Clinical Case of Sarcoidosis as a Rare Cause of Lymphadenopathy in Preschool Child
Elena Y. Khorosheva,
Elena B. Khramova,
Natalya E. Gorohova,
Natalya A. Mashkina,
Nikolay V. Kozlov,
Ksenia P. Kuzmicheva https://doi.org/10.15690/vsp.v21i2.2393
Abstract
Background. Assignment of causes of generalized lymphadenopathy causes as a symptom of various diseases is still challenging. In case of no infectious causes, the morphological study is necessary also to exclude sarcoidosis, rare for young children immunemediated systemic disease with intermediate prognosis.
Clinical case description. 4 years girl was diagnosed sarcoidosis with typical lesions of intrathoracic lymph nodes and lungs along with signs of generalized lymphadenopathy. Molecular genetic testing has revealed pathogenic variant in the TNFRSF13B gene that was previously described in adult patients with general variable immunodeficiency and pulmonary sarcoidosis. Catamnestic follow-up data on this patient are presented for 3 years. There were no relapses without immunosuppressive therapy.
Conclusion. Sarcoidosis was described as the cause of generalized lymphadenopathy in preschool child. Following the federal guidelines has helped to adjust diagnosis tactics, to establish diagnosis, and to choose treatment.
Supporting agencies: Not specified.
About the Authors
Elena Y. Khorosheva
Tyumen State Medical University; Regional Clinical Hospital № 1
Russian Federation
Disclosure of interest:
Russian Federation
Tyumen
Disclosure of interest:
Not declared.
Elena B. Khramova
Tyumen State Medical University
Russian Federation
Disclosure of interest:
Russian Federation
Tyumen
Disclosure of interest:
Not declared.
Natalya E. Gorohova
Regional Clinical Hospital № 1
Russian Federation
Disclosure of interest:
Russian Federation
Tyumen
Disclosure of interest:
Not declared.
Natalya A. Mashkina
Regional Clinical Hospital № 1
Russian Federation
Disclosure of interest:
Russian Federation
Tyumen
Disclosure of interest:
Not declared.
Nikolay V. Kozlov
Regional Clinical Phthisiopulmonological Center
Russian Federation
Disclosure of interest:
Russian Federation
Tyumen
Disclosure of interest:
Not declared.
Ksenia P. Kuzmicheva
Tyumen State Medical University; Regional Clinical Hospital № 1
Russian Federation
Disclosure of interest:
Russian Federation
Tyumen
Disclosure of interest:
Not declared.
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For citations:
Khorosheva E.Y., Khramova E.B., Gorohova N.E., Mashkina N.A., Kozlov N.V., Kuzmicheva K.P. Clinical Case of Sarcoidosis as a Rare Cause of Lymphadenopathy in Preschool Child. Current Pediatrics. 2022;21(2):118-124. (In Russ.) https://doi.org/10.15690/vsp.v21i2.2393
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