Preview

Вопросы современной педиатрии

Расширенный поиск

ПОДХОДЫ К ТЕРАПИИ ОСТРЫХ РЕСПИРАТОРНЫХ ИНФЕКЦИЙ И ГРИППА ПРИ СЕЗОННОМ УВЕЛИЧЕНИИ ЗАБОЛЕВАЕМОСТИ

https://doi.org/10.15690/vsp.v14i1.1264

Полный текст:

Аннотация

Профилактика и лечение острых респираторных инфекций и гриппа у детей остаются одними из важнейших задач практического здравоохранения. Их значимость возрастает с началом осенне-зимнего сезона. В настоящее время проблема выбора эффективных и одновременно безопасных лекарственных средств при острых респираторных инфекциях у детей является весьма актуальной. В статье обсуждаются вопросы применения различных этиотропных и симптоматических лекарственных средств при острых респираторных инфекциях и гриппе у детей.

Об авторах

Л. Н. Нисевич
Научный центр здоровья детей, Москва, Российская Федерация
Россия
доктор медицинских наук, профессор, главный научный сотрудник лаборатории экспериментальной иммунологии и вирусологии НЦЗД


К. С. Волков
Научный центр здоровья детей, Москва, Российская Федерация
Россия


А. А. Алексеева
Научный центр здоровья детей, Москва, Российская Федерация Первый Московский государственный медицинский университет им. И.М. Сеченова, Российская Федерация
Россия


А. Ю. Томилова
Научный центр здоровья детей, Москва, Российская Федерация Первый Московский государственный медицинский университет им. И.М. Сеченова, Российская Федерация
Россия


В. А. Баранник
Научный центр здоровья детей, Москва, Российская Федерация
Россия


К. Е. Эфендиева
Научный центр здоровья детей, Москва, Российская Федерация Первый Московский государственный медицинский университет им. И.М. Сеченова, Российская Федерация
Россия
 

 



Список литературы

1. Ostrye respiratornye zabolevaniya u detey: lechenie i profilaktika. Nauchno-prakticheskaya programma Soyuza pediatrov Rossii [Acute Respiratory Infections in Children: Treatment and Prevention. Scientific and Practical Program of the Union of Pediatricians of Russia]. Мoscow, Mezhdunarodnyy Fond okhrany zdorov'ya materi i rebenka. 2002. 69 p.

2. Uchaykin V.F. Diagnostika, lechenie i profilaktika grippa i ostrykh respiratornykh zabolevaniy u detey. Posobie dlya vrachey [Diagnosis, Treatment and Prevention of Influenza and Acute Respiratory Infections in Children. Manual for Doctors]. Мoscow, 2001. 16 p.

3. Gendon Yu.Z. Etiologiya ostrykh respiratornykh zabolevaniy [Etiology of Acute Respiratory Infections]. Vaktsinatsiya = Vaccination. 2001; 17 (5): 12–14.

4. Meditsinskaya virusologiya [Medical Virology]. Ed. by L’vov D.K. Мoscow, MIA. 2008. 655 p.

5. Uchaykin V.F., Nisevich N.I., Shamsheva O.V. Infektsionnye bolezni u detey [Infectious Diseases in Children]. Мoscow, GEOTAR-Media, 2013. 688 p.

6. Kozulina I.S. Bokavirus v etiologii zabolevaniy u detey rannego i doshkol'nogo vozrasta [Bocavirus in the Etiology of Diseases in Young and Preschool Children]. Detskie infektsii = Child Infections. 2009; 8 (3): 13–16.

7. Osidak L.V., Muradyan A.Ya., Rumel' N.B., Drinevskiy V.P. Koronavirusnaya infektsiya.etiologiya, epidemiologiya, kliniko-laboratornaya diagnostika, protivovirusnaya terapiya. Posobie dolya vrachey [Coronavirus Infection: Etiology, Epidemiology, Clinical and Laboratory Diagnosis, Antiviral Therapy. Manual for Doctors]. SPb.: Chelovek. 2007. 53 p.

8. Ostrye respiratorye infektsii u detey i podrostkov: prakticheskoe rukovodstvo [Acute Respiratory Infections in Children and Adolescents: Practical Guide]. 2nd ed. Rev. Ed. by Osidak L.V. SPb. 2010. 213 p.

9. Korovina N.A., Zaplatnikov A.L. Ostrye respiratornye virusnye infektsii v ambulatornoy praktike vracha-pediatra [Acute Respiratory Viral Infections in the Pediatrician’s Outpatient Practice]. Мoscow, 2008. 58 p.

