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Роль нарушений барьерной функции кишечника в развитии пищевой аллергии у детей

https://doi.org/10.15690/vsp.v12i2.615

Аннотация

Кишечный эпителиальный барьер играет важнейшую роль в поддержании кишечного гомеостаза, препятствует проникновению бактерий и пищевых аллергенов из просвета кишечника. Рассматриваются нарушения функции эпителиального барьера, способствующие развитию сенсибилизации. Особое внимание уделяется молекулярным механизмам, обеспечивающим увеличение трансцитоплазменного переноса аллергенов. Фаза сенсибилизации при аллергии характеризуется антиген-индуцированным перекрестным связыванием IgE с высокоаффинным FcRI-рецептором на поверхности тучных клеток, что приводит к анафилактической реакции.

Об авторах

Т. Э. Боровик
Научный центр здоровья детей РАМН, Москва; Первый Московский государственный медицинский университет им. И.М. Сеченова
Россия


С. Г. Макарова
Научный центр здоровья детей РАМН, Москва; Первый Московский государственный медицинский университет им. И.М. Сеченова
Россия


Г. В. Яцык
Научный центр здоровья детей РАМН, Москва
Россия


Т. Н. Степанова
Научный центр здоровья детей РАМН, Москва
Россия


С. Г. Грибакин
Российская медицинская академия последипломного образования, Москва
Россия


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Рецензия

Для цитирования:


Боровик Т.Э., Макарова С.Г., Яцык Г.В., Степанова Т.Н., Грибакин С.Г. Роль нарушений барьерной функции кишечника в развитии пищевой аллергии у детей. Вопросы современной педиатрии. 2013;12(2):12-19. https://doi.org/10.15690/vsp.v12i2.615

For citation:


Borovik T.E., Makarova S.G., Yatsyk G.V., Stepanova T.N., Gribakin S.G. Role of the Barrier Dysfunction of the Intestines in the Development of Alimentary Allergy in Children. Current Pediatrics. 2013;12(2):12-19. (In Russ.) https://doi.org/10.15690/vsp.v12i2.615

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