Известные и неизвестные эффекты витамина D
https://doi.org/10.15690/vsp.v12i2.616
Аннотация
Проблема дефицита витамина D в настоящее время приобретает особое значение, поскольку, по данным многочисленных исследований, гиповитаминоз D имеется почти у 1/2 населения мира. В статье представлены эпидемиологические данные, касающиеся обеспеченности холекальциферолом детей различных возрастных групп, и определены современные подходы к оценке содержания витамина D в организме. Особое внимание уделено представлениям о метаболизме и биологических функциях витамина D, заключающихся не только в положительном его воздействии на состояние костной ткани, но и во многих внекостных биологических эффектах.
К
К
Ключевые слова
Об авторах
И. Н. Захарова
Российская медицинская академия последипломного образования, Москва
Россия
Россия
С. В. Яблочкова
Российская медицинская академия последипломного образования, Москва
Россия
Россия
Ю. А. Дмитриева
Российская медицинская академия последипломного образования, Москва
Россия
Россия
Список литературы
1. Holick M. F. Vitamin D deficiency. N. Engl. J. Med. 2007; 357: 266–281.
2. Holick M. F. Vitamin D status: measurement, interpretation and clinical application. Ann. Epidemiol. 2009; 19 (2): 73–78.
3. Korovina N. A., Zakharova I. N., Dmitriyeva Yu. A. Modern concep tion of vitamin D physiological role in healthy and ill children. Zhurnal imeni G. N. Speranskogo — Pediatrics. 2008; 87 (4): 124–129.
4. Zakharova I. N., Korovina N. A., Borovik T. E., Dmitriyeva Yu. A. Rachitis and hypovitaminosis В — the new look on the existing problem. Handbook for doctors. Moscow. 2010. 96 pp.
5. Holick M. F. Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers and cardiovascular disease. Am J Clin Nutr. 2004; 80: 1678–1688.
6. Bouillon R., Carmeliet G., Daci E., Segaert S., Verstuyf A. Vitamin D metabolism and action. Osteoporosis Int. 1998; 519: 8513–8519.
7. Plum L. A., DeLuca H. F. The functional metabolism and molecular biology of vitamin D action. In: M. F. Holick, ed. Vitamin D: Physiology, Molecular Biology, and Clinical Applications. 2nd edn. N.-Y: Humana Press. 2010. P. 61–97.
8. Zakharovam I. N., Korovina N. A., Dmitriyeva Yu. A. The role of metabolites of vitamin D in children with rachitis. Zhurnal imeni G. N. Speranskogo — Pediatrics. 2010; 89 (3): 68–73.
9. Dawson-Hughes B., Heaney R. P., Holick M. F., Lips P., Meunier P. J., Vieth R. Estimates of optimal vitamin D status. Osteoporos Int. (Editorial). 2005; 16: 713–716.
10. Brown E. M., Gamba G., Riccardi D., Lombardi M., Butters R., Kifor O., Sun A., Hediger M. A., Lytton J., Hebert S. C. Cloning and characterization of an extracellular Ca2+-sensing receptor from bovine parathyroid. Nature. 1993; 366: 575–580.
11. Holick M. F., Garabedian M. Vitamin D: photobiology, metabolism, mechanism of action, and clinical applications. In: M. J. Favus (ed.). Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism. 6th edn. Ch. 17. American Society for Bone and Mineral Research. Washington, DC. 2006. P. 129–137.
12. Bischoff-Ferrari H. A., Giovannucci E., Willett W. C., Dietrich T., Dawson-Hughes B. Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes. Am. J. Clin. Nutr. 2006; 84: 18–28.
13. Vieth R., Bischoff-Ferrari H., Boucher B. J., Dawson-Hughes B., Garland C. F., Heaney R. P., Holick M. F., Hollis B. W., Lamber-Allardt C., McGrath J. J., Norman A. W., Scragg R., Whiting S. J., Willett W. C., Zittermann A. The urgent need to recommend an intake of vitamin D that is effective. Am. J Clin. Nutr. 2007; 85: 649–650.
14. Need A. G. Bone resorption markers in vitamin D insufficiency. Clin. Chim. Acta. 2006; 368: 48–52.
15. Koutkia P., Chen T. C., Holick M. F. Vitamin D intoxication associated with an over-the-counter supplement. N. Engl. J. Med. 2001; 345 (1): 66–67.
16. Pettifor J. M. Vitamin D and/or calcium deficiency rickets in infants and children: a global perspective. Indian J. Med. Res. 2008; 127: 245–249.
17. NIH Consensus Development Conference on Osteoporosis: Prevention, Diagnosis and Therapy. JAMA. 2000; 287: 785–795.
18. Korovina N. A., Tvorogova T. M., Gavryushova L. P., Zakharova I. N., Tupikina N. V. Osteoporosis in children. Educational textbook for doctors. Moscow. 2002. 52 pp.
19. van der Mei I. A., Ponsonby A. L., Dwyer T. Past exposure to sun, skin phenotype, and risk of multiple sclerosis: case-control study. BMJ. 2003; 327: 316.
20. Janner M., Ballinari P., Mullis P. E., Fluck Ch. E. High prevalence of vitamin D deficiency in children and adolescents with type 1 diabetes. Swiss Med. Wkly. 2010; 140: 13091.
