tension by activating the MTOR signaling pathway. PLoS One. 2013;8(12):e83580. doi: 10.1371/journal.pone.0083580.
18. Horiuchi K, Amizuka N, Takeshita S, et al. Identification and characterization of a novel protein, periostin with restricted expression to periosteum and periodontal ligament and increased expression by transforming growth factor p. J Bone Miner Res. 1999;14(7): 1239-1249. doi: 10.1359/jbmr.1999.14.7.1239.
19. Yuyama N, Davies DE, Akaiwa M, et al. Analysis of novel disease-related genes in bronchial asthma. Cytokine. 2002;19(6):287-296. doi: 10.1006/cyto.2002.1972.
20. Izuhara K, Arima K, Yasunaga S. IL-4 and IL-13: their pathological roles in allergic diseases and their potential in developing new therapies. Curr Drug Targets Inflamm Allergy. 2002;1(3):263-269. doi: 10.2174/1568010023344661.
21. Woodruff PG, Boushey HA, Dolganov GM, et al. Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids. Proc Natl Acad Sci U S A. 2007;104(40):15858-15863. doi: 10.1073/pnas.0707413104.
22. Uysal P Birtekocak F, Karul AB. The relationship between serum TARC, TSLP and POSTN levels and childhood atopic dermatitis. Clin Lab. 2017;63(7):1071-1077. doi: 10.7754/Clin.Lab.2017.161107.
23. Fujishima H, Okada N, Matsumoto K, et al. The usefulness of measuring tear periostin for the diagnosis and management of ocular allergic diseases. J Allergy Clin Immunol. 2016;138(2): 459-467:e2. doi: 10.1016/j.jaci.2015.11.039.
24. Politi E, Angelakopoulou A, Grapsa D, et al. Filaggrin and perios-tin expression is altered in eosinophilic esophagitis and normalized with treatment. J Pediatr Gastroenterol Nutr. 2017;65(1):47-52. doi: 10.1097/MPG.0000000000001419.
25. Sidhu SS, Yuan S, Innes AL, et al. Roles of epithelial cell-derived periostin in TGF-beta activation, collagen production, and collagen gel elasticity in asthma. Proc Natl Acad Sci U S A. 2010;107(32):14170-14175. doi: 10.1073/pnas.1009426107.
26. Shoda T, Futamura K, Kobayashi F, et al. Cell type-dependent effects of corticosteroid on periostin production by primary human tissue cells. Allergy. 2013;68(11):1467-1470. doi: 10.1111all.12240.
27. Takayama G, Arima K, Kanaji T, et al. Periostin: a novel component of subepithelial fibrosis of bronchial asthma downstream of IL-4 and IL-13 signals. J Allergy Clin Immunol. 2006;118(1):98-104. doi: 10.1016/j.jaci.2006.02.046.
28. Masuoka M, Shiraishi H, Ohta S, et al. Periostin promotes chronic allergic inflammation in response to Th2 cytokines. J Clin Invest. 2012;122(7):2590-2600. doi: 10.1172/JCI58978.
29. Makita K, Mikami Y, Matsuzaki H, et al. Mechanism of periostin production in human bronchial smooth muscle cells. Int Arch Allergy Immunol. 2018;175(1-2):26-35. doi: 10.1159/000485892.
30. Inoue Y, Izuhara K, Ohta S, et al. No increase in the serum periostin level is detected in elementary school-age children with allergic diseases. Allergol Int. 2015;64(3):289-290. doi: 10.1016/j.alit.2015.04.001.
31. Fujitani H, Kasuga S, Ishihara T, et al. Age-related changes in serum periostin level in allergic and non-allergic children. Allergol Int. 2019;68(2):285-286. doi: 10.1016/j.alit.2018.12.006.
32. Voehringer D, Reese TA, Huang X, et al. Type 2 immunity is controlled by IL-4/IL-13 expression in hematopoietic non-eosinophil cells of the innate immune system. J Exp Med. 2006;203: 1435-1446. doi: 10.1084/jem.20052448.
33. Fahy JV. Type 2 inflammation in asthma — present in most, absent in many. Nat Rev Immunol. 2015;15(1):57-65. doi: 10.1038/nri3786.