10. Tatochenko V.K., Rachinskiy S.V., Sporov O.A. Ostrye zabolevaniya organov dykhaniya u detey [Acute Respiratory Diseases in Children]. Мoscow, Meditsina,1981. 220 p.

11. Savenkova M.S. Lechenie virusnykh infektsiy: problema vybora effektivnykh protivovirusnykh preparatov [Treatment of Viral Infections: Problem of Choice of Effective Antiviral Drugs]. Pediatriya = Pediatrics. Consilium medicum. 2012; 16(6): 70–77.

12. Nisevich L.L., Namazova L.S., Volkov K.S., Vazhnova M.M., Botvin'yeva V.V., Zubkova I.V., Filyanskaya Ye.G. Vsegda li neobkhodimy antibiotiki dlya lecheniya zatyazhnogo kashlya u detey? [Is it Always Necessary to Use Antibiotics to Treat a Prolonged Cough in Children?] Pediatricheskaya farmakologiya = Pediatric pharmacology. 2008; 5 (3): 64–71.

13. Tatochenko V.K. Antibiotiko- i khimioterapiya infektsiy u detey [Antibiotic Therapy and Chemotherapy of Child Infections]. Мoscow, KONTINENT-PRESS, 2008. 256 p.

14. Bulgakova V.A. Ostrye respiratornye infektsii u detey: ratsional'nyy vybor farmakoterapii [Acute Respiratory Infections in Children: Rational Choice of Pharmacotherapy]. Poliklinika = Polyclinic. 2012; 1: 46–53.

15. Prakticheskoe rukovodstvo po antiinfektsionnoy khimioterapii [Practical Guide to Anti-Infective Chemotherapy]. Ed. by Strachunsky L.S., Belousov Yu.B., Kozlov S.N. Мoscow, 2002. 381 p.

16. Zhitnikova L.M. Etiotropnaya protivovirusnaya terapiya — obyazatel'nyy komponent lecheniya grippa i ORVI [Causal Antiviral Therapy – Mandatory Component of the Treatment of Influenza and ARVI]. Vestnik semeynoy meditsiny. Otorinolaringologiya = Journal of Family Medicine. Otorhinolaryngology. 2012; 1: 28–39.

17. WHO guidelines for pharmacological management of pandemic influenza A (H1N1) 2009 and other influenza viruses. Revised February 2010. Geneva: WHO. 2010.

18. Centers for Disease Control and Prevention. Morbidity and Mortality Weekly Report (MMWR). Antiviral Agents for the Treatment and Chemoprophylaxis of Influenza. Recommendations of the Advisory Committee on Immunization Practices (ACIP). Recommendations and Reports. 2011; 60 (RR01): 1–24.

19. Thorlund K., Awad T., Boivin G., Thabane L. Systematic review of influenza resistance to the neuraminidase inhibitors. BMC Inf. Dis. 2011; 11: 134.

20. Pizzorno A., Abed Y., Bouhy X., Beaulieu E., Mallett C., Russell R. Impact of mutations at residue I223 of the neuraminidase protein on the resistance profile, replication level and virulence of the 2009 pandemic influenza virus. Antimicrob. Agents Chemother. 2011; 56 (3): 1208–1214.

21. Maleev V.V., Sel'kova Ye.P., Prostyakov I.V., Osipova Ye.A. Farmakoepidemiologicheskoe issledovanie techeniya grippa i drugikh ORVI v sezone 2010/2011 g.g. [Pharmacoepidemiological Study of the Course of Influenza and Other ARVIs in the Season 2010/2011] Infektsionnye bolezni = Infectious diseases. 2012; 10 (3): 1–9.

22. Zaplatnikov A.L., Burtseva Ye.I., Girina A.A., Koroid N.V., Garina Ye.A. Sovremennye vozmozhnosti i printsipy ratsional'noy terapii grippa i drugikh ostrykh respiratornykh virusnykh infektsiy u detey [Modern Features and Principles of Rational Therapy of Influenza and Other Acute Respiratory Viral Infections in Children]. Voprosi sovremennoi pediatrii = Current Pediatrics. 2014; 13 (1): 129–133.

23. Petrov V.I., Belan V.B. Protivovirusnye sredstva [Antiviral Agents]. Мoscow, GEOTAR-Media, 2012. 244 p.

24. Arbidol: effektivnost' v terapii grippa i drugikh ORVI. Metodicheskoe posobie [Arbidol: Efficacy in the Treatment of Influenza and other ARVIs. Guidance Manual]. Ed. by Lenyova I.A. Мoscow, 2014. 84 p.

