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Abnormal Uterine Bleeding in Adolescence Burdened with Severe Anemia: Clinical Case

https://doi.org/10.15690/vsp.v22i4.2612

Abstract

Background. Abnormal uterine bleeding (AUB) in adolescence is one of the urgent problems of medicine nowadays. It is on the 2nd place among all the reasons for hospitalization in gynecological departments, and its incidence among girls during puberty is 50%. Clinical case description. This is the clinical case of 15-year-old girl admitted to the gynecology department with complaints   on long-lasting bloody vaginal discharge, fatigue, dizziness. The diagnosis of «abnormal uterine bleeding in adolescence» burdened with iron deficiency anemia (IDA) was established according to laboratory and instrumental examinations. The patient underwent RBC-transfusion with specific buffy coat and was administered with hormonal hemostatic and anti-anemic therapy. Conclusion. We can conclude (with reference to this observation and the reviewed literature) not only that IDA is one of the most common complications of AUB in adolescence, but also what management should be used in such clinical cases.

About the Authors

Leila V. Adamyan
Moscow State University of Medicine and Dentistry named after A.I. Evdokimov; National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov
Russian Federation

Moscow


Disclosure of interest:

Нет



Elena V. Sibirskaya
Moscow State University of Medicine and Dentistry named after A.I. Evdokimov; Russian Children’s Clinical Hospital, Pirogov Russian National Research Medical University
Russian Federation

Moscow


Disclosure of interest:

Нет



Irina V. Karachentsova
Russian Children’s Clinical Hospital, Pirogov Russian National Research Medical University
Russian Federation

Moscow


Disclosure of interest:

Нет



Laura G. Pivazyan
National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov
Russian Federation

Moscow


Disclosure of interest:

Нет



Maria A. Loshkareva
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Moscow


Disclosure of interest:

Нет



Yuliya A. Kirillova
Russian Children’s Clinical Hospital, Pirogov Russian National Research Medical University
Russian Federation

Moscow


Disclosure of interest:

Нет



Sabina K. Murvatova
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Moscow


Disclosure of interest:

Нет



Kamila K. Murvatova
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Moscow


Disclosure of interest:

None



References

1. Adamyan LV, Sibirskaia EV, Koltunov IE, et al. Abnormal uterine bleeding in puberty: diagnosis and treatment. Russian Journal of Human Reproduction. 2016;22(6):89–97. (In Russ). doi: https://doi.org/10.17116/repro201622689-97

2. Deligeoroglou E, Karountzos V, Creatsas G. Abnormal uterine bleeding and dysfunctional uterine bleeding in pediatric and adolescent gynecology. Gynecol Endocrinol. 2013;29(1):74–78. doi: https://doi.org/10.3109/09513590.2012.705384

3. Munro MG. Practical aspects of the two FIGO systems for management of abnormal uterine bleeding in the reproductive years. Best Pract Res Clin Obstet Gynaecol. 2017;40:3–22. doi: https://doi.org/10.1016/j.bpobgyn.2016.09.011

4. Clinical guidelines (project). Abnormal uterine bleeding during puberty. Reproduktivnoe zdorov’e detey i podrostkov = Pediatric and Adolescent Reproductive Health. 2021;17(3):5–30. (In Russ). doi: https://doi.org/10.33029/1816-2134-2021-17-3-5-30

5. Sibirskaya EV, Adamyan LV, Loginova ON, et al. Abnormal uterine bleeding in adolescent (literature review). Russian Journal of Human Reproduction. 2015;21(5):74–79. (In Russ). doi: https://doi.org/10.17116/repro201521574-79

6. Dobrokhotova YuE, Karanasheva AKh. Abnormal uterine bleeding of the reproductive and premenopausal period: modern algorithms for examination and treatment. Topical Issues of Women’s Health. 2022;(1):8–12. (In Russ). doi: https://doi.org/10.46393/2713122X_2022_1_8

7. Lebduska E, Beshear D, Spataro BM. Abnormal Uterine Bleeding. Med Clin North Am. 2023;107(2):235–246. doi: https://doi.org/10.1016/j.mcna.2022.10.014

8. Mishina AI, Kazakova AV, Uvarova EV. Risk factors for abnormal uterine bleeding in pubertal girls, prognosis and prevention. Reproduktivnoe zdorov’e detey i podrostkov = Pediatric and Adolescent Reproductive Health. 2022;18(1):47–55. (In Russ). doi: https://www.doi.org/10.33029/1816-2134-2021-17-4-47-55

9. Detskaya ginekologiya: Book of reference. Markin BB, Yakovleva EYu, contributors. Kiev: Znannya; 2004. pp. 173–177. (Biblioteka praktikuyushchego vracha). (In Russ).

