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ЭФФЕКТИВНОСТЬ ИБУПРОФЕНА В ТЕРАПИИ БОЛИ У ДЕТЕЙ: СИСТЕМАТИЧЕСКИЙ ОБЗОР РЕЗУЛЬТАТОВ РАНДОМИЗИРОВАННЫХ КОНТРОЛИРУЕМЫХ ИССЛЕДОВАНИЙ

Аннотация

Представлены результаты систематического обзора исследований, в которых изучалась профилактическая и терапевтическая эффективность ибупрофена. Поиск в базе данных PubMed и с помощью поисковой системы Google позволил обнаружить 27 публикаций по анализируемой теме. Профилактическая эффективность ибупрофена была изучена в 14 исследованиях. Обобщение их результатов показало, что ибупрофен, по сравнению с плацебо, предупреждает возникновение боли и снижает ее интенсивность в последующем — после проведения ряда хирургических вмешательств или оказания стоматологической помощи. Не обнаружено принципиальных различий в профилактической эффективности ибупрофена и ацетаминофена при однократном назначении этих препаратов. Терапевтическая эффективность ибупрофена была изучена в 13 исследованиях. Обоснованность применения препарата для купирования боли у детей не вызывает сомнений. Его анальгетический эффект подтвержден во всех исследованиях с плацебо у больных с мигренью и ЛОР-заболеваниями. В 5 исследованиях, проведенных в последние годы, доказана эффективность применения ибупрофена в травматологической практике, в том числе и у детей с неосложненными переломами конечностей.
Ключевые слова: дети, боль, ибупрофен, профилактика, лечение.
(Вопросы современной педиатрии. 2010;9(1):52-62)

Об авторе

Р.Т. Сайгитов
Научный центр здоровья детей РАМН, Москва
Россия


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Для цитирования:


Сайгитов Р. ЭФФЕКТИВНОСТЬ ИБУПРОФЕНА В ТЕРАПИИ БОЛИ У ДЕТЕЙ: СИСТЕМАТИЧЕСКИЙ ОБЗОР РЕЗУЛЬТАТОВ РАНДОМИЗИРОВАННЫХ КОНТРОЛИРУЕМЫХ ИССЛЕДОВАНИЙ. Вопросы современной педиатрии. 2010;9(6):52-62.

For citation:


Saygitov R. EFFICACY OF IBUPROFEN IN TREATMENT OF PAIN IN CHILDREN: SYSTEMATIC REVIEW OF RANDOMIZED CONTROLLED STUDIES. Current Pediatrics. 2010;9(6):52-62. (In Russ.)

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