Efficacy of Abatacept Therapy in a Patient with Juvenile Idiopathic Arthritis and Bilateral Uveitis
https://doi.org/10.15690/vsp.v15i3.1569
Abstract
The article presents clinical observation of the patient at the age of 7 years suffering from severe juvenile idiopathic arthritis with uveitis refractory to standard antirheumatic therapy. The case complexity was determined by multiple joint damages, presence of bilateral uveitis, and hyperimmunoglobulinemia at the disease onset. The successful use of abatacept is described: remission from both the articular syndrome and uveitis, a 100% improvement by ACRpedi criteria are reached. The selection of a biological preparation was determined by a polyarticular joint disease, by the presence of active recurrent uveitis, as well as by immune status compromise for TB infection. A gradual increase in abatacept efficacy and remission maintenance for a long time period are demonstrated.
About the Authors
Lelia A. Galstian
Children’s Clinical University Hospital of I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation
Russian Federation
Russian Federation
Elena S. Zholobova
Children’s Clinical University Hospital of I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation
Russian Federation
Russian Federation
Alexandra V. Starikova
Moscow Helmholtz Research Institute of Eye Diseases, Moscow, Russian Federation
Russian Federation
Russian Federation
Ekaterina V. Denisova
Moscow Helmholtz Research Institute of Eye Diseases, Moscow, Russian Federation
Russian Federation
Russian Federation
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For citations:
Galstian L.A., Zholobova E.S., Starikova A.V., Denisova E.V. Efficacy of Abatacept Therapy in a Patient with Juvenile Idiopathic Arthritis and Bilateral Uveitis. Current Pediatrics. 2016;15(3):307-310. (In Russ.) https://doi.org/10.15690/vsp.v15i3.1569
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