10. Dikke GB. Therapeutic tactics in abnormal uterine bleeding without anatomical substrate. Meditsinskiy sovet = Medical Council. 2018;(21):168–172. (In Russ). doi: https://doi.org/10.21518/2079-701X-2018-21-168-172

11. Sibirskaya ЕV, Pivazyan LG. Hormonal therapy for management of abnormal uterine bleeding in women of late reproductive age. Gynecology, Obstetrics and Perinatology. 2020;19(2):129–135. (In Russ). doi: https://doi.org/10.20953/1726-1678-2020-2-129-135

12. Mirza FG, Abdul-Kadir R, Breymann C, et al. Impact and management of iron deficiency and iron deficiency anemia in women’s health. Expert Rev Hematol. 2018;11(9):727–736. doi: https://doi.org/10.1080/17474086.2018.1502081

13. Selikhova MS, Zvereva ES. Abnormal uterine bleeding in girls: tips and tools. Russian Journal of Woman and Child Health. 2019;2(4):351–354. doi: https://doi.org/10.32364/2618-8430-2019-2-4-351-354

14. Achanna KS, Nanda J. Evaluation and management of abnormal uterine bleeding. Med J Malaysia. 2022;77(3):374–383.

15. DeLoughery TG. Iron Deficiency Anemia. Med Clin North Am. 2017; 101(2):319–332. doi: https://doi.org/10.1016/j.mcna.2016.09.004

16. Vasileva E, Aslanyan K, Piskunova S. Iron deficiency anemia in children: the modern view of hematologist. Glavnyi Vrach Uga Russia. 2017;(3): 8–10. (In Russ).

17. Bogdanov AN, Mazurov VI. Iron Deficiency Anemia in the XXI Century. Herald of the Northwestern State Medical University named after I.I. Mechnikov. 2016;8(4):106–112. (In Russ).

18. Zhorova VE, Khilkevich EG. Incidence and prevalence of iron deficiency anaemia. Meditsinskiy sovet = Medical Council. 2018;(13):78–81. (In Russ.) doi: https://doi.org/10.21518/2079-701X-2018-13-78-81

19. Baranov II, Salnikova IA, Nesterova LA. Clinical practice guidelines for the diagnosis and treatment of iron deficiency: the view from 2022. Akusherstvo i ginekologiya: novosti, mneniya, obuchenie = Obstetrics and Gynecology: News, Opinions, Training. 2022;10(2):56–64. (In Russ). doi: https://doi.org/10.33029/2303-9698-2022-10-2-56-64

20. Camaschella C. Iron defi ciency. Blood. 2019;133:30–39. doi: https://doi.org/10.1182/blood2018-05-815944

21. Dobrokhotova YuE, Khlynova SA. Correction of Iron Deficiency Anemia in Gynecological Patients. Lechebnoe delo. 2017;(3):31–36. (In Russ).

22. Uvarova EV. Abnormal uterine bleeding in puberty. Pediatric and Adolescent Reproductive Health. 2018;(1):64–91. (In Russ).

23. Chernuha GE, Ilina LM, Ivanov IA. Abnormal uterine bleeding: we diagnose and choose treatment. Gynecology. 2018;20(4):4–8. (In Russ). doi: https://doi.org/10.26442/2079-5696_2018.4.4-8

24. Elmaoğulları S, Aycan Z. Abnormal Uterine Bleeding in Adolescents. J Clin Res Pediatr Endocrinol. 2018;10(3):191–197. doi: https://doi.org/10.4274/jcrpe.0014

25. Ramalho I, Leite H, Águas F. Abnormal Uterine Bleeding in Adolescents: A Multidisciplinary Approach. Acta Med Port. 2021; 34(4):291–297. doi: https://doi.org/10.20344/amp.12829

26. Wang Y, Zhao L, Feng X. Two-Pronged Treatment of Hemoperitoneum and Abnormal Uterine Bleeding in an Adolescent Girl With Congenital Fibrinogen Deficiency. Front Med (Lausanne). 2020;7:181. doi: https://doi.org/10.3389/fmed.2020.00181

27. Kanbur NO, Derman O, Aksu T. Menorrhagia at menarche: a case report. Int J Adolesc Med Health. 2003;15(2):161–164. doi: https://doi.org/10.1515/ijamh.2003.15.2.161

28. Cooke AG, McCavit TL, Buchanan GR. Iron Deficiency Anemia in Adolescents Who Present with Heavy Menstrual Bleeding. J Pediatr Adolesc Gynecol. 2017;30(2):247–250. doi: https://doi.org/10.1016/j.jpag.2016.10.010

29. Sibirskaya EV, Adamyan LV, Yatsyk SP, et al. Abnormal uterine bleeding in adolescents — endocrine profile condition. Voprosy sovremennoi pediatrii — Current Pediatrics. 2014;13(4):136–139. (In Russ). doi: https://doi.org/10.15690/vsp.v13i4.1098

30. Adamyan LV, Petryaykina EE, Sibirskaya EV, et al. Abnormal uterine bleeding during puberty in adolescent girls: the management, diagnosis and treatment. Russian Journal of Human Reproduction. 2019;25(3):99–103. (In Russ). doi: https://doi.org/10.17116/repro20192503199

31. Benson CS, Shah A, Stanworth SJ. The effect of iron deficiency and anaemia on women’s health. Anaesthesia. 2021;76 Suppl 4: 84–95. doi: https://doi.org/10.1111/anae.15405


Review

For citations:


Adamyan L.V., Sibirskaya E.V., Karachentsova I.V., Pivazyan L.G., Loshkareva M.A., Kirillova Yu.A., Murvatova S.K., Murvatova K.K. Abnormal Uterine Bleeding in Adolescence Burdened with Severe Anemia: Clinical Case. Current Pediatrics. 2023;22(4):319-323. (In Russ.) https://doi.org/10.15690/vsp.v22i4.2612

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