Vol 6, No 2 (2007)
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EDITORIAL
SOCIAL PEDIATRICS AND HEALTH CARE
13-16 659
Abstract
In recent years, both in Russia and most economically developed countries there is a growth of illegitimate births. The birth of a child prior to marriage is usually considered as a risk factor for his health. In Murmansk maternity hospitals, there was an assessment of main health indices of 3 newborns groups: born in registered marriage (114 children), in civil marriage (106 children) and born to unwed mothers (103 children). By questioning mothers, the authors have revealed certain medical and social risk factors for their health. It was established that the health of children born in civil marriage is not worse and according to some indices it is even better than the health of children born in registered marriage. According to most parameters, the health of children born to unwed mothers was certainly worse than the health of the newly born children born to mothers in registered marriage. The differences in indices were due to a larger number of medical and social risk factors, negatively affecting the health of the children born to unwed mothers. Misbegotten children cannot be considered as one group of a social risk. We should only refer children born to unwed mothers to the high risk group, while according to the level of health risk children born in civil marriage are comparable with children born to mothers in registered marriage.
Key words: misbegotten children, health of newborns, risk factors.
Key words: misbegotten children, health of newborns, risk factors.
17-21 579
Abstract
The work deals with the complex research findings of the morbidity dynamics and HIV-infection prevalence among the pregnant women and risk for its transmission from a mother to a child, as well as the estimate of their regular medical check up, antiretroviral prevention of HIV-infection perinatal transmission, health status of children born to HIV-infected mothers and newly-born children within the general population. The research showed that recent years witnessed the steady increase of HIV-infected pregnant women and children born to them. High risk for HIV-infection perinatal transmission still persists. The article describes the reasons for the low coverage of the antiretroviral prevention among the pregnant women. The author gives an estimate of the associated diseases of the HIV-infected mother and health status of the newly born child. The work shows the necessity in development and implementation of the special prevention measures within the antenatal and postnatal regular medical check up of a mother and a child.
Key words: HIV-infected pregnant women and children they give birth to, regular medical check up, health status of mothers and newly born children.
Key words: HIV-infected pregnant women and children they give birth to, regular medical check up, health status of mothers and newly born children.
24-28 1547
Abstract
Physical growth of children is one of the most important dices for the health status of the younger generation. The study of the children's physical growth and development peculiarities in the changing social and economic conditions is deferred to the key problems of the hygiene and health protection of children and adolescents. The object of the study was he children of Voronezh region. The authors estimated the ain indices of the physical growth: height and body mass. They amined over 12 000 children: 6310 boys and 6242 girls aged between 0 and 14 years, living in the urban and rural areas. Such studies never took place in Voronezh region in a capacity like this, as well as in such a variety of sample and high degree of their representativeness (р < 0,01). The acquired data on the physical growth of children in Voronezh region in the end of the 2nd millennium demonstrates a more favor able situation (towards the capital social and economic sphere) in the region, where the children population under the study resides, if compared with the beginning of the 20th century, as well as the advantage of influence on the physical growth of biological, medical and genetic factors over the social and hygienic ones (lifestyle, environment and etc.).
Key words: physical growth, children, height, body mass.
Key words: physical growth, children, height, body mass.
ORIGINAL ARTICLES
29-34 485
Abstract
The article provides information on efficiency of different protocols of therapy with cyclosporine and methotrexate for patients suffering from severe systemic juvenile rheumatoid arthritis (JRA). it shows that a therapy combining cyclosporine with dosage of 4,4 ± 0,58 mg/kg of body per day and methotrexate with dosage of 8,1 ± 1,07 mg/m2 a week is more efficient than monotherapy with each of the same medications of same dosage. Combined use of immunosuppressants induces remission of articular syndrome and constitutional manifestations, as well as provides normalization of laboratory disease activity indications in more than 50% of cases of long clasting systemic variant of JRA on the average a year after the initiation of treatment. Combining cyclosporine with methotrexat improves the curative action of each of the medications without aggravation of their toxic influence. High efficiency of combining cyclosporine with methotrexate makes enables lowering the dosage of glucocorticoids to be taken orally, as well as not prescribing prednisolone to the severe cases of systemic variant of JRA.
