Background. Nowadays there is no consensus on the tactics and optimal protocol for Continuous Positive Airway Pressure (СРАР) at transient tachypnea of newborns (TTN) in delivery room.

Objective. The aim of the study is to examine the efficacy and safety of standardized protocol of CPAP therapy for newborns with TTN in delivery room.

Methods. The clinical study (implementation of standardized CPAP protocol) included full-term infants (gestational age — 37–41 weeks) with diagnosed TTN and CPAP therapy during first 60 minutes of life. Similar inclusion criteria were applied for the historical control group (born within previous year for whom CPAP was implemented according to “usual” protocol). Initiation of mononasal CPAP in main group was carried out when respiratory disorders were assessed according to Downes scale ≥ 3 points with control points at 20–40–60 minutes via the same scale, in control group at ≥ 4 points — for all cases, and according to the doctor's decision at 1–3 points. Mean airway pressure was maintained at 8 and 5–10 cm H₂O, CPAP duration was 20–60 and 5–30 min, respectively. The major endpoints: the frequency of patient transfer from delivery room to intensive care unit or hospitalization to the neonatal pathology department, as well as total period of hospitalization. Moreover, frequency of invasive manipulations (intravenous catheterization, parenteral feeding), antibacterial therapy, cerebral injuries (cerebral ischemia, intracerebral hemorrhage), nasal passages injuries, pneumothorax (in the first 24 hours of life) were recorded during the entire hospitalization period.

Results. 140 newborns with TTN were included in the clinical study, 30 were excluded from the study, specifically 13 due to violation of the CPAP protocol. The historical control group included 165 newborns. This groups were comparable for most baseline (before the start of CPAP) indicators except for maternal COVID-19 frequency during pregnancy and twin newborns frequency. This groups were comparable for most baseline (before the start of CPAP) indicators except for the frequency of maternal COVID-19 cases during pregnancy and the frequency of twin newborns. Hospitalization rate in intensive care units (18.2 versus 70.3%; p < 0.001) and neonatal pathology departments (31.8 versus 80.0%; p < 0.001), as well as total period of hospitalization (3 versus 10 days; p < 0.001) were lower in the standardized CPAP therapy group. Lower frequency of invasive manipulations, antibacterial therapy, and cerebral ischemia was recorded in this group. The safety of СРАР administration in delivery room was confirmed by the absence of nasal passages injuries in both groups, as well as comparable frequency of pneumothorax.

Conclusion. The use of standardized CPAP protocol in delivery room for full-term newborns with TTN had higher rate of favorable hospitalization outcomes. Study limitations require validation of all the findings in independent studies.

The prevalence of childhood obesity in the world is significant and it is topical issue due to the high risk of chronic non-communicable diseases development. This article presents the analysis of pathogenetic role of visceral obesity, describes modern methods for measuring visceral adipose tissue, discusses major terminology on obesity. The current data on inflammation induced by excess of visceral adipose tissue and inflammasome’s role in this process are summed up. All the findings are crucial for the development of tools for prevention any obesity associated adverse effects in children.

Ear deformities occur in 5–50% of newborns [1, 2]. Usually ear deformities minimally affect hearing, however, they can lead to psychological disorders, anxiety, social isolation, and behavioral problems. Ear deformities can spontaneously self-correct without any treatment in about 30% of cases. Surgical or non-surgical correction of ears’ shape is the only alternative for the rest of the patients. Molding is an effective method for non-surgical correction of ear deformations. It is possible to achieve better treatment results if you start the procedure during the first days of life due to sufficient plasticity of ear cartilage in newborns. Otherwise, otoplasty would be necessary at the age of 3–6 years.

Various conclusive evidence on the role of vitamin D in the pathogenesis of atopic dermatitis (AD) has been obtained in recent decades. Many studies have shown that patients with AD have low concentration of 25(OH)D in blood associated with high concentration of allergen specific IgE (according to several reports). The analysis of low 25(OH)D concentration prevalence, association of vitamin D deficiency with AD severity and sensitization to allergens, and association of vitamin D disorders with risk of AD development is presented.

The article is devoted to the history of pediatrics in Transbaikal Region and Anna Nikolaevna Bek role in children healthcare development. The topicality of Anna Nikolaevna and Evgeniy Vladimirovich Bek works in studying of Urov disease is discussed. The little-known facts about the first kindergartens implementation in Chita are presented.

The article is devoted to the end of the final (according to the authors) period in the development of classic medicine in Russia, that was based on principles dating back to the Hippocratic oath. Authors have concluded that the main paradigm has been changed from humanistic to market one after discussion of all the patterns and features of Russian medicine during XIX–XX centuries on the therapeutic and pediatric clinics models.

This article presents the results of historical and medical study reflecting the state of child health care system in Chuvash Autonomous Soviet Socialist Republic during the Great Patriotic War of 1941–1945. The aim of the study is to analyze the situation regarding children’s health care during the most crucial period for our country. We have studied published and unpublished documents from the State Archive of Russian Federation, archives of Chuvash Republic, newspapers, journals, collections of scientific articles, and monographs to cover this issue. Local health authorities have significantly reorganized their work during the war years and set new tasks for protection of local and evacuated children’s health and lives. People’s Commissariat of Public Health of Chuvash Autonomous Soviet Socialist Republic has managed to prevent the reduction in the number of pediatric medical and preventive institutions, implemented their adequate staffing level, increase the efficacy of therapeutic and preventive measures, and resist infectious diseases outbreaks even under the evacuation measures, insufficient funding, and lack of qualified specialists. The child health care system created before the war in the whole USSR (Chuvashia included) and the medical and preventive work that was carried out during the war gave positive results. Child mortality decreased by 1.7 times compared to the pre-war 1940. Thus, children’s health care in Chuvashia withstood this difficult test and proved its efficacy during the Great Patriotic War.