A complex clinical social study of health status, life style and conditions of infants aged 3 months to 1 year in migrant families living in Pushkino district of Moscow region for more than 2 years was carried out. The study has revealed that children in migrant families fall behind in physical development, most of them show a delay of psychomotor development, the level of revealed pathology is significantly higher vs. children of famia lies permanently residing in the area. The data acquired indicate the need of intent attention to the children in migrant families from both medical and social authorities.

Key words: children, health status, physical development, children's condition.

A special medical and social survey was conducted to compare the quality of medical aid for teenagers at children's hospitals. The survey findings indicate that treatment of teenagers at adult inapatient hospitals and children's hospitals has both advantages and disadvantages. Thus, teenagers' treatment at children's hospitals provides for a better consistency with the primary stage of the health care system — such hospitals offer better conditions and wider possibilities for consulting. The adult inapatient departments the laboratory and instrumental examinations as well as consulting of experts are of lower quality, preahospital stage studies are often duplicated. Therefore, basing upon the findings the article recommends the health care authorities target at local conditions and opportunities in arranging inapatient aid for teenagers giving preference to treatment at children's inapatient hospitals and departments.

Key words: in patient aid, teenagers.

The study included 600 children and adolescents with epilepsy who live in the city of Tiumen and in the southern part of Tiumen region. The clinical and statistical data along with the results of EEG and neurivisualization methods were used to estimate the attributes of epilepsy in children from the city of Tiumen and the southern part of Tyumen region — the clinical course, neuroa physiologic signs and symptoms and unfavorable predictors. The obtained data provided basis for the carried out assessment of efficacy of different treatment methods.

Key words: epilepsy, EEG, adolescents, attributes.

The article demonstrated the data on changes of hemostasiologic and biochemical parameters measured in blood obtained from children with ventilationa associated pneumonia, from children with respiratory distress syndrome and from ventilated controls without pneumonia signs and symptoms. According to the results assessment, the changes of all measured lung biochemical and hemostasisaregulating parameters were severe in children who developed ventilationa associated pneumonia, and were changed to a lesser and minimal degrees in patients with RDS and controls, respectively. The mentioned changes were most evident in venous blood, clarifying the negative artertiovenous differences of the studied parameters in patients with pneumonia. The degree of arteriovenous differences of the studied parameters correlated with severity of ventilationa associated pneumonia and with the degree of pulmonary gas exchange impairment, thus allowing to consider these changes as early diagnostic criterion for ventilationa associated pneumonia in children.

Key words: ventilation associated pneumonia, RDS, children, arteriovenous gradient, lung osmotic function, lung haemostatic function.

Among serious diseases of the lower respiratory tract a special place is taken by pneumonias and chronic infectious respiratory diseases caused by pneumococcus and Haemophilus influenzae type b (HIB). The research purpose is to determine the effectiveness of vaccine combined application to treat sickly children, who often suffer from persistent infectious pathology of the respiratory tract, for flu, pneumococcal and HIB disease. 110 children aged between 3 and 12 have been vaccinated. The first part of research implied children vaccination by means of Actahib and Pneumo 23 vaccines (Sanofi Pasteur, France), the second one consisted in immunization of children with the same pathology by means of Pneumo 23, Actahib and Vaxigrip vaccines (Sanofi Pasteur, France). The researches established that within a year after HIB and Pneumo 23 vaccination the frequency of upper and lower respiratory tract acerbations reduced by 2,3 times on average; likewise, the number of system antimicrobial dosage reduced by 7,4 times along with the total duration of dosage; the carrier state of S. pneumoniae reduced by 3,7 times, H. influenzae — by 3,9 times. In the course of application of three vaccines, the frequency of persistent heat erospecific infectious bronchopulmonary pathology acerbations reduced by 3,3 times. The carrier state of S. pneumoniae reduced by 2,5 times, H. influenzae — by 4,1 times. Thus, vaccine immunization to treat for flu, pneumococcal and HIB disease in various combinations may be recoma mended for wider application to reduce the frequency and severity of heat erospecific infectious respiratory diseases among sickly children, who often suffer from various illnesses.

Key words: children with recurrent diseases, vaccination, prevention, flu, H. Influenzae, S. pneumoniae.