34. Agache IO. From phenotypes to endotypes to asthma treatment. Curr Opin Allergy Clin Immunol. 2013;13:249-256. doi: 10.1097/ACI.0b013e32836093dd.
35. Green RH, Brightling CE, Woltmann G, et al. Analysis of induced sputum in adults with asthma: identification of subgroup with isolated sputum neutrophilia and poor response to inhaled corticosteroids. Thorax. 2002;57(10):875-879. doi: 10.1136/thorax.57.10.875.
36. GINA Difficult-to-treat and severe asthma in adolescent and adult patient. Global Initiative for Asthma; 2019. Available from: https://ginasthma.org.
37. Dougherty RH, Sidhu SS, Raman K, et al. Accumulation of intraepithelial mast cells with a unique protease phenotype in TH2-high asthma. J Allergy Clin Immunol. 2010;125(5):1046-1053.e8. doi: 10.1016/j.jaci.2010.03.003.
38. Izuhara K, Conway SJ, Moore BB, et al. Roles of periostin in respiratory disorders. Am J Respir Crit Care Med. 2016;193(9): 949-956. doi: 10.1164/rccm.201510-2032PP.
39. Lopez-Guisa JM, Powers C, File D, et al. Airway epithelial cells from asthmatic children differentially express proremodeling factors. J Allergy Clin Immunol. 2012;129(4):990-997. e996. doi: 10.1016/j.jaci.2011.11.035.
40. Peters MC, Mekonnen ZK, Yuan S, et al. Measures of gene expression in sputum cells can identify T2-high and T2-low subtypes of asthma. J Allergy Clin Immunol. 2014;133(4):388-394. doi: 10.1016/j.jaci.2013.07.036.
41. Johansson MW, Annis DS, Mosher DF. aMb2 integrin-mediated adhesion and motility of IL-5 stimulated eosinophils on periostin. 2013;48(4):503-510. doi: 10.1165/rcmb.2012-0150OC.
42. Blanchard C, Mingler MK, McBride M, et al. Periostin facilitates eosinophil tissue infiltration in allergic lung and esophageal responses. Mucosal Immunol. 2008;1(4):289-296. doi: 10.1038/mi.2008.15.
43. Jia G, Erickson RW, Choy DF, et al. Bronchoscopic exploratory research study of Biomarkers in Corticosteroid-Refractory Asthma (BOBCAT) Study Group. Periostin is a systemic biomarker of eosinophilic airway inflammation in asthmatic patients. J Allergy Clin Immunol. 2012;130:647-654.e10. doi: 10.1016/j.jaci.2012.06.025.
44. Wagener AH, de Nijs SB, Lutter R, et al. External validation of blood eosinophils, FE(NO) and serum periostin as surrogates for sputum eosinophils in asthma. Thorax. 2015;70(2):115-120. doi: 10.1136/thoraxjnl-2014-205634.
45. O'Dwyer DN, Moore BB. Role of periostin in lung fibrosis and airway remodeling. Cell Mol Life Sci. 2017;74(23):4305-4314. doi: 10.1007/s00018-017-2649-z.
46. Kudo A. Periostin in fibrillogenesis for tissue regeneration: periostin actions inside and outside the cell. Cell Mol Life Sci. 2011;68(19):3201-3207. doi: 10.1007/s00018-011-0784-5.
47. Gillan L, Matei D, Fishman DA, et al. Periostin secreted by epithelial ovarian carcinoma is a ligand for alpha (V) beta (3) and alpha (V) beta (5) integrins and promotes cell motility. Cancer Res. 2002;62(18):5358-5364.
48. Ruan K, Bao S, Ouyang G. The multifaceted role of periostin in tumorigenesis. Cell Mol Life Sci. 2009;66(14):2219-2230. doi: 10.1007/s00018-009-0013-7.
49. Kanemitsu Y, Ito I, Niimi A, et al. Osteopontin and periostin associate with a 20-year decline of pulmonary function in asthmatics. Am J Respir Crit Care Med. 2014;190(4):472-474. doi: 10.1164/rccm.201403-0562LE.
50. Hoshino M, Ohtawa J, Akitsu K. Association of airway wall thickness with serum periostinum in steroid-naive asthma. Allergy Asthma Proc. 2016;37(3):225-230. doi: 10.2500/aap.2016.37.3945.