25. Leneva I.A., Fedyakina I.T., Eropkin M.Yu., Gudova N.V., Romanovskaya A.A., Danilenko D.M., Vinogradova S.M., Lepeshkin A.Yu., Shestopalov A.M. Izuchenie protivovirusnoy aktivnosti otechestvennykh protivogrippoznykh khimiopreparatov v kul'ture kletok i na modeli zhivotnykh [Study of the Antiviral Activity of Domestic Influenza Chemotherapy Drugs in the Cell Culture and in Animal Models]. Voprosy virusologii = Problems of Virology. 2010; 3: 19–27.

26. Deng H.Y., Luo F., Shi L.Q., Zhong Q., Liu Y.J., Yang Z.Q. Efficacy of arbidol on lethal hantaan virus infections in suckling mice and in vitro. Acta Pharmacol. Sin. 2009; 30 (7): 1015–1024.

27. Xing-Quan Z., Jun-Peng D., Bai-Qiang C. Thein-vitro effects of Arbidol hydrochloride against 2009 new influenza virus A (H1N1). Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2012; 34 (2): 126–129.

28. Leneva I.A., Russell R.J., Boriskin Y.S., Hay A.J. Characteristics of Arbidol-Resistant Mutants of Influenza Virus: Implications for the Mechanism of Anti-Influenza Action of Arbidol. Antiviral Res. 2009; 81: 132–140.

29. Villalain J. Membranotropic еffects of Arbidol, a broad anti-viral molecule, on phospholipid model membranes. J. Phys. Chem. B. 2010; 114 (25): 8544–8554.

30. Teissier E., Zandomeneghi G., Loquet A., Lavillette D. Mechanism of inhibition of enveloped virus membrane fusion by the antiviral drug Arbidol. PLoS ONE. 2011; 6 (1): 15874.

31. Shi L., Xiong H., He J., Deng H., Li Q., Zhong Q., Hou W., Cheng L., Xiao H., Yang Z. Antiviral activity of arbidol against influenza A virus, respiratory syncytial virus, rhinovirus, coxsackie virus and adenovirus in vitro and in vivo. Arch. Virol. 2007; 152: 1447.

32. Zhong Q., Yang Z., Liu Y., Deng H., Xiao H., Shi L., He J. Antiviral activity of Arbidol against Coxakie virus B5 in vitro and in vivo. Arch. Virol. 2009; 154 (4): 601–607.

33. Brooks M.J., Burtseva E.I., Ellery P.J., Marsh G.A., Lew A.M., Slepushkin A.N., Crowe S.M., Tannock G.A. Antiviral activity of arbidol, a broad-spectrum drug for use against respiratory viruses, varies according to test conditions. J. Med. Virol. 2012; 84 (1): 170–181.

34. 34. Burtseva Ye.I., Shevchenko Ye.S., Leneva I.A., Merkulova L.N., Oskerko T.A., Shlyapnikova O.V. Chuvstvitel'nost'kremantadinuiarbidolu virusov grippa, vyzvavshikh epidemicheskie pod''emy zabolevaemosti v Rossii v sezone 2004–2005 gg. [Rimantadine and Arbidol Sensitivity of Influenza Viruses that Caused an Epidemic Morbidity Rise in Russia in the Season 2004-2005] Voprosy virusologii = Problems of Virology. 2007; 2: 24–29.

35. Leneva I.A., Fedyakina I.T., Gus'kova T.A., Glushkov R.G. Chuvstvitel'nost' razlichnykh shtammov virusa grippa k arbidolu. Izuchenie effekta arbidola na reproduktsiyu virusa grippa A v kombinatsii s razlichnymi protivovirusnymi preparatami [Sensitivity of Different Influenza Virus Strains to Arbidol. Study of the Arbidol Effect on the Reproduction of the Influenza A Virus in Combination with Various Antiviral Drugs]. Terapevticheskii Arkhiv = Therapeutic Archive. 2005; 8: 84–88.

36. Fediakina I.T., Shchelkanov M.Iu., Deriabin P.G., Leneva I.A., Gudova N.V., Kondrat'eva T.V. Susceptibility of pandemic influenza virus A 2009 H1N1 and highly pathogenic avian influenza virus A H5N1 to antiinfluenza agents in cell culture. Antibiot. Khimioter. 2011; 56 (3–4): 3–9.

37. Petrov V.I., Lenyova I.A., Nedogoda S.V. Primenenie otechestvennogo protivovirusnogo preparata s pozitsii dokazatel'noi meditsiny [Use of a Domestic Antiviral Drug from the Perspective of Evidence-Based Medicine]. Lechashhij vrach = Practicing Doctor. 2011; 1: 71–79.

