Preview

Current Pediatrics

Advanced search

HUMAN MONOCLONAL ANTIBODIES TO TNF: NEW OPPORTUNITIES IN TREATMENT OF JUVENILE IDIOPATHIC SPONDYLITIS

Abstract

This article contains an example of a successful clinical use of human monoclonal antibodies to tumor necrosis factor (TNF) — adalimumab in patients with severe juvenile idiopathic spondylitis, characterized by resistance to standard antirheumatic treatment and secondary resistance to recombinant (chimeric) antibodies to TNF. Adalimumab treatment in a short time has helped to overcome secondary ineffectiveness of infliximab treatment, to rapidly decrease the activity of the disease, to reach functional improvement of peripheric joints, to improve patient’s quality of life. The aforesaid medication has stopped steady progression of further incapacitation of the patient and has evoked clinical remission of the disease.
Key words: children, juvenile idiopathic spondylitis, adalimumab, treatment.
(Voprosy sovremennoi pediatrii — Current Pediatrics. 2011; 10 (3): 150–156)

About the Authors

R.V. Denisova
Sсientific Center of Children’s Health, Russian Academy of Medical Sciences, Moscow


E.I. Alekseeva
Sсientific Center of Children’s Health, Russian Academy of Medical Sciences, Moscow I.M. Sechenov First Moscow State Medical University


References

1. Cassidy J., Petty R. Texbook of paediatric rheumatology. 5 еd. Philadelphia: Elsevier Saunders. 2005.

2. Алексеева Е.И., Григорьева А.А., Денисова Р.В. Причины развития резистентности к ингибиторам ФНО α и пути ее преодоления. Вопросы современной педиатрии. 2009; 8 (6): 42–47.

3. Алексеева Е.И., Лисицин А.О., Карагулян Н.А. Адалимумаб: новые возможности лечения ювенильных артритов. Вопросы современной педиатрии. 2009; 8 (3): 88–94.

4. Van der Heijde D., Kivitz A., Schiff M.H. et al. Efficacy and safety of adalimumab in patients with ankylosing spondylitis. Arthritis Rheum. 2006; 54 (7): 2136–2146.

5. Davis J.C., Revicki D., van der Heijde D.M. et al. Health-related quality of life outcomes in patients with active ankylosing spondylitis treated with adalimumab: results from a randomized controlled study. Arthritis Rheum. 2007; 57: 1050–1057.

6. Revicki D.A., Luo M.P. et al. Adalimumab reduces pain, fatigue, and stiffness in patients with ankylosing spondylitis: results from the adalimumab trial evaluating long-term safety and efficacy for ankylosing spondylitis (ATLAS). J. Rheumatol. 2008; 35 (7): 1346–1353.

7. Van der Heijde D., Schiff M.H., Sieper J. et al. Adalimumab effectiveness for the treatment of ankylosing spondylitis is maintained for up to 2 years: long-term results from the ATLAS trial. Ann. Rheum. Dis. 2009; 68 (6): 922–929.

8. Lambert R.G., Salonen D. et al. Adalimumab significantly reduces both spinal and sacroiliac joint inflammation in patients with ankylosing spondylitis: a multicenter, randomized, double-blind, placebo-controlled study. Arthritis Rheum. 2007; 56 (12): 4005–4014.

9. Van der Heijde D., Pangan A.L., Schiff M.H. Adalimumab effectively reduces the signs and symptoms of active ankylosing spondylitis in patients with total spinal ankylosis. Ann. Rheum. Dis. 2008; 67 (9): 1218–1221.

10. Rudwaleit M., Claudepierre P., Kron M. et al. Effectiveness of adalimumab in treating patients with ankylosing spondylitis associated with enthesitis and peripheral arthritis. Arthritis Res. Ther. 2010; 12 (2): 43.

11. Van der Heijde D., Salonen D., Weissman B.N., Landewé R. et al. Assessment of radiographic progression in the spines of patients with ankylosing spondylitis treated with adalimumab for up to 2 years. Arthritis Res. Ther. 2009; 11 (4): 127.

12. Van der Heijde D.M., Revicki D.A. et al. Physical function, disease activity, and health-related quality of life outcomes after 3 years of adalimumab treatment in patients with ankylosing spondylitis. Arthritis Res. Ther. 2009; 11 (4): 124.

13. Rudwaleit M., Claudepierre P.J. et al. Effectiveness, safety, and predictors of good clinical response in 1250 patients treated with adalimumab for active ankylosing spondylitis. Rheumatol. 2009; 36 (4): 801–808.

14. Rudwaleit M., Olivieri I., Boki K.A. Adalimumab is effective and well tolerated in treating patients with ankylosing spondylitis who have advanced spinal fusion. Rheumatology (Oxford). 2009; 48 (5): 551–557.

15. Sulpice M., Deslandre C.J., Quartier P. Efficacy and safety of TNF alpha antagonist therapy in patients with juvenile spondyloarthropathies. Joint Bone Spine. 2009; 76 (1): 24–27.


Review

For citations:


Denisova R., Alekseeva E. HUMAN MONOCLONAL ANTIBODIES TO TNF: NEW OPPORTUNITIES IN TREATMENT OF JUVENILE IDIOPATHIC SPONDYLITIS. Current Pediatrics. 2011;10(3):150–156.

Views: 773


ISSN 1682-5527 (Print)
ISSN 1682-5535 (Online)