Vol 6, No 4 (2007)
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SOCIAL PEDIATRICS AND HEALTH CARE
7-10 625
Abstract
There was a survey of 88 pediatricians and 164 mothers, who brought their children to the polyclinic. Most respondents prefer new types of relations between the doctor and the patient's parents. Despite that only every fifth mother chose an authoritarian model, 38,4% of all the respondents do not want to participate in decision making regarding the medical intervention. A few doctors give parents information on the methods used to examine children, probable complications of a disease and side effects of the medical intervention. 62,5% of the pediatricians always receive the informed voluntary consent to the medical intervention from the parents, while 27,3% of the pediatricians always receive the informed voluntary consent to the medical intervention from a child. The doctors are quite often unacquainted with the regulations, sanctioning the disclosure of the medical secrecy. Only 59% of them support the right of parents to deny the medical intervention. Most pediatricians of the outpatient network admitted the level of their knowledge in the field of the biomedical ethics, patient's rights, social and legal protection of the medical staff and their responsibility in case of the damage caused to the patient to be insufficient.
Key words: child patient, autonomy, patient's rights, informed consent.
Key words: child patient, autonomy, patient's rights, informed consent.
12-16 868
Abstract
The article presented the results of the analysis of the environ mental situation and dynamics of the statistical morbidity and invalidity indices during the allergic pathologies among children in different Russian regions for the period between 2001 and 2005. The authors uncovered the interrelation of the spread of bronchial asthma, allergic rhinitis, atopic dermatitis and accompanied invalidity with the ecological and geographical peculiarities of different regions of the Russia federation (comfort of the climatic conditions, level of the water and air pollution). During the rehabilitation of the children, suffering from the allergic diseases, it is recommended to optimize the hygiene and sanitary indices of the environment, prolonged monitoring for the health status and their sanitation with regards to the complex impact of the manccaused pollution on the child's health.
Key words: ecology, environmental factors, allergic diseases, infant population.
Key words: ecology, environmental factors, allergic diseases, infant population.
ORIGINAL ARTICLES
17-22 609
Abstract
The article presents the evaluation results of esomeprazol efficacy in the complex therapy for gastroesophageal reflux disease among 152 children aged between 3 and 18, suffering from juvenile arthritis. The treatment scheme used in treatment induced the remission of gastro esophageal reflux disease among 45% of patients, conduced to considerable decrease of the esophagus affect intensity among 53% of patients, epithelized erosions of the mucous coat of esophagus among 30 of 32 children. The medication did not cause any clinically significant side responses among the cured children (even younger ones) and may be applied to treat gastro esophageal reflux disease among the patients, suffering from juvenile arthritis.
Key words: gastroesophageal reflux disease, children, treatment, reflux, esomeprazol, esophagitis, juvenile rheumatoid arthritis.
Key words: gastroesophageal reflux disease, children, treatment, reflux, esomeprazol, esophagitis, juvenile rheumatoid arthritis.
23-28 631
Abstract
The article highlights the issue of the effects of the nucleotides, being a part of the modern artificial mixtures, on the state of the local immunity among children. The authors present the literature data, witnessing the close interrelation between the feeding and level of secretory immunoglobulin a (SIgA) in coprofiltrates. They also present the data of their own research based on the dynamic observation of 85 clinically healthy infants aged between 1 and 4 months. The article demonstrates the clear dependence of the SIgA level upon the character of the infant feeding.
Key words: infants, feeding, nucleotides, secretory immunoglobulin A, coprofiltrates, local immunity, intestine microbiocenosis.
Key words: infants, feeding, nucleotides, secretory immunoglobulin A, coprofiltrates, local immunity, intestine microbiocenosis.
29-32 594
Abstract
The article highlights the findings of the clinical research of the Viferon ointment therapeutic efficacy, containing human recombinant C2 interferon, among children, suffering from the acute respiratory viral infections. Based on the analysis of the clinical and immunological examination findings, which included the evaluation for the stoppage of the main disease symptoms, local immunity parameters dynamics (lysozyme, a secretory immunoglobulin) and cytokine status, they proved high efficacy of the local if therapy during the acute respiratory viral infections. The researchers uncovered the preventive effects of the ointment, containing C2 interferon, in respect of the super infection by other respiratory viruses, which would allow one to optimize the antiepidemic regime in the in patient conditions.
Key words: acute respiratory viral infection, children, local if therapy, interferon 2.
Key words: acute respiratory viral infection, children, local if therapy, interferon 2.
