Ювенильная локализованная склеродермия. Вопросы лечения
https://doi.org/10.15690/vsp.v19i3.2119
Аннотация
Ювенильная локализованная склеродермия (ЮЛС) это группа заболеваний детского возраста, основное проявление которых — поражение кожи и подкожных структур, как правило, без органного вовлечения. В развитии ЮЛС выделяют активную (воспалительную) и фибротическую фазы. Терапия ЮЛС в активную фазу, когда проявления со стороны кожи носят обратимый характер, намного эффективнее. Тактика лечения определяется площадью и глубиной очагов кожного поражения, появлением и распространением новых очагов, наличием внекожных признаков болезни. Основой терапии ЮЛС служат топические и системные иммуносупрессанты. Антибиотикотерапия не показана. Для оценки эффективности терапии рекомендовано использовать клинические шкалы (LoSCAT), ультразвуковое исследование, термо- и магнитно-резонансную томографию.
Ключевые слова
ювенильная локализованная склеродермия,
морфея,
линейная склеродермия,
топические глюкокортикостероиды,
такролимус,
метотрексат,
микофенолата мофетил,
генно-инженерные биологические препараты
При поддержке: Работа поддержана грантом РФФИ № 18-515-57001.
Об авторах
Р. К. Раупов
Санкт-Петербургский государственный педиатрический медицинский университет
Россия
194100, Санкт-Петербург, ул. Литовская, д. 2
Раскрытие интересов: Р. К. Раупов подтвердил отсутствие конфликта интересов, о котором необходимо сообщить.
Россия
194100, Санкт-Петербург, ул. Литовская, д. 2
Раскрытие интересов: Р. К. Раупов подтвердил отсутствие конфликта интересов, о котором необходимо сообщить.
М. М. Костик
Санкт-Петербургский государственный педиатрический медицинский университет
Россия
Раскрытие интересов: М. М. Костик — получение гонораров за чтение лекций от компаний «Пфайзер», «Новартис», «Cанофи».
Россия
Костик Михаил Михайлович, доктор медицинских наук, профессор кафедры госпитальной педиатрии
194100, Санкт-Петербург, ул. Литовская, д. 2
Раскрытие интересов: М. М. Костик — получение гонораров за чтение лекций от компаний «Пфайзер», «Новартис», «Cанофи».
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Рецензия
Для цитирования:
Раупов Р.К., Костик М.М. Ювенильная локализованная склеродермия. Вопросы лечения. Вопросы современной педиатрии. 2020;19(3):228-234. https://doi.org/10.15690/vsp.v19i3.2119
For citation:
Raupov R.K., Kostik M.M. Juvenile Localized Scleroderma. Questions of Treatment. Current Pediatrics. 2020;19(3):228-234. (In Russ.) https://doi.org/10.15690/vsp.v19i3.2119
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