Key words: juvenile rheumatoid arthritis, treatment, cyclosporine, methotrexate, combined therapy, children.
Key words: juvenile rheumatoid arthritis, treatment, cyclosporine, methotrexate, combined therapy, children.
36-41 532
Abstract
The medical strategy to address the vesicoureteral reflux is a very urgent issue in the children's nephrology. Based on the examination of 44 children with the iii–iv degree vesicoureteral reflux, aided by the complex of laboratory, functional and instrumental methods, the authors have analyzed the effect of the combined plant medication (Canephron N, Bionorica AG, Germany) on the short and long term outcomes of the antireflux operations. They have established that introduction of the medication into treatment leads to the term increase of the kidney resetting and urinary syndrome related to the inflammatory process inclusive.
Key words: vesicoureteral reflux, antireflux operations, urodynamics disorders, tubular dysfunctions, combined plant medication, children.
Key words: vesicoureteral reflux, antireflux operations, urodynamics disorders, tubular dysfunctions, combined plant medication, children.
42-47 1305
Abstract
The article is devoted to the problem of differential diagnostics for infection and autoimmune nature of the allergosepsis syndrome. In the research, the authors used bramspctq semicquantic tative immunostratographic test to identify procalcitonin, a highly sensitive lab marker for the sepsis and severe bacterial infection growth. They examined 32 patients: 19 of them, suffering from allergosepsis syndrome and having no verified diagnosis, 13 of them, suffering from an inflammation of the systemic (allergoseptic) presentations of the juvenile arthritis. the positive procalcitonin test (over 2 ng/ml) disclosed allergosepsis syndrome among 5 patients and juvenile arthritis among 4 patients. It witnessed the existence of the generalized bacterial infection, as well as it was a sufficient ground for prescription of the antibacterial medications. The negative procalcitonin test (lower than 0.5 ng/ml) was performed among 10 patients, suffering from allergosepsis syndrome, and 9 patients, suffering from juvenile arthritis, witnessed autoimmune nature of the allergosepsis syndrome, as well as it was a sufficient ground for prescription or correction of the immunoreduction therapy. Application of the procalcitonin test among children, suffering from allergosepsis syndrome, allowed for the differential diagnosis between the generalized bacterial infection and active autoimmune process along with the duly prescription of antibacterial and immunoreduction therapy.
Key words: allergosepsis syndrome, sepsis, juvenile rheumatoid arthritis, procalcitonin test, children.
Key words: allergosepsis syndrome, sepsis, juvenile rheumatoid arthritis, procalcitonin test, children.
48-50 487
Abstract
In abstract the authors represent the observation after 114 patients in age from 1 till 14 years passing the treatment last 15 years. All of them were been operated in cause of an rectal abnormality and suffering by dysfunction of terminal part of intestine and unsuccessful treatment of medics of different specification. Authors developed the principles of treatment accounting peculiarity and type of dysfunction, which noticeably improve the results of treatment.
Key words: congenital abnormality of an rectal zone, motility disturbances of large intestine, children.
Key words: congenital abnormality of an rectal zone, motility disturbances of large intestine, children.
51-53 713
Abstract
The search for the new noninvasive and information methods to estimate the intensity of the inflammatory processes during the bronchial asthma is an important task for the modern medicine, pediatrics, in particular. We have examined 20 children, suffering from moderately severe bronchial asthma in remission. patients underwent the induction of the sputum by means of nail hypertonic solution, bronchoscopic examination along with the sampling of the lavage fluid and bronchial biopsy, cytometry of the induced sputum and bronchoalveolar lavage fluid, morphometric examination of the biopsy samples of bronchi walls, determination of the nitric oxide contents in the expired air. We revealed high self descriptiveness of the cytological characteristics of the induced sputum. High percentage of neutrophiles and eosinophiles in the induced sputum disclosed during remission of the bronchial asthma, as well as thickness increase of the basilemma, ratio distortion of the ciliated and cyathiform cells in the favor of the latter, especially along with the high nitric oxide contents in the expired air indicate the continuous persistence in the allergic respiratory inflammation.
Key words: induced sputum, bronchial asthma, children.
Key words: induced sputum, bronchial asthma, children.