33-37 603
Abstract
Respiratory distress syndrome is one of the main reasons of the high risk morbidity and lethality among the newborn children in early neonatal period. The aim of the present research is to study the acid resistance and electrophoretic mobility of the red cells among the term infants with severe respiratory distress syndrome. The results of the research showed that among the newborn children with severe respiratory distress sync dome (n = 41) the electrophoretic mobility of the red cells is reduced, while the acid resistance is increased, which speaks of the disorder in the functional activity of the red cells and tension of erythrogenesis in the given group of the newborn children if compared with 44 children without distress syndrome.
Key words: newborn children, respiratory distress syndrome, red cells, acid resistance of the red cells, electrophoretic mobility of the red cells.
Key words: newborn children, respiratory distress syndrome, red cells, acid resistance of the red cells, electrophoretic mobility of the red cells.
38-42 742
Abstract
Rett syndrome represents one of the most important neuropsychiatric genetic diseases. It affects generally girls with the incidence 1:10000–1:15000. Mutations in clinked gene mecp2 are considered as the main cause of the disease. The particular patterns of chromosome x replication (type C) are observed in affected females allowing the cytogenetic technique application for the diagnosis. Cytogenetic and molecular genetic studies carried out in the present work allowed us to propose an integrated approach for the diagnosis of this disease. A clinical description, cytogenetic analyses (assessment of an abnormal chromosome X replication type in affected females as well as chromosome complement abnormalities in affected males), molecular cytogenetic assays using DNA probes specific for mecp2 gene region, studying mecp2 mutations, and x chromosome inactivation pattern studies were combined in order to provide the efficient clinical and genetic diagnosis of RTT as well as counseling of family with affected children. The data obtained have shown to increase significantly the efficiency of the diagnosis as well as genetic counseling of families with Rett syndrome affected children.
Key words: Rett syndrome, x-chromosome inactivation, mecp2 mutations, replication of chromosome x, children.
Key words: Rett syndrome, x-chromosome inactivation, mecp2 mutations, replication of chromosome x, children.
LITERATURE REVIEW
44-53 3127
Abstract
Within the structure of the inflammatory diseases of the gastrointestinal tract among children, one may single out a specific group of the chronic pathology of the digestive apparatus — eosinophilic diseases of the gastrointestinal tract and gastroenterological manifestations of the food allergy. The food allergy is characterized by the pathologic immune reactivity among commonly genetically predisposed people. Depending on the peculiarities of the immune reactivity of a sick person and the nature of the allergen, the allergic reaction may evolve with primary involvement of the different mechanisms or th2 IgE-mediated, or Th1 non-igecmediated. Clinical picture of the food allergy is the manifestation of the immunoinflammatory process caused by the interaction of the food antigens with the structures of the lymphoid tissues associated with the mucous membranes of this or that target organ. The morphological basis of the clinical picture is mostly immune inflammation with primarily eosinophilic tissue infiltration. The eosinophilic lesions of the gastrointestinal tract include eosinophilic esophagitis, eosinophilic gastroenteritis, eosinophilic enteritis, eosinophilic colitis, eosinophilic proctitis and other states. During the food allergy each of the clinical forms of the gastrointestinal tract lesion has its own peculiarities with regards to the primary development mechanism, age of manifestation, character of the run and behaviour tactics.
Key words: eosinophilic inflammation, esophagitis, gastroenteritis, colitis, food allergy.
Key words: eosinophilic inflammation, esophagitis, gastroenteritis, colitis, food allergy.
54-58 579
Abstract
The lecture highlights the modern approaches to the therapy for atopic dermatitis among children and adults, as well as reviews the principles of the external therapy prescription with regards to the localization of the rush on the patient's skin. The authors presents the most important findings of pimecrolimus clinical tests, including the information on the cream efficacy and tolerance if applied to the skin on the face and other parts with thin and sensitive skin.
Key words: atopic dermatitis, children, adults, therapy, pimecrolimus.
Key words: atopic dermatitis, children, adults, therapy, pimecrolimus.
59-65 675
Abstract
The article analyzes the data on the physiological role of calcium, most significant risk factors for the phosphoccalci exchange disorders in the childhood, clinical manifestations of the calcium deficit. The authors also present the modern approaches to the prevention and correction of the micronutrient deficiency among children.
Key words: children, calcium, exchange, deficit, prevention.
Key words: children, calcium, exchange, deficit, prevention.
LECTURES
66-73 1083
Abstract
The present publication is the second in a series of the brief lectures dedicated to the characteristics of the system of the immunobiological control over the individual and continuous antigenic contents of the body, as well as immune-associated syndromes most recurrent among people: allergies, immunodeficiency states, pathological tolerance, and immune self aggression diseases. In the first lecture, the author analyzes the modern data on the structure and functions of the immunobiological supervision system. Below is the overview of etiology, pathogeny and principles of therapy for the allergic responses and states.
Key words: allergy, allergy transmitters, cytokines, membrane attack complex, hyposensitization.