38. Ershov F.I. Pravda i mify ob interferonakh [Truth and Myths about Interferons]. Vestnik Ferona = Feron Journal. 2014; 2: 36–39.

39. Meshcheryakova A.K., Kostinov M.P., Kyt'ko O.V., Malinovskaya V.V., Fayzuloev Ye.B., Nikonova A.A., Tarbaeva D.A., Cherdantsev A.P. Klinicheskii effekt primeneniya preparatov Viferon u beremennykh s ostroy respiratornoy infektsiei [Clinical Effect of Viferon in Pregnant Women with Acute Respiratory Infections]. Vestnik Ferona = Feron Journal. 2014; 2: 22–27.

40. Kiselev O.I., Yershov F.I., Bykov A.T., Pokrovskiy V.I. Pandemiya grippa 2009/2010: protivovirusnaya terapiya i taktika lecheniya [Influenza Pandemic 2009/2010: Antiviral Therapy and Treatment Strategy]. SPb.: А-Print. 2010. 97 p.

41. Romantsov M.G., Goryacheva L.G., Kovalenko A.L. Protivovirusnye i immunotropnye preparaty v detskoy praktike [Antiviral and Immunotropic Drugs in Pediatric Practice]. SPb. 2009. 119 p.

42. Romantsov M.G., Yershov F.I. Chasto boleyushchie deti. Sovremennaya farmakopeya [Frequently Ill Children. Modern Pharmacopoeia]. Мoscow, GEOTAR-Media, 2009. 352 p.

43. Gus'kova T.A., Glushkov R.G. Arbidol – immunomodulyator, induktor interferona, antioksidant [Arbidol – Immune Modulator, Interferon Inducer, Antioxidant]. Мoscow, TsKhLS – VNIKhFI, 1999. 93 p.

44. Sel'kova Ye.P., Grachyova I.Yu., Gotvyanckaya T.P., Danilina G.A., Amaryan M.P., Semenenko T.A. Izuchenie immunomoduliruyushchey aktivnosti arbidola [Study of Immunomodulatory Activity of Arbidol]. RMZh = Russian Medical Journal. 2001; 9 (16/17): 728–730.

45. Sel'kova Ye.P., Semenenko T.A., Uchaykin V.F., Shuster A.M., Polezhaeva N.A. Profilakticheskaya i lechebnaya effektivnost' Arbidola [Preventive and Therapeutic Efficacy of Arbidol]. Zhurn. mikrobiol., epidemiol. i immunol = Journal of Epidemiology, Microbiology and Immunology. 2005; 4: 17–24.

46. Otchet «Provedenie eksperimental'nykh issledovaniy po kantserogennoy aktivnosti Arbidola» [Report: Experimental Studies on the Carcinogenic Activity of Arbidol]. Мoscow, MRNTs RAMN, 1992.

47. Samsygina G.A. Chasto boleyushchie deti: problemy patogeneza, diagnostiki i terapii [Frequently Ill Children: Problems of Pathogenesis, Diagnosis and Therapy]. Pediatriya im. G.N. Speranskogo = PEDIATRIYA-MOSCOW. 2005; 1: 66–74.

48. Torshkhoeva R.M., Botvin'yeva V.V., Tagizade T.G. Chasto boleyushchie deti megapolisov: lechenie i profilaktika ostrykh respiratornykh infektsiy [Frequently Ill Children in Big Cities: Treatment and Prevention of Acute Respiratory Infections]. Pediatricheskaya farmakologiya = Pediatric pharmacology. 2006; 1: 13–17.

49. Bulgakova V.A., Balabolkin I.I., Centsova T.B. Respiratornaya virusnaya infektsiya u detey i podrostkov s allergicheskoy patologiey [Respiratory Viral Infections in Children and Adolescents with Allergic Pathology]. Detskie infektsii = Child Infections. 2005; 4 (4): 17–24.

50. Zaplatnikov A.L., Korovina N.A. Chasto boleyushchie deti: sovremennoe sostoyanie problemy [Frequently Ill Children: Status Update on the Problem]. Voprosy prakticheskoi pediatrii = Problems of Practical Pediatrics. 2008; 3 (5): 103–109.

51. Yartsev M.N., Plakhtienko M.V. Chasto boleyushchie deti i immunnaya nedostatochnost' [Frequently Ill Children and Immune Deficiency]. Rossiiskii allergologicheskii zhurnal = Russian Journal of Allergy. 2010; 5: 58–66.

