Efficacy of usage of pneumococcal 7-valent vaccine in prophylaxis of pneumococcal infection in Novosibirsk children from risk groups
https://doi.org/10.15690/vsp.v12i2.630
Abstract
In order to prevent children morbidity and mortality 116 children aged from 6 months to 5 years from 2 risk groups (1 — with bronchial-pulmonary dysplasia and 2 — with congenital heart defects) were vaccinated with pneumococcal 7-valent conjugated vaccine in 2011 at the expense of municipal budget. Among 116 children from both groups 16 (14%) have had community-acquired pneumonia, which is 22 times higher than in general children population in this region. Dynamic 1-year follow-up showed significant decrease of community-acquired pneumonia prevalence in risk groups: from 16/116 (14%) to 1/75 (1%) (p =0,006). There were no cases of invasive pneumococcal infections among vaccinated children and in 87,5% of them the general morbidity decreased. The frequency of moderate general post-vaccinal reactions was 1,8%, topical reactions — 0,9%. There were no other side effects during post-vaccinal period. Thereafter, the vaccination against pneumococcal infection performed in Novosibirsk in children with risk of fatal complications showed high efficacy and safety of the used vaccine.
About the Authors
O. A. Beletskaya
Department of Obstetrics and Organization of Specialized Medical Care to Children of the Novosibirsk City Administration, Russian Federation
Yu.N. Gorbatykh
E.N. Meshalkin Novosibirsk Scientific Research Institute of Blood Circulation Disorders,
Russian Federation
Russian Federation
A. N. Shmakov
Novosibirsk State Medical University
Russian Federation
Russian Federation
N. Yu. Ishalina
Geras’kov Children Municipal Clinical Hospital №4, Novosibirsk
Russian Federation
Russian Federation
T. Yu. Ivleva
Municipal Children Out-Patient Clinic №2, Novosibirsk
Russian Federation
Russian Federation
N. V. Kukhtinova
Novosibirsk State Medical University
Russian Federation
Contacts: Kukhtinova Natalya Vladilenovna, PhD, MD, assistant of a Chair of Pediatrics, Novosibirsk State Medical University Address: 630091, Novosibirsk, Krasnyy Prospect, 52, Tel.: (383) 223-67-21, e-mail: natalya_kuhtinov@mail.ru
Russian Federation
Contacts: Kukhtinova Natalya Vladilenovna, PhD, MD, assistant of a Chair of Pediatrics, Novosibirsk State Medical University Address: 630091, Novosibirsk, Krasnyy Prospect, 52, Tel.: (383) 223-67-21, e-mail: natalya_kuhtinov@mail.ru
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Review
For citations:
Beletskaya O.A., Gorbatykh Yu., Shmakov A.N., Ishalina N.Yu., Ivleva T.Yu., Kukhtinova N.V. Efficacy of usage of pneumococcal 7-valent vaccine in prophylaxis of pneumococcal infection in Novosibirsk children from risk groups. Current Pediatrics. 2013;12(2):123-126. (In Russ.) https://doi.org/10.15690/vsp.v12i2.630
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