21. Greer R. M., Rogers M. A., Bowling F. G., Buntain H. M., Harris M., Leong G. M., Cotterill A. M. Australian children and adolescents with type 1 diabetes have low vitamin D levels. Med. J. Aust. 2007; 187: 59–60.
22. Pozzilli P., Manfrini S., Crino A., Picardi A., Leomanni C., Cherubini V., Valente L., Khazrai M., Visalli N., Pozzilli P., Manfrini S., Crino A., Picardi A., Leomanni C., Cherubini V., Valente L., Khazrai M., Visalli N. IMDIAB group. Low levels of 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 in patients with newly diagnosed type 1 diabetes. Horm. Metab. Res. 2005; 37: 680–683.
23. Svoren B. M., Volkening L. K., Wood J. R., Laffel L. M. Significant vitamin D deficiency in youth with type 1 diabetes mellitus. J. Pediatr. 2009; 154: 132–134.
24. Zipitis C. S., Akobeng A. K. Vitamin D supplementation in early childhood and risk of type 1 diabetes: a systematic review and metaanalysis. Arch. Dis. Child. 2008; 93 (6): 512–517.
25. Berk M. Vitamin D: is it relevant to psychiatry? Acta Neuropsychiatrica. 2009; 21 (21); 205–206.
26. Thomas J., Al-Anouti F., Al-Hasani S., Abdel-Wareth L., Haq A. Sunshine, Sadness and Seasonality: 25 Hydroxyvitamin D and depressive symptoms in United Arab Emirates (UAE). Int. J. Ment. Health Promotion. 2011; 13: 23–26.
27. Tolppanen A.-M., Sayers A., Fraser W. D., Lewis G., Zammit S., Lawlor D. A. The association of serum 25-hydroxyvitamin D3 and D2 with depressive symptoms in childhood — a prospective cohort study. J Child Psychol Psychiatry. 2012 Jul; 53 (7): 757–66.
28. Shellhaas R. A., Barks A. K., Joshi S. M. Prevalence and risk factors for vitamin D insufficiency among children with epilepsy. Pediatr. Neurol. 2010; 42 (6): 422–426.
29. Bryce J., Boschi-Pinto C., Shibuya K., Black R. E. WHO estimates of the causes of death in children. Lancet. 2005; 365: 1147–1152.
30. Muhe L., Lulseged S., Mason K. E., Simoes E. A. Case-control study of the role of nutritional rickets in the risk of developing pneumonia in Ethiopian children. Lancet. 1997; 349: 1801–1804.
31. Najada A. S., Habashneh M. S., Khader M. The frequency of nutritional rickets among hospitalized infants and its relation to respiratory diseases. J. Trop. Pediatr. 2004; 50: 364–368.
32. Wayse V., Yousafzai A., Mogale K., Filteau S. Association of subclinical vitamin D deficiency with severe acute lower respiratory infection in Indian children under 5 y. Eur. J. Clin. Nutr. 2004; 58: 563–567.
33. Karatekin G., Kaya A., Salihoglu O., Balci H., Nuhoglu A. Association of subclinical vitamin D deficiency in newborns with acute lower respiratory infection and their mothers. Eur. J. Clin. Nutr. 2009; 63: 473–477.
34. Ginde A. A., Mansbach J. M., Camargo C. A., Jr. Association between serum 25-hydroxyvitamin D level and upper respiratory tract infection in the Third National Health and Nutrition Examination Survey. Arch. Intern. Med. 2009; 169 (4): 384–390.
35. McNally J. D., Leis K., Matheson L. A., Karuananyake C., Sankaran K., Rosenberg A. M. Vitamin D deficiency in young children with severe acute lower respiratory infection. Pediatr. Pulmonol. 2009; 44 (10): 981–988.
36. Urashima M., Segawa T., Okazaki M., Kurihara M., Wada Y., Ida H. Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren. Am. J. Clin. Nutr. 2010; 91 (5): 1255–1260.
37. Camargo C. A., Jr., Ganmaa D., Frazier A. L., Kirchberg F. F., Stuart J. J., Kleinman K., Sumberzul N., Rich-Edwards J. W. Randomized trial of vitamin D supplementation and risk of acute respiratory tract infection in Mongolia. Pediatrics. 2012; 130 (3): 561–567.
38. Belderbos M. E., Houben M. L., Wilbrink B., Lentjes E., Bloemen E. M., Kimpen J. L., Rovers M., Bont L. Cord blood vitamin D deficiency is associated with respiratory syncytial virus bronchiolitis. Pediatrics. 2011; 127 (6): 1513–1520.
39. Norms of physiological need in energy and food substances for different groups of population in Russian Federation. Methodic recommendations. МР 2.3.1.2432-08 (
Рецензия
Для цитирования:
Захарова И.Н., Яблочкова С.В., Дмитриева Ю.А. Известные и неизвестные эффекты витамина D. Вопросы современной педиатрии. 2013;12(2):20-25. https://doi.org/10.15690/vsp.v12i2.616
For citation:
Zakharova I.N., Yablochkova S.V., Dmitrieva Yu.A. Well-known and Indeterminate Effects of Vitamin D. Current Pediatrics. 2013;12(2):20-25. (In Russ.) https://doi.org/10.15690/vsp.v12i2.616
Просмотров:
1421
Послать статью по эл. почте 