51. Izuhara K, Arima K, Ohta S, et al. Periostin in allergic inflammation. Allergol Int. 2014;63(2):143-151. doi: 10.2332/allergolint.13-RAI-0663.
52. James A, Janson C, Malinovschi A, et al. Serum periostin relates to type-2 inflammation and lung function in asthma: data from the large population-based cohort Swedish GA(2)LEN. Allergy. 2017;72(11):1753-1760. doi: 10.1111/all.13181.
53. Kanemitsu Y, Matsumoto H, Izuhara K, et al. Increased periostin associates with greater airflow limitation in patients receiving inhaled corticosteroids. J Allergy Clin Immunol. 2013;132(2): 305-312. doi: 10.1016/j.jaci.2013.04.050.
54. Matsusaka M, Kabata H, Fukunaga K, et al. Phenotype of asthma related with high serum periostin levels. Allergol Int. 2015;64(2):175-180. doi: 10.1016/j.alit.2014.07.003.
55. Solanki B, Prakash A, Rehan HS, Gupta LK. Effect of inhaled corticosteroids on serum periostin levels in adult patients with mild-moderate asthma. Allergy Asthma Proc. 2019;40(1):32-34. doi: 10.2500/aap.2019.40.4179.
56. Song JS, You JS, Jeong SI, et al. Serum periostin levels correlate with airway hyper-responsiveness to methacholine and mannitol in children with asthma. Allergy. 2015;70(6):674-681. doi: 10.1111/all.12599.
57. Inoue T, Akashi K, Watanabe M, et al. Periostin as a biomarker for the diagnosis of pediatric asthma. Pediatr Allergy Immunol. 2016;27(5):521-526. doi: 10.1111/pai.12575.12.
58. Cho JH, Kim K, Yoon JW, et al. Serum levels of periostin and exercise-induced bronchoconstriction in asthmatic children. World Allergy Organ J. 2019;(12):1-7. doi: 10.1016/j.waojou.2018.11.004.
59. El Basha NR, Osman HM, Abdelaal AA, et al. Increased expression of serum periostin and YKL40 in children with severe asthma and asthma exacerbation. J Investig Med. 2018;66(8):1102-1108. doi: 10.1136/jim-2017-000680.
60. Масальский С.С., Калмыкова А.С., Уханова О.П. Комплексная оценка сывороточного периостина — нового маркера аллергического воспаления при неконтролируемой бронхиальной астме у детей // Российский аллергологический журнал. — 2018. — Т. 15. — № S1-2. — С. 55-57.
61. Шахова Н.В., Камалтынова Е.М., Кашинская Т.С. Диагностика бронхиальной астмы у детей в возрасте 3-6 лет с применением сывороточного периостина и суррогатных маркеров эозинофильного воспаления (эозинофилы крови и уровень общего IgE): одномоментное исследование // Вопросы современной педиатрии. — 2019. — Т. 18. — № 2. — С. 118-124. doi: 10.15690/vsp.v18i2.2014.
62. Simpson JL, Yang IA, Upham JW, et al. Periostin levels and eosinophilic inflammation in poorly-controlled asthma. BMC Pulm Med. 2016;16(1):67. doi: 10.1186/s12890-016-0230-4.
63. Takahashi K, Meguro K, Kawashima H, et al. Serum periostin levels serve as a biomarker for both eosinophilic airway inflammation and fixed airflow limitation in well-controlled asthmatics. J Asthma. 2019;56(3): 236-243. doi: 10.1080/02770903.2018.1455855.
64. Bobolea I, Barranco P, Del Pozo V, et al. Sputum periostin in patients with different severe asthma phenotypes. Allergy. 2015;70(5):540-546. doi: 10.1111/all.12580.
65. Johansson MW, Evans MD, Crisafi GM, et al. Serum periostin is associated with type 2 immunity in severe asthma. J Allergy Clin Immunol. 2016;137(6):1904-1907.e2. doi: 10.1016/j.jaci.2015.12.1346.
66. Pavlidis S, Takahashi K, Ng Kee Kwong F, et al. T2-high in severe asthma related to blood eosinophil, exhaled nitric oxide and serum periostin. Eur Respir J. 2019;53(1). pii: 1800938. doi: 10.1183/13993003.00938-2018.
