AB0 Hemolytic Disease of the Newborn Development in the Child with АВ (IV) Blood Group from the Mother with 0 (I) Blood Group: Clinical Case

Background. Hemolytic disease of the newborn due to AB0 incompatibility typically develops when mother has 0 (I) blood group and prenatal child has А (II) or B (III). Mother’s antibodies аand рhave immune interaction with the child’s antigens A or B in such situation. It became possible for woman with 0 (I) group to carry of the child with AB (IV) group due to the use of donor ovum for in vitro fertilization. Naturally it is impossible. Clinical Case Description. Hemolytic disease of the newborn development in the child with АВ(IV) Blood Group from the Mother with 0 (I) Blood Group is demonstrated. It was the child of the second pregnancy resulting from in vitro fertilization of donor ovum with intracytoplasmic sperm injection and further tubal embryo transfer. The disease was manifested with icteric and anemia syndromes. Hyperbilirubinemia presented from birth, maximum level was on the 5th day of life. The treatment included phototherapy and immunoglobulin intravenous injections. The child's condition was stabilized by the 6th day. Conclusion. The hemolytic disease of the newborn development is possible when the woman with 0 (I) blood group is carrying the fetus with AB (IV) group especially when we are using donor ovum for in vitro fertilization without taking into account the blood group of the donor. It must be considered during preimplantation genetic testing, selection and tubal embryo transfer.

1. Antonov A.G., Degtyarev D.N., Narogan M.V., et al. Hemolytic disease of the fetus and newborn. Clinical practice guideline. Neonatologiia. 2018;6(2):131-142. (In Russ).

2. Volodin NN. Neonatologiia. Natsional'noe rukovodstvo. Kratkoe izdanie. Moscow: GEOTAR-Media; 2013. 896 p. (In Russ).]

3. Shabalov NP. Neonatologiia: uchebnoe posobie dlia studentov, obuchaiushchikhsia po spetsial'nosti 040200 — Pediatriia. 5th ed. revised and updated. Moscow: MEDpress-inform; 2009. (In Russ).]

4. Gomella TL. Neonatology: management, procedures, on-call problems, diseases, and drugs. Medical Publishing Division; 2013. 1113 p.

5. Mitra R, Mishra N, Rath G.P Blood groups systems. Indian J Anaesthesia. 2014;58(5):524-528. doi: 10.4103/0019-5049.144645.

6. Klein H, Anstee D, Mollison P. Blood transfusion in clinical medicine. London: Blackwell Publishing; 2005. 891 p.

7. Shautsukova LZ. AB0 Blood group system. Genetics, biochemistry, physiology. Izvestiia vysshikh ucheb-nykh zavedenii. Severo-Kavkazskii region. Estestvennye nauki. 2010;(2):131-133 (InRuss).

8. Alfaro JA, Zhenq RB, Person M, et al. ABO (H) blood group A and B glycosyltransferases recognize substrate via specific conformational changes. J Biol Chem. 2008;283(15):10097-10108. doi: 10.1074/jbc.M708669200.

9. Pokrovskiy VM, Korot'ko GF. Fiziologiia cheloveka. Moscow: Meditsina; 2003. 656 р. (In Russ).

10. Drannik GN. Klinicheskaia immunologiia i allergologiia. Moscow: Med. inform. agentstvo; 2003. 603 р. (In Russ).

11. Mineeva NV. Gruppy krovi cheloveka (osnovy immunologii). Saint Petersburg; 2010. 360 р. (In Russ).

12. Rooz R, Gentsel'-Borovicheni O, Prokitte G. Neonatologiia. Prakticheskie rekomendatsii. Transl. from German. Moscow: Med. Lit.; 2010. 592 р. (In Russ).

13. Abdrakhmanova LR. Izoimmunizatsiia pri lechenii beremennykh vnutrivennymi infuziiami immunoglobulinov. Vozmozhno li eto? Practical medicine. 2007;(1):21-22. (In Russ).

14. Butina EV, Zaitseva GA. Allosensibilizatsiia k antigenam eritrotsitov u zhenshchin reproduktivnogo vozrasta. Viatskii meditsinskii vestnik. 2016;(2):32-35. (In Russ).

15. Kurzina EA, PetrenkoYuV, Ivanov DO. Dicators of clinical blood newborns in the period of adaptation. Byulleten’ Federal’nogo tsentra serdtsa, krovi i endokrinologii im. V.A. Almazova. 2012;(1):56-60. (In Russ).

16. Petrenko YuV, Ivanov DO, Cherednikova ES, Myznikova IV. Analysis of the hemolytic disease of newborn with conflicts AB0-system. Vestnik Rossiiskoi Voenno-meditsinskoiakademii. 2012;(4):67-70. (In Russ).

17. Shurin SB. Hematologic problems in the fetus and neonate. In: Fanaroff A, Martin R, ed. Neonatal-perinatal medicine disease of the fetus and infants. 5th ed. Chicago: Mosby-Year book; 1992.

18. Keir AK, Dunn M, Callum J. Should intravenous immunoglobulin beused in infants with isoimmune haemolytic disease due to AB0 incompatibility? J Paediatr Child Health. 2013;49:1072-1078. doi: 10.1111/jpc.12440.

19. Hansen AR, Eichenwald EC, Stark AR, Martin CR. Cloherty and stark's manual of neonatal care. 8th ed. Wolters Kluwer; 2016. 1124