52. Kazyukova T.V., Koval' G.S., Samsygina G.A. Chasto boleyushchie deti: sovremennye vozmozhnosti snizheniya respiratornoy zabolevaemosti [Frequently Ill Children: Current Opportunities to Reduce Rates of Respiratory Diseases]. Pediatriya im. G.N. Speranskogo = PEDIATRIYA-MOSCOW. 2012; 91 (5): 42–48.

53. Al’bitsky V.Yu., Baranov А.А. Chasto boleyushchie deti. Kliniko-sotsial'nye aspekty [Frequently Ill Children. Clinical and Social Aspects]. Saratov, Izd-vo Saratovskogo gosudarstvennogo universiteta im. N.G. Chernyshevskogo. 1986. 184 p.

54. Savenkova M.S., Afanas'yeva A.A., Minasyan V.S., Tyurkina S.I. Lechenie chasto boleyushchikhdetey so smeshannoy infektsiey [Treatment of Frequently Ill Children with Mixed Infections]. Voprosy sovremennoi pediatrii = Current Pediatrics. 2011; 10 (4): 83–88.

55. Bulgakova V.A., Khanova N.I., Antonova Ye.V., Molochkova O.V. Lechebno-profilakticheskaya effektivnost' otechestvennogo protivovirusnogo preparata v pediatrii [Therapeutic Efficacy of a Domestic Antiviral Drug in Pediatrics]. Pediatriya im. G.N. Speranskogo = PEDIATRIYA-MOSCOW. 2013; 92(3): 78–85.

56. Bulgakova V.A. Ostrye respiratornye infektsii u chasto boleyushchikh detey: rol' etiotropnogo preparata v profilaktike i lechenii [Acute Respiratory Infections in Frequently Ill Children: Role of Etiotropic Drugs in Prevention and Treatment]. Pediatriya im. G.N. Speranskogo = PEDIATRIYA-MOSCOW. 2013; 92 (6): 87–94.

57. Cheshik S.G., Vartanyan R.V. Effektivnost' terapii Arbidolom pri ORVI u detey rannego vozrasta [Arbidol Efficacy in Treatment of ARVIs in Young Children]. Novye lekarstvennye preparaty = New Drugs. 2005; 11: 37–44.

58. Uchaykin V.F., Shuster A.M., Kladova O.V., Mednikov B.L. Arbidol v profilakike i lechenii grippa i drugikh ostrykh respiratornykh virusnykh infektsiy u detey [Arbidol in Prevention and Treatment of Influenza and Other Acute Respiratory Viral Infections in Children]. Pediatriya im. G.N. Speranskogo = PEDIATRIYA-MOSCOW.2002; 81 (6): 61–64.

59. Lenyova I.A., Gus'kova T.A. Arbidol — effektivnyy preparat dlya lecheniya i profilaktiki grippa i ORVI: obzor rezul'tatov klinicheskikh [Arbidol – Effective Drug for the Treatment and Prevention of Influenza and ARVIs: Review of Clinical Studies]. RMZH = RUSSIAN MEDICAL JOURNAL. 2008; 16 (29): 1972–1977.

60. Likhoradochnye sindromy u detey: rekomendatsii po diagnostike i lecheniyu [Febrile Syndromes in Children: Recommendations for Diagnosis and Treatment]. Endorsed by Baranov А.А., Tatochenko V.K., Bakradze M.D. Мoscow, Soyuz pediatrov Rossii, 2011. 228 p.


Для цитирования:


Нисевич Л.Н., Волков К.С., Алексеева А.А., Томилова А.Ю., Баранник В.А., Эфендиева К.Е. ПОДХОДЫ К ТЕРАПИИ ОСТРЫХ РЕСПИРАТОРНЫХ ИНФЕКЦИЙ И ГРИППА ПРИ СЕЗОННОМ УВЕЛИЧЕНИИ ЗАБОЛЕВАЕМОСТИ. Вопросы современной педиатрии. 2015;14(1):64-69. https://doi.org/10.15690/vsp.v14i1.1264

For citation:


Nisevich L.L., Volkov K.S., Alekseeva A.A., Tomilova A.Yu., Barannik V.A., Efendieva K.E. APPROACHES TO THE TREATMENT OF ACUTE RESPIRATORY INFECTIONS AND INFLUENZA DURING THE SEASONAL INCREASE IN THE INCIDENCE OF DISEASES. Current Pediatrics. 2015;14(1):64-69. (In Russ.) https://doi.org/10.15690/vsp.v14i1.1264

Просмотров: 562


Creative Commons License
Контент доступен под лицензией Creative Commons Attribution 4.0 License.


ISSN 1682-5527 (Print)
ISSN 1682-5535 (Online)