LITERATURE REVIEW
54-56 1250
Abstract
This article includes an overview of clinical research that study the efficiency of including into children's ration sour milk proc biotic product actimel (Danone, France), created on the basis of milk fermented with Lactobacillus bulgaricus and Streptococcus thermophilus, and enriched with culture of Lactobacillus casei DNC 114001 (commercial name L. casei imunitass).
Key words: probiotic product, children, Lactobacillus casei DN 114001.
Key words: probiotic product, children, Lactobacillus casei DN 114001.
58-62 521
Abstract
Disorders of the endothelial tissue and hemorheology function build up one of the pathogenic bases to form the acute inflammatory abnormality of the respiratory tract among children. The overview highlights the information on the role and disorders of the erythrocyte clumping and plasticity, blood viscosity and function of the endothelial tissue as a response to the acute respiratory infections among children.
Key words: endothelial dysfunction, hemorheology, hemorheological deviations, acute respiratory infections, acute bronchopulmonary diseases, children.
Key words: endothelial dysfunction, hemorheology, hemorheological deviations, acute respiratory infections, acute bronchopulmonary diseases, children.
LECTURES
63-70 16573
Abstract
Overactive bladder is a specific syndrome characterized by bladder dysfunction that is clinically manifested by imperative urination (pollakiuria, urgency, urgent incontinence and nocturia). This state is very widely spread among children: every fifth child aged 4 to 7 shows typical bladder dysfunction. Quite often if urinary distresses are not studied well enough such children are falsely diagnosed with monosymptom enuresis, which, according to our information, actually happens in only 3,9% of cases. When examining children with urinary disorders it is reasonable to be geared to the protocol of European urologist association. According to this protocol, treatment should be started with antimuscarinimedications. The only antimuscarinic medication for treating children with hyperactive bladder that is legal in Russia is oxybutinin (Driptane), that is presently considered to be the «golden standard» of pharmaceutical treatment of overactive bladder for patients of any age. This statement is based on the modern idea of overactive bladder pathogenesis, that presupposes detrusorhypersensibility to acetylcholine. However, in some cases it might be reasonable to use some other medications, physiotherapy, sometimes as part of complex therapy. If individual dosage is observed, which will enable preventing or significantly lowering possible side effects, oxybutinin will be still considered «the golden standard» for treating overactive bladder for years to come in cases when detrusor hypersensibility to acetylcholine is the key component of bladder dysfunction pathogenesis.
Key words: overactive bladder, oxybutinin, urination disorder, children.
Key words: overactive bladder, oxybutinin, urination disorder, children.
71-77 1130
Abstract
The lecture shows the modern state of the pertussis issue among the children. Based on the analysis of the presented data, the authors conclude that vaccination with the full cellular vaccine is rather safe; moreover, it protects the infants from the severe forms of the disease and lethal outcomes. However, the fact that there are children with constant contraindications to immunization with the full cellular vaccine, the change of the circulating B. pertussis serotypes, morbidity of the older children due to the loss of the postcvaccinal immunity define the necessity to introduce revaccination, as well as they are indications to the wider implementation of the non-cellular pertussis vaccine.
Key words: pertussis, children, vaccination, full cellular pertussis vaccine, non-cellular pertussis vaccine.
Key words: pertussis, children, vaccination, full cellular pertussis vaccine, non-cellular pertussis vaccine.
78-81 1405
Abstract
The lecture deals with the main causes of development of hypo vitaminoses in infants and preschool children, with the emphasis made on the lack of pathognomonic signs of vitamin in sufficiency, showing the demands for the essential vitamins, and describing the natural sources of their entering the human body. The authors compare the composition of various multivitamin preparations registered in Russian the liquid dosage form convenient for use in 1ctoc7cyearcold children.
Key words: avitaminosis, hypovitaminosis, prevention, infants, children.
Key words: avitaminosis, hypovitaminosis, prevention, infants, children.