The purpose of this prospective multicenter surveillance study is evaluation of safety and reactogenicity of DTP vaccines, registered in Russia. 1424 children aged 12–20 weeks were enrolled in this study, 822 infants were vaccinated by AKDS, 411 — infanrix, 191 — tetracoc. The frequency and severity of 3 local (pain, redness and swelling) and 4 general (fever, irritability, drowsiness and loss of appetite) solicited symptoms were registered within 4 days after vaccination. The unsolicited adverse events were estimated within 30 days after vaccination, serious adverse events — during study period. The frequency of solicited adverse events was significantly low after infanrix administration than after DTPW vaccines. Infanrix also associated with less number of severe local and general reactions. Some difference in the reactogenicity profiles of AKDS and tetracoc vaccines was established. The conclusion about necessity of expanded using of DTPA in routine immunization programs was made.

Key words: vaccines, reactogenicity, adverse events, surveillance study.

Prevalence of upper gastrointestinal tract pathology and estimations of clinical and pharmacoeconomic efficacy of different algorithms of therapy for H. pyloria assosiated diseases in children dwelling in Krasnodar region are presented in this article.

Key words: h. Pylori, prevalence, treatment, eradication therapy, children.

Basing upon the study of conjunctive tissue frame and unstriped muscles of colon from autopsy material, as well as analysis of over 2000 clinical observations the authors set forth a new concept of etiopathogenesis of infant's chronic constipations by interpreting the functional disorders as a consequence of genetically determined status of conjunctive tissue frame. principles of conservative therapy and indications to surgery correction are considered.

Key words: chronic constipation, etiology and pathogenesis, treatment, lactulose, surgical intervention, children.

The growth rate of inflammatory bowel diseases among children actualizes early detection of this pathology form and its aftera effects, including secondary osteoporosis. The research purpose is to study the characteristics of osseous tissue mineralization, disorder of physical growth and sexual maturity of children, suffering from inflammatory bowel diseases. The researchers have examined 116 children, including 33 children, suffering from inflammatory bowel diseases; 26 children, suffering from persistent colitis; 29 children, suffering from gasatroduodenitis; and 28 children with no GI tract pathologies. The study deals with estimate of level of mineral osseous tissue density, biochemical rates of osseous metabolism, as well as physical growth and sexual maturity. reduction of mineral osseous tissue density was found among 48,5% of children, suffering from inflammatory bowel diseases, 23% of children, suffering from persistent colitis, 31% of children, suffering from chronic gastritis and 18% of almost healthy children, at the same time, it was more apparent among children, suffering from inflammatory bowel diseases. The lowest rates of mineral osseous tissue density were among girls. Calcium phosphoric metabolism did not change apart from calcium creatinine coefficient, if osteopenia was observed. Thus, reduction of mineral osseous tissue density is often observed among children, suffering from inflammatory bowel diseases, especially among adolescent girls. Therefore, it conditions the necessity to include densimetry into the conventional examination plan for children, suffering from inflammatory bowel diseases. Authors also find it advisable to monitor physical growth and sexual maturity of children.

Key words: children, inflammatory bowel diseases, osteoporosis.

The article deals with the modern view on the probiotics' role in treatment and prevention of various infant diseases. The author describes a classification of probiotics, dosage and terms of their application.

Key words: microecological internal environment, dysbacteriosis, children, probiotics, classification.

The article deals with new data about food tolerance induction among the children, belonging to the high risk groups disposed to atopy. Authors show the role of gut microflora in formation of child immune system, effect of breast feeding on activation of local immune response, growth stimulation of bifid bacteria and lactic acid bacilli. The present work gives the randomized research findings, which confirm the effectiveness of prolonged breast feeding, use of highly or partially hydrolyzed mixtures and timely introduction of supplemental feeding in food allergy prevention.

Key words: prevention, food allergy, children, breast feeding, hypo allergic mixtures, milk protein hydrolysates, supplemental feeding, gut microflora, probiotics.

In the article the characteristic of ethiology and key parts of pathogenesis of inflammation is given; modern data on the role of adhesive molecules, active forms of oxygen, lipoperoxidation processes, cytokines and other mediators in the development of acute and chronic inflammation are analyzed; the principles of its treatment are substantiated.

Key words: inflammation, phlogogenic agents, alteration, adhesion molecules.

Lactose, the constituent disaccharide of milk and other dairy products, is an important nutrient in early childhood. Lactase breaks down lactose in small intestine. In most people the activity of lactase reduces with age. In infancy lactase deficiency tends to be either transient, which is more often, or secondary to intestinal diseases. Abdominal cramps, anxiety and dyspepsia are the common symptoms of lactase deficiency. Tactics of treatment should take into account a cause and severity of the condition. A specialized milk formula «enfamil lactofree», distinguished for its' optimal formulation, high clinical effectiveness and good tolerance, could be recommended for use in children with primary, transient and secondary lactase deficiency who receive formula and mixed feeding.

