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Modern Aspects of Celiac Disease Diagnosis in Children

https://doi.org/10.15690/vsp.v19i5.2217

Abstract

Celiac disease is an immune-mediated systemic disorder caused by gluten in people with genetic predisposition. Celiac disease is characterized by wide range of clinical manifestations (both gastroenterological and extraintestinal), that can complicate the diagnosis. Thus, celiac disease often remains undiagnosed. ESPGHAN has published updated clinical guidelines with adjusted coeliac disease diagnosis algorithms in 2020. It is proposed to determine antibodies to tissue transglutaminase (TGA-IgA) and total IgA within normal content of gluten-containing products in the diet on the first stage of children screening. The diagnosis of celiac disease can be established without small intestine biopsy in case of increased levels of TGA-IgA ≥ 10 of upper limit of normal and presence of antibodies to endomysium (EMA-IgA) in secondary serum. In such cases, ESPGHAN does not recommend any additional genetic testing to confirm celiac disease as it does not increase the reliability of the diagnosis. Antigen tests on class G or A antibodies against native gliadin are not specific and are not recommended for use in the diagnosis of celiac disease.

About the Authors

Aelita A. Kamalova
Kazan State Medical University
Russian Federation
Kazan
Disclosure of interest:

Aelita A. Kamalova — receiving fees for lecturing from “PROGRESS”



Daria O. Timofeeva
Kazan State Medical University
Russian Federation
Kazan
Disclosure of interest:

Аuthors confirmed the absence of a reportable conflict of interests



Almazia R. Shakirova
Children’s Republican Clinical Hospital
Russian Federation
Kazan
Disclosure of interest:

Аuthors confirmed the absence of a reportable conflict of interests



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Review

For citations:


Kamalova A.A., Timofeeva D.O., Shakirova A.R. Modern Aspects of Celiac Disease Diagnosis in Children. Current Pediatrics. 2020;19(5):371-378. (In Russ.) https://doi.org/10.15690/vsp.v19i5.2217

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