Key words: allergy, allergy transmitters, cytokines, membrane attack complex, hyposensitization.
74-79 742
Abstract
The lecture is dedicated to the immune correction for tonsillitis and pharyngitis among children. The author defines the local nonspecific protection of the mucous membranes. The article also reviews the ways for correction of the immunity deficiency. It offers the selection principles for the immune corrective medication for tonsillitis and pharyngitis. The author characterizes the bacterial lysates and explains the advantages of imudon topical immunomodulator in treatment and prevention of tonsillitis and pharyngitis among children.
Key words: children, tonsillitis, pharyngitis, topical immunomodulators.
Key words: children, tonsillitis, pharyngitis, topical immunomodulators.
80-86 573
Abstract
The authors review the application peculiarities of augmentin combined antibiotic (amoxicillin + clavulanic acid), analyze its efficacy during the exacerbation of the chronic obstruction bronchopulmonary process among children. They provide indications, contraindications and intake peculiarities of the given medication among children.
Key words: amoxicillin, clavulanic acid, chronic obstruction lung diseases, exacerbation, children.
Key words: amoxicillin, clavulanic acid, chronic obstruction lung diseases, exacerbation, children.
88-90 522
Abstract
The article characterizes the modern approach to the lacto containing probiotics application in the clinical practices. The authors clarify the mechanisms of the functional activity of the lacto bacteria, l. reuteri inclusive. It is recommended to use the lacto containing probiotics in the complex therapy for acute enteric infections, gastroenterological and allergic diseases, functional disorders of the gastrointestinal tract, secondary immunodeficiency states.
Key words: probiotics, lacto bacteria, children, infectious and noninfectious diseases of the gastrointestinal tract, nutrition, immunity.
Key words: probiotics, lacto bacteria, children, infectious and noninfectious diseases of the gastrointestinal tract, nutrition, immunity.
91-100 496
Abstract
The lecture give substantiation for the choice of the quality characteristics of the milk formula contents for feeding term infants for the period of the neonatal adaptation to the conditions of the extrauterine life. The physiological premise for choosing the formula is based on the colostrum contents, which is «the gold standard» for newborn feeding. The authors provide the comparative characteristics and match the contents of the mature milk, colostrum and a number of the start milk formulas.
Key words: newborn child, feeding, colostrum, breast milk, milk formula, start formula, prebiotics, probiotics, micro-biocenosis.
Key words: newborn child, feeding, colostrum, breast milk, milk formula, start formula, prebiotics, probiotics, micro-biocenosis.
102-105 576
Abstract
The present overview is dedicated to the issue of the unpleasant emotions among the patients of the pediatric in patient departments. Among the children, the admission to the in patient department is accompanied with the relative effects predominance of the adrenal link of the sympathoadrenal system, which may lead to their depletion against the background of the rapid decrease of their reserves if accompanied with the excessive emotional and psychic or attached painful loads. The authors give recommendations as to the use of the benzodiazepines among children, who are frightened about the treatment and diagnostic manipulations to come.
Key words: children, stress, sedation, benzodiazepines.
Key words: children, stress, sedation, benzodiazepines.
EXCHANGE OF EXPERIENCE
106-112 606
Abstract
The article presents the findings of the research dedicated to the efficacy, bioavailability and safety of the generic medications and authentic cyclosporine a. it shows that the application of the generic medications leads both to the reduction in the treatment efficacy and development of the severe side effects. It also presents the information on the qualitative and quantitative contents of cyclosporine a generic medications. Neither of the tested medications complied with authentic Sandimmune Neoral in terms of qualitative and quantitative contents. Likewise, neither of the generic medications has the microemulsive form, which provides for the uniform absorption of a medication and its bioavailability. There are also clinical examples of the application experience, regarding cyclosporine a generic medications among the patients with severe systemic rheumatoid arthritis. The application of the generic medications proved to be ineffective and was accompanied by the growth of renal toxicity.
Key words: cyclosporine generics, children, juvenile rheumatoid arthritis.
Key words: cyclosporine generics, children, juvenile rheumatoid arthritis.
113-117 567
Abstract
The nutrient support of the children after cardiosurgical interventions is currently reviewed as the most important factor in the complex of therapy, which is capable to prevent the catabolic trend of metabolism and risk for the development of the postsurgical complications. In this respect, in the cardiosurgery, high requirements for the nutritious mixtures are set during the enteral feeding. Such requirements are met by the specialized mixtures on the basis of the serum protein hydrolysates. The authors believe that the mixture of the choice may be Nestle's semi celemental mixture alfare.
Key words: cardiosurgery, congenital heart disease, infants, enteral feeding.
Key words: cardiosurgery, congenital heart disease, infants, enteral feeding.