Key words: lactose, lactase deficiency, lactose-free formula.

Atopic dermatitis is a chronic allergic inflammation of skin. Topical corticosteroids, calcineurin inhibitors, skin emollients, antimicrobial preparations (in complicated cases), allergen and irritant elimination are used for topical treatment of atopic dermatitis. State of the art strategy for atopic dermatitis treatment state that topical corticosteroids and calcineurin inhibitors complement each others activity in the treatment of atopic dermatitis. Pimecrolimus is indicated for early signs and symptoms, enabling to prevent atopic dermatitis flares and to control the disease course. Short aterm addition of topical corticosteroids could be used to reduce in severe flares. Pimecrolimus could be used as an alternative to topical corticosteroids when inflammation is localized on sensitive areas of skin.

Key words: atopic dermatitis, children, external therapy, pimecrolimus, topical corticosteroids.

The work studied efficacy of local intra-articular application of betametason for treating juvenile rheumatoid arthritis. The survey findings of 50 children locally treated with betametason have revealed that the medication has a distinct local anti inflammatory effect. The findings are based upon statistically reliable reduction of articular syndrome activity (number of painful and increasedasize joints, pain index and exudation) with all patients. Along with a local effect, betametason had a systematic antiainflammatory effect, which leads to reduced intensity or total disappearance of inflammation symptoms in non punctured joints as well, and to reliable reduction of ESR. Local application of betametason cut short nonasevere syndrome of glucocorticoids cessation with arthralgia, low grade fever, nausea, vomitus, muscular tremor, arterial hypotension, depression and asthenia. Local inta-articular introduction of betametason may be applied as a substitution therapy for patients with reduced or discontinued intake of peroral glucocorticoids, provided an active synovitis is present.

Key words: juvenile rheumatoid arthritis, betametason, glucocorticoids, treatment, children.

The study examined the effectiveness of sea water hypertonic solution (Aqua Maris troath and oral cavity spray, Jadran, Croatia) medication to treat chronic tonsillitis of the compensated form on 84 children aged between 5 and 15. All children had their tonsil lacunae rinsed in a day № 6–8. 64 children had them rinsed with the sea water hypertonic solution (main group), while 20 children had them rinsed with the nitrofural solution (comparison group). Treatment effectiveness was determined according to dynamics of main symptoms (odynophagia, dysphagia, hyperemia and mucosa infiltration of pillars of the fauces), as well as the degree of tonsil bacterial number before and after treatment (by the 14th day). The dynamic analysis of subjective data during treatment revealed more significant and positive changes among the children of the main group if compared with patients from the comparison group. After treatment the researchers noticed reduction of tonsil bacterial number among 90,62% of children from the main group, whereas this rate made up 60% in the comparison group. Acquired data allowed recommending this medication for the multimodality therapy of infant adenoid disease.

Key words: chronic tonsillitis, treatment, children, sea water hypertonic solution.

Nutrition therapy by «nanny» feed formula has been carried out in children with malnutrition syndrome, based on gastrointestinal allergy to cow milk protein. it were examined 88 children with middle age 4,6 month. 83 patients has shown an positive clinical changes: decrease of dyspeptic syndrome, positive changes in coproscopya, normalization of body weight, decrease of vitamin and mineral deficiency.

Key words: malnutrition, nutrition therapy, allergy.

Proper nutrition of women at pregnancy and delivery is known to provide basis for normal healthy growth and development of their children. Deficiency of animal proteins, vegetable fats, polyunsaturated fatty acids, vitamins (as b-carotine, А, Е, С, В2, В6, В12, folic acid), as well as calcium, magnesium, iron, cuprum, zinc, chrome, selenium, iodine and other microelements have been shown in the studies of actual diets of pregnant and nursing mothers in different regions of Russia, which was conducted by scientific research institute of nutrition, Russian academy of medical sciences. Methods of diet improvement to correct macro- and micronutrient deficiency in pregnant and nursing mothers, including use of specialized food products, are taken up in the article.

Key words: diet, pregnant mothers, nursing mothers, nutritive support.

The article highlights the stages of pediatric educational system formation in Russia from the 19th century till now. The author stresses the importance of pediatrician preparation at the prediploma level.

Key words: education, pediatry.