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ВАКЦИНА АБКДС-ИПВ//PRP~T: ОБЗОР 16-ЛЕТНЕГО ОПЫТА КЛИНИЧЕСКОГО ПРИМЕНЕНИЯ

https://doi.org/10.15690/vsp.v11i1.129

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Аннотация

Благодаря низкой реактогенности, подтвержденной эффективности и включенным в состав ацеллюлярному (бесклеточному) коклюшному компоненту и инактивированной полиовакцине, многокомпонентные комбинированные вакцины в настоящее время широко используют в национальных программах иммунизации по всему миру. Мы представляем обзор 16-летнего опыта клинического применения комбинированной вакцины Пентаксим (АбКДС-ИПВ//PRP~T; Санофи Пастер, Франция), содержащей бесклеточный коклюшный компонент, дифтерийный анатоксин, столбнячный анатоксин, инактивированную полиовакцину и очищенный капсульный полисахарид (PRP) гемофильной палочки типа b (Haemophilus influenzae type b, Hib), конъюгированный со столбнячным протеином (Т). Исследования продемонстрировали высокую иммуногенность первичной вакцинации Пентаксимом независимо от этнических характеристик популяции и схемы введения. Ревакцинация на втором году жизни также приводила к выраженному иммунному ответу на каждый из антигенов. Кроме того, результаты 10-летнего национального исследования в Швеции продемонстрировали эффективность исследуемой вакцины в контроле заболеваемости коклюшем. Как и другие комбинированные вакцины, содержащие бесклеточный коклюшный компонент, вакцина хорошо переносится, при этом ее характеристики безопасности при первичной вакцинации и ревакцинации лучше, чем у комбинированных вакцин, содержащих цельноклеточный коклюшный компонент.

Об авторах

Stanley А. Plotkin
Компания Ваксконсалт (Vaxconsult), Пенсильвания
Соединённые Штаты Америки

Стенли Плоткин, Почетный профессор Университета Пенсильвании, США

Адрес: Global Medical Affairs, Sanofi Pasteur, 2 Avenue Pont Pasteur, 69367 Lyon,тел.: +33 437 377 258, fax: +33 437 377, e-mail: 171esteban.ortiz@sanofipasteur.com


Johannes Liese
Детский университетский госпиталь, Вюрцбург
Германия


Shabir А. Madhi
Университет Витватерсранда, Йоханнесбург
Южно-Африканская Республика


Esteban Ortiz
Санофи Пастер, Лион
Франция


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Для цитирования:


Plotkin S.А., Liese J., Madhi S.А., Ortiz E. ВАКЦИНА АБКДС-ИПВ//PRP~T: ОБЗОР 16-ЛЕТНЕГО ОПЫТА КЛИНИЧЕСКОГО ПРИМЕНЕНИЯ. Вопросы современной педиатрии. 2012;11(1):18-36. https://doi.org/10.15690/vsp.v11i1.129

For citation:


Plotkin S.A., Liese J., Madhi S., Ortiz E. A DTAP–IPV//PRP~T VACCINE: A REVIEW OF 16 YEARS’ CLINICAL EXPERIENCE. Current pediatrics. 2012;11(1):18-36. (In Russ.) https://doi.org/10.15690/vsp.v11i1.129

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