EFFICACY AND SAFETY OF PEDIATRIC JUVENILE IDIOPATHIC ARTHRITIS AND UVEITIS TREATMENT WITH ADALIMUMAB
https://doi.org/10.15690/vsp.v11i1.141
Abstract
The article contains results of the study of efficacy and safety of adalimumab treatment given to 110 patients with juvenile idiopathic arthritis (JIA) and arthritis with eye-lesions, refractory to classical immunosuppressive treatment. Follow up period was from 3 months
to 1 year long. The dosage regimen was as follows — 1 subcutaneous injection of Adalimumab 40 mg once in 2 weeks. Against the background of treatment with anti-TNF agents clinical remission, decrease and normalization of lab parameters of the disease activity, lower degree of disability, quality of life increase in 100 patients (90%), decrease in uveitis activity (N = 9, 18.75%), and remission of uveitis (N=39, 81.25%) were achieved. During the follow up period there were no adverse events that lead to drug withdrawal. Thereby, Adalimumab treatment is pathogenetically justified, effective and safe for patients with JIA and uveitis.
to 1 year long. The dosage regimen was as follows — 1 subcutaneous injection of Adalimumab 40 mg once in 2 weeks. Against the background of treatment with anti-TNF agents clinical remission, decrease and normalization of lab parameters of the disease activity, lower degree of disability, quality of life increase in 100 patients (90%), decrease in uveitis activity (N = 9, 18.75%), and remission of uveitis (N=39, 81.25%) were achieved. During the follow up period there were no adverse events that lead to drug withdrawal. Thereby, Adalimumab treatment is pathogenetically justified, effective and safe for patients with JIA and uveitis.
About the Authors
E. I. Alexeeva
Scientific Centre of Children’s Health RAMS, Moscow
Sechenov First Moscow Medical University
Russian Federation
Ekaterina Iosifovna Alexeeva, PhD, professor, Head of the Pediatric Department of I.M. Sechenov First MSMU, Head of the Rheumatologic Department of SCCH of RAMS
Russian Federation
Ekaterina Iosifovna Alexeeva, PhD, professor, Head of the Pediatric Department of I.M. Sechenov First MSMU, Head of the Rheumatologic Department of SCCH of RAMS
E. V. Mitenko
Scientific Centre of Children’s Health RAMS, Moscow
Russian Federation
Russian Federation
S. I. Valieva
Scientific Centre of Children’s Health RAMS, Moscow
Russian Federation
Russian Federation
T. M. Bzarova
Scientific Centre of Children’s Health RAMS, Moscow
Russian Federation
Russian Federation
R. V. Denisova
Scientific Centre of Children’s Health RAMS, Moscow
Russian Federation
Russian Federation
K. B. Isaeva
Scientific Centre of Children’s Health RAMS, Moscow
Russian Federation
Russian Federation
T. V. Sleptsova
Scientific Centre of Children’s Health RAMS, Moscow
Russian Federation
Russian Federation
A. M. Tchomakhidze
Scientific Centre of Children’s Health RAMS, Moscow
Russian Federation
Russian Federation
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Review
For citations:
Alexeeva E.I., Mitenko E.V., Valieva S.I., Bzarova T.M., Denisova R.V., Isaeva K.B., Sleptsova T.V., Tchomakhidze A.M. EFFICACY AND SAFETY OF PEDIATRIC JUVENILE IDIOPATHIC ARTHRITIS AND UVEITIS TREATMENT WITH ADALIMUMAB. Current Pediatrics. 2012;11(1):111-118. (In Russ.) https://doi.org/10.15690/vsp.v11i1.141
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