82-87 744
Abstract
Calcium takes an active part in provision and development of the motion function (tractions, transmission of the neural impulse, muscle reactions to the neural excitement, change of the hormone activity, realizing together with adenylate cyclase). But no less important is the calcium role in participation of the supporting tissue buildup, organization of the integral child's skeletal system, in which there is 99% of the body calcium. This is a sort of depot, in which the element is in the dynamic equilibrium with its level in blood. The skeletal system acts as a buffer to support the stable level of the calcium circulation in the course of the entire life cycle. The calcium deficit among children should fully be treated, frequently conducting therapy of the accompanied pathology of the gastrointestinal tract, liver and intestinal dysbiosis. We should exclude the hereditary pathology of the calcium exchange. For the usual growth of the human body and prevention of the senile osteoporosis, the necessary amount of calcium consumption should be provided from the very childhood of a person. For the prevention and treatment of the calcium deficit among children, we use specific calcium medications together with phosphorus, magnesium, microelements and vitamins tested in clinical practice and approved by the union of pediatricians of Russia.
Key words: calcium, deficit of major mineral elements, treatment, prevention, children.
Key words: calcium, deficit of major mineral elements, treatment, prevention, children.
EXCHANGE OF EXPERIENCE
88-91 821
Abstract
The authors assesed a clinical efficacy of Zirtek (cetirizin) in 27 children with atopic dermatitis and 40 children with bronchial asthma, associated with food sensitization. Positive therapeutic effect was achieved in 92,5% patients with atopic dermatitis and 87,5% children with bronchial asthma. The improvement of lung functions, decreasing bronchial hyperrecactivity in children with bronchial asthma and of itch and skin`s inflammation in patients with atopic dermatitis are achieved.
Key words: food allergy, h1 antihistamines, cetirizine.
Key words: food allergy, h1 antihistamines, cetirizine.
92-96 863
Abstract
The paper presents the results based on the experience of pant ham (hopantenic acid) application, in treatment of 21 patients aged 7–8 years, suffering from benign childhood epilepsy with centroctemporal spikes (rolandic epilepsy), accompanied with impairments of cognitive functions (CF). Utilizing the computer testing systems, basic CF parameters were analyzed before and after the course of pant ham treatment as an add on treatment to basic antiepileptic therapy. Statistically relevant positive effect of the medicine on CF parameters was demonstrated. The authors highly estimate the clinical efficacy of the medication under study. Basic pharmacological and pharmacokinetic properties of hopantenic acid are described.
Key words: children, epilepsy, benign childhood epilepsy with centro temporal spikes (rolandic epilepsy), cognitive functions, hopantenic acid.
Key words: children, epilepsy, benign childhood epilepsy with centro temporal spikes (rolandic epilepsy), cognitive functions, hopantenic acid.
T.E. Borovik,
N.N. Semenova,
E.V. Davydova,
E.S. Dublina,
E.A. Roslavtseva,
I.V. Pisareva,
V.M. Shishchenko,
S.V. Petrichuk
97-101 903
Abstract
The article deals with the data on the mechanism of the oxygen treatment impact on the human body and expediency of its usage during various diseases; here the authors also give a description of the enteral oxygen therapy method by means of the oxygen cocktail intake, which is one of the most available ways to saturate one's blood with oxygen. The authors describe the principle of the medical effect of the oxygen cocktails, application methods and evaluation of their efficiency among children, suffering from the respiratory and digestive diseases. The research findings allow one to recoommend the use of the enteral oxygen therapy in pediatrics.
Key words: children, oxygen cocktail, oxygen therapy, cytochemical indicators.
Key words: children, oxygen cocktail, oxygen therapy, cytochemical indicators.
102-106 541
Abstract
Complications from the part of the respiratory apparatus are the main reason for the lethality among patients, suffering from mucoviscidosis. The adequate mucolytic therapy is of great importance in the complex treatment of the chronic bronchopulmonary process. In 2004, in Omsk center of mucoviscidosis, the researchers started to regularly apply a new mucolytimedication dornase alfa in treatment of children (Pulmozyme, F. Hoffmann La Roche Ltd., Switzerland). The results of the two year observation showed that dornase alfa may successfully be used in complex therapy of patients, suffering from mucoviscidosis, as well as periodical and chronic colonization of the respiratory tracts by Pseudomonas aeruginosa.
Key words: mucoviscidosis, children, dornase alfa.
Key words: mucoviscidosis, children, dornase alfa.
