SEROTYPE CHARACTERISTIC OF PNEUMOCOCCI ISOLATED FROM PATIENTS WITH PNEUMOCOCCAL MENINGITIS
https://doi.org/10.15690/vsp.v11i4.370
Abstract
As it was reported by World Health Organization, the annual number of deaths caused by pneumococci reaches 1,6 million people including 700 thousand of children of 0–5 years old. Pneumococcal meningitis is one of the most severe manifestations of pneumococcal infection. S. pneumoniae keeps one of the leading positions in aetiological structure of bacterial meningitis. Data on serotypes distribution of pneumococci in children of the early age in the Russian Federation are limited. In this study serotypes of pneumococci from pediatric patients with pneumococcal meningitis (children aged 0–7 years, n =35) isolated in 1981–2010 in Moscow were identified. Screening for sensitivity of strains to penicillin was performed, as well as molecular typing by MLST approach. The most frequent serotypes causing pneumococcal meningitis in children aged 0–7 years were 19F, 7F, 14 and 1. Most of MDR-strains were collected in 2007–2009. Among MDR-strains and those demonstrating increased resistance to antibiotics, several new allelic patterns were described.
About the Authors
I. S. Koroleva
Central Scientific Research Institute of Epidemiology, Russian Agency for Health and Consumer Rights, Moscow
Russian Federation
Irina Koroleva, Doctor of Medical Science, professor, head of the laboratory
Russian Federation
Irina Koroleva, Doctor of Medical Science, professor, head of the laboratory
G. V. Beloshitsky
Central Scientific Research Institute of Epidemiology, Russian Agency for Health and Consumer Rights, Moscow
Russian Federation
Russian Federation
K. O. Mironov
Central Scientific Research Institute of Epidemiology, Russian Agency for Health and Consumer Rights, Moscow
Russian Federation
Russian Federation
References
1. Pneumococcal conjugate vaccine for childhood immunization — WHO position paper. WHO. 2007; 12 (82): 93–104.
2. Sigurdardottir B., Bjornsson O. M. et al. Acute bacterial meningitis in adults. A 20-year overview. Arch. Intern. Med. 1997; 157: 425–429.
3. Schuchat A., Robinson K., Wenger J. D. et al. Bacterial meningitis in the United States in 1995. Active Surveillance Team. N. Engl. J. Med. 1997; 337: 970–976.
4. McIntosh E. D. G., Fritzell B., Fletcher M. A. Burden of paediatric invasive pneumococcal disease in Europe, 2005. Epidemiology and Infection. 2007; 135 (4): 644–656.
5. Hausdorff W. P., Bryant J., Paradiso P. R., Siber G. R. Which pneumococcal serogroups cause the most invasive disease: implications for conjugate vaccine formulation and use, part I. Clin. Infect. Diseases. 2000; 30 (1): 100–121.
6. Quagliarello V. J., Scheld W. M. Treatment of bacterial meningitis. N. Engl. J. Med. 1997; 336 (10): 708–716.
7. Баранов А. А., Омельяновский В. В., Брико Н. И. и др. Результаты фармакоэкономического анализа применения пневмококковой конъюгированной 7-валентной вакцины для профилактики пневмококковых инфекций у детей первых 5 лет жизни в Российской Федерации. Педиатрическая фармакология. 2009; 6 (6): 6–10.
8. Hsu H. E., Shutt K. A., Moore M. R. Effect of pneumococcal conjugate vaccine on pneumococcal meningitis. N. Engl. J. Med. 2009; 360 (3): 244–256.
9. Grijalva C. G., Nuorti J. P., Arbogast P. G. Decline in pneumonia admissions after routine childhood immunization with pneumococcal conjugate vaccine in the USA: a time-series analysis. Lancet. 2007; 369 (9568): 1179–1186.
10. Королева И. С., Белошицкий Г. В. Эпидемиологическая характеристика пневмококкового менингита у детей в возрасте до 6 лет в Российской Федерации. Эпидемиология и инфекционные болезни. Актуальные вопросы. 2012; 1: 18–21.
11. Белошицкий Г. В., Королева И. С., Сафонов А. В. Эпидемиологические особенности пневмококкового менингита в Москве за период с 2006 по 2010 гг. Медицинский алфавит. Эпидемиология и гигиена. 2012; 1: 28–30.
12. Сорокина М. Н. Бактериальные гнойные менингиты у детей. Вакцинация. 1999; 2: 15–17.
13. Козлов Р. С. и др. Антибиотикорезистентность Streptococcus pneumoniae в России в 1999–2005 гг.: результаты многоцентровых проспективных исследований ПеГАС-I и ПеГАС-II. КМАХ. 2006; 8 (1): 33–47.
14. Белошицкий Г. В., Королева И. С., Кошкина Н. И. Пневмококковые менингиты в Российской Федерации. Эпидемиология и вакцинопрофилактика, 2009; 2 (45): 21–26.
15. Enright M., Spratt B. G. A multilocus sequence typing scheme for Streptococcus pneumoniae: identification of clones associated with serious invasive disease. Microbiology. 1998; 144: 3049–3060.
Review
For citations:
Koroleva I.S., Beloshitsky G.V., Mironov K.O. SEROTYPE CHARACTERISTIC OF PNEUMOCOCCI ISOLATED FROM PATIENTS WITH PNEUMOCOCCAL MENINGITIS. Current Pediatrics. 2012;11(4):122-127. (In Russ.) https://doi.org/10.15690/vsp.v11i4.370
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