118-122 884
Abstract
Among the sickly children, pharyngitis and tonsillopharyngitis are quite often accompanied by pain and scratch in a throat, which is anguished for a child themselves and causes parents to worry. In the therapy for the indicated pathology, a certain place is held by a local antibiotic fusafungine. In the article, the author studies the effects of fusafungine on tonsillitis/tonsillopharyngitis and pharyngitis, running with pain in a throat, among the sickly children aged between 3 and 15. The research was carried on in 42 centers of different Russian regions and became a part of the multicentered research according to «Chibis» program. 2,609 children were examined, 1,907 of who Received fusafungine and 702 children did not. Among 78,1% of the children, the authors noted the phenomena of pharyngitis, rhinopharyngitis and acute tonsillopharyngitis. As the research showed the symptoms of rhinopharyngitis and tonsillopharync gitis were reliably arrested much faster, when applying fusafungine, thus, the clinical effects mostly emerged after 4th–5th day of the therapy. The acquired data allowed one to recommend the inclusion of fusafungine into the therapy for acute rhinopharyngitis, pharyngitis and tonsillopharyngitis among the sickly children.
Key words: rhinopharyngitis, pharyngitis, tonsillopharyngitis, fusafungine, children, treatment.
Key words: rhinopharyngitis, pharyngitis, tonsillopharyngitis, fusafungine, children, treatment.
123-127 598
Abstract
Atopic dermatitis is a wide spread disease in the practices of the pediatrician. Quite often, the development of atopic dermatitis among children is accompanied by dysbacteriosis of the intestines, whose correction assisted by the probiotics is not always efficient. The purpose of the present research was to study the «Primadophilus for children» dietary supplement efficacy and safety to restore microbiocenosis of the intestines among children with atopic dermatitis. 102 patients aged between 6 months and 6 years took a part in the open research. It was discovered that most children, who received the dietary supplement along with the basic therapy, showed restoration of the normal intestinal microflora. The positive dynamics of the skin process evaluated according to SCORAD scale was marked among 76% of children from the main group and among 68% of children from the screening group. The most drastic reduction of the SCORAD index (by 16–20 points) was noted among 52% of children from the main group and only among 30% of children from the screening group (p < 0,05). No side effects were reported during the treatment. Thus, the researchers proved that «Primadophilus for children» was an efficient and safe means for the complex therapy for atopic dermatitis among children.
Key words: microbiocenosis of the intestines, probiotics, atopic dermatitis, children.
Key words: microbiocenosis of the intestines, probiotics, atopic dermatitis, children.
128-131 569
Abstract
The article reviews the positive application experience of bronchipret phytomedication as a monotherapy for the cough syndrome among preschool children and infants with acute respiratory diseases.
Key words: preschool children, cough, acute respiratory diseases, phytomedications.
Key words: preschool children, cough, acute respiratory diseases, phytomedications.
132-136 847
Abstract
The authors carried on the study with regards to the feeding, which the preschool children received in the 1141st preschool educational institution. The study of 123 children aged 6 provided the findings in the areas of the physical growth and capacity for work. The average and upper average levels of the physical capacity for work were disclosed among 60–74% of the examined children irrespective of the biomaturity rates and among 86% of children with harmonious and even among 67% of children with disharmonious morpho-functional status.
Key words: feeding, physical growth, physical capacity for work, preschool children.
Key words: feeding, physical growth, physical capacity for work, preschool children.
TIPS FOR PEDIATRICIANS
137-141 1656
Abstract
The researchers analyzed the efficacy of the new medical technology aimed at rehabilitation of the preschool children with the respiratory pathology. 177 children aged between 2 and 7 with recurrent respiratory diseases, bronchial asthma or chronic pathology of the end organs have been examined for 9 months. It was uncovered that among children (n = 90), who performed the sets of the therapeutic physical training and respiratory gymnastics according to the methods developed by the authors, the recurrence of the acute respiratory diseases and exacerbations of bronchial asthma was lower by 1,83 and 1,86 timers respectively. Besides, among children of this group the researchers noted the significant improvement of the physical qualities, spirometric indices and cytological picture of the substance removed from the nasal cavity if compared with the children from the screening group (n = 87), who performed the sets of the conventional gymnastics at the physical training lessons. Thus, the researchers proved the high efficacy of the proposed technology for the rehabilitation of the children, suffering from the chronic respiratory pathology.
Key words: acute respiratory diseases, asthma, therapeutic physical training, respiratory gymnastics, children.
Key words: acute respiratory diseases, asthma, therapeutic physical training, respiratory gymnastics, children.
SHORT REPORTS
ISSN 1682-5527 (Print)
ISSN 1682-5535 (Online)
ISSN 1682-5535 (Online)