107-109 575
Abstract
The authors studied the impact of the Imudon bacterial lysate on the status of the tonsil microbiocenosis among the children with chronic tonsillitis in remission. They revealed a certain reduction in the level of pathogenic and opportunistic pathogenic microflora carriage, as well as intensity of the tonsil colonization after 20-day sublingual application of topical bacterial lysate. The medication may be recommended for the preventive practices among the children with chronic tonsillitis to reduce the bacterial contamination of the pharyngeal tonsils.
Key words: chronic tonsillitis, children, bacterial lysates, microbiocenosis of the mouth cavity.
Key words: chronic tonsillitis, children, bacterial lysates, microbiocenosis of the mouth cavity.
110-114 730
Abstract
The authors made a comparative efficiency evaluation of the nifuroxazide (enterofuryl) and other nalidixic acid based medications in treatment of the acute enteric infections among children. The authors determined that though they had the equal clinical efficiency (comparable terms for the couping of the disease symptoms) enterofuryl based therapy was accompanied by the activity reduction of the opportunistic pathogenic microflora (in particular, proteolytic cultures) and balance normalization of the aerobic-anaerobic microorganism populations. The application of the nalidixic acid quite on the contrary intensified the metabolic disorders among some of the patients.
Key words: acute enteric infections, children, treatment, nifuroxazide, short-chain fatty acids.
Key words: acute enteric infections, children, treatment, nifuroxazide, short-chain fatty acids.
115-118 720
Abstract
Studies the efficiency of Klarotadine (loratadine) antihistamine for treating children with seasonal allergic rhinitis. demonstrates the efficiency and safety of using home generic antihistamine for treating children with seasonal allergic rhinitis.
Key words: allergic rhinitis, seasonal allergic rhinitis, loratadine, treatment, children.
Key words: allergic rhinitis, seasonal allergic rhinitis, loratadine, treatment, children.
119-122 5754
Abstract
The purpose of the work is to study the efficiency of the diet therapy against atopic dermatitis by means of the goat's milk based products among children at different age. The researchers observed 188 children aged between 3 months and 18 years, suffering from atopic dermatitis aggravated by the mycotic infection. Patients of the main group (102 children under 3) received goat's milk based products within the hypo allergic diet — «Nanny» and «Nanny — Zolotaya Kozochka» adapted milk formulas, while children over 3 received «Amal Tea» instant goat's milk. The research findings have showed that the introduction of the goat's milk based products into the food ration leads not only to the positive short term results — achievement of the clinical remission on 12th–20th day from the moment the therapy starts, but also to the positive long term effect — remission extension, reduction of the disease recurrences, reduction of the general IgE level in blood serum and offending IgE allergens to the cow milk proteins and casein. Thus, the replacement of the cow milk based products within the ration of patients for «Nanny» and «Nanny — Zolotaya Kozochka» adapted milk formulas and «Amal Tea» instant goat's milk allows for optimization of the atopic dermatitis diet therapy among children at different age.
Key words: atopic dermatitis, diet therapy, goat's milk.
Key words: atopic dermatitis, diet therapy, goat's milk.
123-127 590
Abstract
To evaluate the status of the cognitive sphere among the children with the lengthy run of the perennial allergic rhinitis and elaborate the therapeutic tactics for the correction of the revealed disc orders, the researchers have examined 108 children aged between 14 and 15 years old. The research included patients with the exacerbation of the moderately severe or severe run of the perennial allergic rhinitis and length of the disease for no less than 3 years. As the basic therapy, the researchers prescribed mometasone nasal spray to all the children (Nasonex, Scheringcplough, USA). Before, in the course of and immediately right after the treatment, all the patients underwent the evaluation of the cognitive functions with the aid of the «binatest» and «mnemotest» test computer systems. The researchers determined the oxygen concentration in blood with handy pulse oximetry OXY 9. The research findings showed that 95,3% of the examined children suffered from the disorders of the cognitive functions. The application of the adequate anti-inflammatory therapy of the perennial allergic rhinitis effectively corrected the changes in the cognitive sphere of the children, suffering from the perennial allergic rhinitis. The oxygen concentration in blood of the children with the perennial allergic rhinitis remained normal at different stages of the disease. Thus, children, persistently suffering from the perennial allergic rhinitis, are recommended to undergo monitoring of the cognitive functions and prompt prescription of the adequate anti-inflammatory therapy of the disease.
