STUDY OF THE ASSOCIATION OF POLYMORPHOUS MARKERS FOR IL1 FAMILY GENES (IL1B AND ILRA) WITH CLINICAL VARIANTS OF PYELONEPHRITIS
https://doi.org/10.15690/vsp.v13i1.912
Abstract
Aim: to study the distribution of alleles and genotypes of polymorphic markers for immunoregulatory cytokines in the development of chronic pyelonephritis and its clinical variants. Patients and Methods: in this study we analyzed a sample of 99 patients with chronic pyelonephritis. The average age of the patients was 8,01±3,26 (3,00–15,00) years. The study of gene polymorphisms was performed using PDRF analysis. For PCR were used primers structures and genotyping conditions described in the literature. Results: the analysis of associations of 2 loci in the genes of cytokines with different complex phenotypes of chronic pyelonephritis demonstrated that A2 allele and genotype A2A2 of IL1RN*VNTR polymorphism is associated with chronic pyelonephritis, vesicoureteral reflux, secondary pyelonephritis, renal dysfunction, infection with Escherichia coli and Klebsiella. Genotype A2A2 of gene IL1RN*VNTR and allele A2 of gene IL1RN*VNTR are associated with impaired renal function OR =3,07 (p =0,001). The highest risk of chronic renal failure development is associated with A1A2 genotype (OR =22,94; p=0,001). Conclusions: the discovered associations require further confirmation on larger samples and various ethnicities.
About the Authors
E. I. Kondrat'eva
Kuban State Medical University, Krasnodar
Medical Genetics Research Centre of RAMS, Moscow
Russian Federation
Russian Federation
A. A. Terent'eva
Siberian State Medical University, Tomsk
Russian Federation
Russian Federation
N. V. Tarasenko
Research Institute of Medical Genetics, Siberian Branch of RAMS, Tomsk
Russian Federation
Russian Federation
E. V. Loshkova
Siberian State Medical University, Tomsk
Russian Federation
Russian Federation
A. I. Tlif
Kuban State Medical University, Krasnodar
Russian Federation
Russian Federation
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Review
For citations:
Kondrat'eva E.I., Terent'eva A.A., Tarasenko N.V., Loshkova E.V., Tlif A.I. STUDY OF THE ASSOCIATION OF POLYMORPHOUS MARKERS FOR IL1 FAMILY GENES (IL1B AND ILRA) WITH CLINICAL VARIANTS OF PYELONEPHRITIS. Current Pediatrics. 2014;13(1):60-64. (In Russ.) https://doi.org/10.15690/vsp.v13i1.912
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