67. Habernau Mena A, Del Pozo Abejon V, Rodriguez Vidigal FF, Bobadilla Gonzalez P. Role of periostin in uncontrolled asthma in children (DADO study). J Investig Allergol Clin Immunol. 2017;27(5):291-298. doi: 10.18176/jiaci.0144.
68. Licari A, Brambilla I, Sacchi L, et al. Periostin, type 2 biomarker, is not associated with asthma control grade in asthmatic allergic children. Respir Med. 2019;151:118-120. doi: 10.1016/j.rmed.2019.04.010.
69. Масальский С.С. Диагностическая значимость уровней сывороточного периостина и витамина D при бронхиальной астме у детей школьного возраста: Автореф. дис. ... канд. мед. наук. — Ставрополь, 2018. — 23 с. Доступно по: https://search.rsl.ru/ru/record/01008719030. Ссылка активна на 15.04.2019.
70. Wardzynska A, Makowska JS, Pawelczyk M, et al. Periostin in exhaled breath condensate and in serum of asthmatic patients: relationship to upper and lower airway disease. Allergy Asthma Immunol Res. 2017;9(2):126-132. doi: 10.4168/aair.2017.9.2.126.
71. Lee Y, Lee JH, Yang EM, et al. Serum levels of eosinophilderived neurotoxin: a biomarker for asthma severity in adult asthmatics. Allergy Asthma Immunol Res. 2019;11(3):394-405. doi: 10.4168/aair.2019.11.3.394.
72. Yasuda M, Harada N, Harada S, et al. Characterization of tenascin-C as a novel biomarker for asthma: utility of tenascin-C in combination with periostin or immunoglobulin E. Allergy Asthma Clin Immunol. 2018;14:72. doi: 10.1186/s13223-018-0300-7.
73. Carpagnano GE, Scioscia G, Lacedonia D, et al. Looking for airways periostin in severe asthma: could be useful for clustering type 2 endotype? Chest. 2018;154(5):1083-1090. doi: 10.1016/j.chest.2018.08.1032.
74. Масальский С.С., Калмыкова А.С., Уханова О.П., и др. Использование сывороточного периостина в качестве маркера обострений астмы у детей // Аллергология и иммунология в педиатрии. — 2018. — № 4. — С. 37-48.
75. Scichilone N, Crimi C, Benfante A, et al. Higher serum levels of periostin and the risk of exacerbations in moderate asthmatics. Asthma Res Pract. 2016;2:1. doi 10.1186/s40733-015-0019-x.
76. Bentley JK, Chen Q, Hong JY, et al. Periostin is required for maximal airways inflammation and hyperresponsiveness in mice. J Allergy Clin Immunol. 2014;134(6):1433-1442. doi: 10.1016/j.jaci.2014.05.029.
77. Patelis A, Alving K, Middelveld R, et al. IgE sensitization to food allergen and airborn allergens in relation to biomarkers of type 2 inflammation in asthma. Clin Exp Allergy. 2018;48(9):1147-1154. doi: 10.1111/cea.13165.
78. Kanemitsu Y, Matsumoto H, Izuhara K, et al. Increased periostin associates with greater airflow limitation in patients receiving inhaled corticosteroids. J Allergy Clin Immunol. 2013;132(2): 305-312. doi: 10.1016/j.jaci.2013.04.050
79. Mansur AH, Srivastava S, Sahal A. Disconnect of type 2 biomarkers in severe asthma' dominated by FeNo as a predictor of exacerbations and periostin as predictor of reduced lung function. Respir Med. 2018;143:31-38. doi: 10.1016/j.rmed.2018.08.005.
80. Fingleton J, Braithwaite I, Travers J, et al.; NZRHS Study Group. Serum periostin in obstructive airways disease. Eur Respir J. 2016;47(5):1383-1391. doi: 10.1183/13993003.01384-2015.
Рецензия
Для цитирования:
Шахова Н.В. Периостин — биомаркер бронхиальной астмы. Вопросы современной педиатрии. 2019;18(5):339-345. https://doi.org/10.15690/vsp.v18i5.2056
For citation:
Shakhova N.V. Periostin as a Biomarker of Bronchial Asthma. Current Pediatrics. 2019;18(5):339-345. (In Russ.) https://doi.org/10.15690/vsp.v18i5.2056
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