Key words: children, perennial allergic rhinitis, cognitive functions, treatment, mometasone.
Key words: children, perennial allergic rhinitis, cognitive functions, treatment, mometasone.
A DOCTOR’S AID
128-130 1170
Abstract
The article deals with urgent questions of the rational application of antifebriles among children. The author provides modern data on the efficiency and safety of antifebriles applied in pediatric practices.
Key words: fever, antifebriles, paracetamol, ibuprofen, children.
Key words: fever, antifebriles, paracetamol, ibuprofen, children.
132-134 568
Abstract
The article deals with the findings in the evaluation of the allergenic properties of «R.O.K.S.» lime toothpastes for infants under 3 and «R.O.K.S.» raspberry and strawberry toothpastes for children aged between 4 and 7 years old based on the adequate model of the animals with the contact dermatitis by means of the passive skin anaphylaxis. The authors proved that both toothpastes did not have any allergenic effect and may be recommended for application among children disposed to allergic reactions.
Key words: hypo sensible toothpastes, children.
Key words: hypo sensible toothpastes, children.
136-138 610
Abstract
The authors highlight the application experience of cetirizine (Parlazin, Egis, Hungary) among 27 children aged between 3 and 17 years, suffering from hives, allergic dermatitis (common and contact), atopic dermatitis and associated respiratory allergy presentations. They showed the clinical efficiency of a medication and its good tolerance.
Key words: cetirizine, allergic dermatitis, atopic dermatitis, children, treatment.
Key words: cetirizine, allergic dermatitis, atopic dermatitis, children, treatment.
CLINICAL OBSERVATIONS
139-142 833
Abstract
The article provides a clinical and morphologic description of a rare case of systemic sclerosis along with the beginning of the diseases during the infancy. In the clinical picture, the researchers identified occurrences of the systemic vasculitis: abundant cyanotic and red spotty rash with atrophy in the middle, thick edemas of legs and ankles, necrosis of the nail bone of the left little finger, banti's syndrome. In the histological picture, most characteristic peculiarities were: 3 stages of systemic sclerosis process development — inflammation, hardening and atrophy; disorganization of collagenous corium fibers; nidi of calcification along the borderline of corium and hypoderm; multiple ulcers of small and large intestines, perforation of one of which caused peritonitis and fatal outcome of the patient.
Key words: infants, vasculitis, systemic sclerosis.
Key words: infants, vasculitis, systemic sclerosis.
143-145 549
Abstract
The article demonstrates a case of rare hereditary syndrome observation — with the multiple hereditary exostosis (MHE) syndrome in a 7 years old girl. The article covers hereditary and clinical features and life prognosis of the syndrome.
Key words: intracranial hypertension, multiple hereditary exostosis (MHE) syndrome, craniostenosis, children.
Key words: intracranial hypertension, multiple hereditary exostosis (MHE) syndrome, craniostenosis, children.
SHORT REPORTS
146-153 490
Abstract
And:
O.N. Smirnova, S.A. Egorova Clinical manifestations of bleeding disorders in children of Stavropol Territory
.A. Gromov, E.L. Semikina, L.S. Namazova Clinical and immunological value of the expression of membrane receptors in children with atopic asthma allergen during immunotherapy
E.I. Ermolaeva The value of environmental and social factors in the development of peptic ulcer disease in adolescence
O.N. Smirnova, S.A. Egorova Clinical manifestations of bleeding disorders in children of Stavropol Territory
.A. Gromov, E.L. Semikina, L.S. Namazova Clinical and immunological value of the expression of membrane receptors in children with atopic asthma allergen during immunotherapy
E.I. Ermolaeva The value of environmental and social factors in the development of peptic ulcer disease in adolescence
INFORMATION FROM THE UNION OF PEDIATRICIANS OF RUSSIA
HISTORY OF PEDIATRICS
ISSN 1682-5527 (Print)
ISSN 1682-5535 (Online)
ISSN 1682-5535 (Online)
