Современные возможности терапии гнездной алопеции
https://doi.org/10.15690/vsp.v23i6.2825
Аннотация
Гнездная алопеция — хроническое генетически детерминированное воспалительное аутоиммунное заболевание, протекающее с поражением волосяных фолликулов, приводящим к временному или стойкому нерубцовому выпадению волос. Для лечения зарегистрированы ингибиторы янус-киназ, позволяющие персонализировать терапию и повысить ее эффективность за счет купирования симптомов и положительного влияния на качество жизни пациентов. Эта группа препаратов рассматривается в качестве основы терапии тяжелых форм гнездной алопеции. Обсуждается проблема развития рецидивов после отмены ингибиторов янус-киназ, а также безопасность длительной поддерживающей терапии препаратами этого класса.
Ключевые слова
гнездная алопеция,
ингибиторы янус-киназ,
JAK,
тофацитиниб,
барицитиниб,
аброцитиниб,
ритлецитиниб,
JAK/STAT
При поддержке: Отсутствует.
Об авторах
Э. Т. Амбарчян
НИИ педиатрии и охраны здоровья детей НКЦ №2 ФГБОУ ВО «РНЦХ им. акад. Б.В. Петровского»
Россия
Раскрытие интересов:
Россия
Амбарчян Эдуард Тигранович - кандидат медицинских наук, заведующий отделением дерматологии
117593, Москва, Литовский бульвар, д. 1а
тел.: +7 (915) 400-00-02
Раскрытие интересов:
Э.Т. Амбарчян — получение исследовательских грантов от компаний Eli Lilly, Novartis, AbbVie, Pfizer, Amryt Pharma plc, гонораров за научное консультирование от Johnson & Johnson.
В. В. Иванчиков
НИИ педиатрии и охраны здоровья детей НКЦ №2 ФГБОУ ВО «РНЦХ им. акад. Б.В. Петровского»
Россия
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Россия
Москва
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Автор статьи подтвердил отсутствие конфликта интересов, о котором необходимо сообщить.
А. Д. Алексеева
НИИ педиатрии и охраны здоровья детей НКЦ №2 ФГБОУ ВО «РНЦХ им. акад. Б.В. Петровского»
Россия
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Россия
Москва
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О. Б. Гордеева
НИИ педиатрии и охраны здоровья детей НКЦ №2 ФГБОУ ВО «РНЦХ им. акад. Б.В. Петровского»
Россия
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Россия
Москва
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Автор статьи подтвердил отсутствие конфликта интересов, о котором необходимо сообщить.
Л. С. Намазова-Баранова
НИИ педиатрии и охраны здоровья детей НКЦ №2 ФГБОУ ВО «РНЦХ им. акад. Б.В. Петровского»; РНИМУ им. Н.И. Пирогова (Пироговский Университет)
Россия
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Россия
Москва
Раскрытие интересов:
Л.С. Намазова-Баранова — получение исследовательских грантов от фармацевтических компаний «Пьер Фабр», Genzyme Europe B.V., «Астразенека Фармасьютикалз», Gilead / PRA «Фармасьютикал Рисерч Ассошиэйтс СиАйЭс», Teva Branded Pharmaceutical products R&D, «ППД Девелопмент (Смоленск)», «Сталлержен С. А. / Квинтайлс ГезмбХ».
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Рецензия
Для цитирования:
Амбарчян Э.Т., Иванчиков В.В., Алексеева А.Д., Гордеева О.Б., Намазова-Баранова Л.С. Современные возможности терапии гнездной алопеции. Вопросы современной педиатрии. 2024;23(6):516-522. https://doi.org/10.15690/vsp.v23i6.2825
For citation:
Ambarchyan E.T., Ivanchikov V.V., Alekseeva A.D., Gordeeva O.B., Namazova-Baranova L.S. Modern Management Approaches for Alopecia Areata. Current Pediatrics. 2024;23(6):516-522. (In Russ.) https://doi.org/10.15690/vsp.v23i6.2825
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