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Вопросы современной педиатрии

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ПРОДУКТЫ МЕТАБОЛИЗМА КИШЕЧНОЙ МИКРОФЛОРЫ: ВОЗМОЖНА ЛИ ИЗБИРАТЕЛЬНАЯ КОРРЕКЦИЯ?

https://doi.org/10.15690/vsp.v14i2.1289

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Аннотация

Нарушение количественных и качественных характеристик кишечной микробиоты — одна из причин развития широкого спектра патологических состояний в любой возрастной группе. С целью коррекции подобных нарушений используют пробиотики (препараты активной микрофлоры) и пребиотики (олигосахариды, способствующие росту позитивной флоры). Перспективно применение и метаболических пребиотиков — экстрактов продуктов обмена веществ позитивной флоры, которые, подобно олигосахаридным пребиотикам, стимулируют рост микробиоты. Сравнительный анализ метаболома некоторых представителей кишечной микрофлоры и препаратов, содержащих продукты обмена бактерий, позволяет понять механизмы их терапевтического воздействия, открывает перспективы разработки комплексного воздействия при использовании с витаминами В6, В2, каротиноидами, селеном, глутатионом. Результаты метаболомного анализа дают возможнось утверждать, что метаболиты таких представителей микрофлоры, как Escherichia coli, Streptococcus faecalis, Lactobacillus acidophilus, Lactobacillus helveticus, способствуют выживанию позитивной флоры и в то же время могут тормозить рост патогенной микрофлоры.

 

Об авторах

А. И. Хавкин
Российский научно-исследовательский медицинский университет им. Н.И. Пирогова, Москва, Российская Федерация
Россия

доктор медицинских наук, профессор, заведующий отделом гастроэнтерологии НИКИ педиатрии РНИМУ им. Н.И. Пирогова
Адрес: 125412, Москва, ул. Талдомская, д. 2, тел.: +7 (499) 487-46-81



О. Н. Комарова
Российский научно-исследовательский медицинский университет им. Н.И. Пирогова, Москва, Российская Федерация
Россия


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Для цитирования:


Хавкин А.И., Комарова О.Н. ПРОДУКТЫ МЕТАБОЛИЗМА КИШЕЧНОЙ МИКРОФЛОРЫ: ВОЗМОЖНА ЛИ ИЗБИРАТЕЛЬНАЯ КОРРЕКЦИЯ? Вопросы современной педиатрии. 2015;14(2):212-218. https://doi.org/10.15690/vsp.v14i2.1289

For citation:


Khavkin A.I., Komarova O.N. PRODUCTS OF METABOLISM OF THE INTESTINAL MICROFLORA: CAN WE USE THE SELECTIVE CORRECTION? Current Pediatrics. 2015;14(2):212-218. (In Russ.) https://doi.org/10.15690/vsp.v14i2.1289

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