BRONCHIAL OBSTRUCTION IN CHILDREN: A NEW SOLUTION TO AN OLD PROBLEM
https://doi.org/10.15690/vsp.v14i2.1298
Abstract
Bronchial obstruction is a widespread pathological condition in children. The development of this syndrome in bronchial asthma is caused by an allergic inflammation of the mucous membranes of the respiratory tract with the participation of leukotrienes. It is found that the blocking of leukotriene receptors using the montelukast drugs has a therapeutic effect, including in children at the age of 2 and above. The drugs are well tolerated by children, can prevent a post-exertional bronchospasm and in some clinical situations can be used as an alternative to glucocorticoids.
About the Authors
O. I. Simonova
Scientific Centre of Children’s Health, Moscow, Russian Federation
I.M. Sechenov First Moscow State Medical University, Russian Federation
Russian Federation
Russian Federation
Yu. V. Gorinova
Scientific Centre of Children’s Health, Moscow, Russian Federation
Russian Federation
Russian Federation
A. A. Alekseeva
Scientific Centre of Children’s Health, Moscow, Russian Federation
I.M. Sechenov First Moscow State Medical University, Russian Federation
Russian Federation
Russian Federation
A. A. Tomilova
Scientific Centre of Children’s Health, Moscow, Russian Federation
I.M. Sechenov First Moscow State Medical University, Russian Federation
Russian Federation
Russian Federation
References
1. Illi S., E. von Mutius, Lau S., Niggemann B., Grüber C., Wahn U. Multicentre Allergy Study (MAS) group. Perennial allergen sensitisation early in life and chronic asthma in children: a birth cohort study. Lancet. 2006; 368: 763–770.
2. Zaitseva O.V. Bronchial obstruction in children. Pediatriya = Pediatrics. 2005; 4: 94–14.
3. Martinez F.D., Wright A.L., Taussig L.M., Holberg C.J., Halonen M., Morgan W.J. Asthma and wheezing in the first six years of life. The Group Health Medical Associates. N. Engl. J. Med. 1995; 332: 133–138.
4. Rakes G.P., Arruda E., Ingram J.M., Hoover G.E., Zambrano J.C., Hayden F.G., Platts-Mills Thomas A.E., Heymann P.W. Rhinovirus and respiratory syncytial virus in wheezing children requiring emergency care. IgE and eosinophil analyses. Am. J. Respir. Crit. Care Med. 1999; 159 (3): 785–790.
5. Mathews B., Shah S., Cleveland RH, Lee E.Y., Bachur R.G., Neuman M.I. Clinical Predictors of Pneumonia Among Children With Wheezing. Pediatrics. 2009; 124: 29–36.
6. Simonova O.I. Mucolytics in pediatric patients: a rational choice, therapeutic effects and especially therapy. Voprosy sovremennoi pediatrii = Current pediatrics. 2013; 12 (4): 24–29.
7. Simonova O.I., Gorinova Yu.V. Non-mucolytic features of well-known mucolytic agent. Voprosy prakticheskoi pediatrii = Problems of practical pediatrics. 2014; 9 (5): 52–57.
8. Simonova O.I., Gorinova Yu.V., Bakradze M.D. The effectiveness of inhaled hypertonic saline children with bronchitis and bronchiolitis. Voprosy sovremennoi pediatrii = Current pediatrics. 2014; 13 (4): 12–18.
9. Tatochenko V.K. Pediatru na kazhdyi den'. Izd. 7-e, dop. [Casual Recommendations for Pediatrician. 7th edition, enlarged]. Moscow, Borges, 2012. 274 p.
10. Kulichenko T.V. Montelukast in the treatment of allergic diseases. Pediatricheskaya farmakologiya = Pediatric pharmacology. 2006; 3 (4): 32–41.
11. Report of the Working Group GINA — The Global Initiative for Asthma. Revision 2011. Available at: http://www.ginasthma.org/local/uploads/files/GINA_Russian_2011_1_1.pdf (accessed April 10, 2015).
12. Vishneva E.A., Namazova-Baranova L.S., Alekseeva A.A., Levina Yu.G., Efendieva K.E., Voznesenskaya N.I. Bronchial asthma in children. Achieving control and prevent exacerbations. Farmateka = Pharmateca. 2014; 1: 33–39.
13. Goryachkina L.A., Nasunova A.Yu. Role of antileukotriene drugs in the treatment of asthma. Consilium Medicum = Consilium Medicum. 2014; 16 (3): 14–17.
14. Baranova I.A. Antileukotriene drugs in the treatment of bronchial asthma. Consilium Medicum = Consilium Medicum 2014; 16 (11): 14–18.
15. Belyaeva L.M., Mikul'chik N.V., Voitova E.V., Panulina N.I. Antileukotriene drugs in the treatment of children with asthma. Meditsinskie novosti = Medical news. 2013; 5: 28–34.
16. Bisgaard H., Flores-Nunez A, Goh A, Azimi P, Halkas A, Malice MP. et al. Study of montelukast for the treatment of respiratory symptoms of post-respiratory syncytial virus bronchiolitis in children. Am. J. Respir. Crit. Care Med. 2008; 178 (8): 854–860.
17. Nipun S., Hongzhu L. Management of asthma with montelukast. IJSIT. 2015; 4 (1): 024–034.
18. Knyazheskaya N.P. Leukotriene receptor antagonists - anti-inflammatory drugs for the treatment of bronchial asthma. Astma i allergiya = Asthma and allergy. 2014; 1: 8–10.
19. Global'naya strategiya lecheniya i profilaktiki bronkhial'noi astmy. Peresmotr 2006 g. Per. s angl. Pod red. A.G. Chuchalina [Global Strategy for Treatment and Prevention of Asthma. Revision of 2006. Trans. from English. Edited by A.G. Chuchalin]. Moscow, Atmosfera, 2007. 256 p.
20. Berezovskii A.S., Nezabudkin S.N., Antonova T.I., Nezabudkina A.S. Leukotriene receptor antagonist (montelukast) in the treatment of persistent asthma lung flow. Russkii meditsinskii zhurnal = Russian medical journal. 2010; 924: 1450–1452.
21. Vasilevskii I.V., Skep'yan E.N. Experience of montelukast in the treatment of bronchial asthma in children. Pediatricheskaya farmakologiya = Pediatric pharmacology. 2007; 2 (4): 15–21.
22. Baranova I.A. Modern possibilities of application antileukotriene receptors in the treatment of asthma in adults. Pul'monologiya = Pulmonology. 2014; 1: 91–96.
Review
For citations:
Simonova O.I., Gorinova Yu.V., Alekseeva A.A., Tomilova A.A. BRONCHIAL OBSTRUCTION IN CHILDREN: A NEW SOLUTION TO AN OLD PROBLEM. Current Pediatrics. 2015;14(2):276-280. (In Russ.) https://doi.org/10.15690/vsp.v14i2.1298
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